FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2073173282> ?p ?o ?g. }

• W2073173282 endingPage "e43365" @default.
• W2073173282 startingPage "e43365" @default.
• W2073173282 abstract "Background Mariner elements represent the most successful family of autonomous DNA transposons, being present in various plant and animal genomes, including humans. The introduction and co-evolution of mariners within host genomes imply a strict regulation of the transposon activity. Biochemical data accumulated during the past decade have led to a convergent picture of the transposition cycle of mariner elements, suggesting that mariner transposition does not rely on host-specific factors. This model does not account for differences of transposition efficiency in human cells between mariners. We thus wondered whether apparent similarities in transposition cycle could hide differences in the intrinsic parameters that control mariner transposition. Principal Findings We find that Mos1 transposase concentrations in excess to the Mos1 ends prevent the paired-end complex assembly. However, we observe that Mos1 transposition is not impaired by transposase high concentration, dismissing the idea that transposase over production plays an obligatory role in the down-regulation of mariner transposition. Our main finding is that the paired-end complex is formed in a cooperative way, regardless of the transposase concentration. We also show that an element framed by two identical ITRs (Inverted Terminal Repeats) is more efficient in driving transposition than an element framed by two different ITRs (i.e. the natural Mos1 copy), the latter being more sensitive to transposase concentration variations. Finally, we show that the current Mos1 ITRs correspond to the ancestral ones. Conclusions We provide new insights on intrinsic properties supporting the self-regulation of the Mos1 element. These properties (transposase specific activity, aggregation, ITR sequences, transposase concentration/transposon copy number ratio…) could have played a role in the dynamics of host-genomes invasion by Mos1, accounting (at least in part) for the current low copy number of Mos1 within host genomes." @default.
• W2073173282 created "2016-06-24" @default.
• W2073173282 creator A5010039980 @default.
• W2073173282 creator A5026338326 @default.
• W2073173282 creator A5048725361 @default.
• W2073173282 creator A5056506791 @default.
• W2073173282 creator A5069705260 @default.
• W2073173282 date "2012-08-14" @default.
• W2073173282 modified "2023-09-25" @default.
• W2073173282 title "Regulation of Mariner Transposition: The Peculiar Case of Mos1" @default.
• W2073173282 cites W1586234316 @default.
• W2073173282 cites W1864025525 @default.
• W2073173282 cites W1955053850 @default.
• W2073173282 cites W1971206410 @default.
• W2073173282 cites W1971692706 @default.
• W2073173282 cites W1978325633 @default.
• W2073173282 cites W1980223625 @default.
• W2073173282 cites W1988145049 @default.
• W2073173282 cites W1991160775 @default.
• W2073173282 cites W2004305053 @default.
• W2073173282 cites W2005623006 @default.
• W2073173282 cites W2006372594 @default.
• W2073173282 cites W2010731857 @default.
• W2073173282 cites W2011189495 @default.
• W2073173282 cites W2026830284 @default.
• W2073173282 cites W2026862785 @default.
• W2073173282 cites W2026952154 @default.
• W2073173282 cites W2031301616 @default.
• W2073173282 cites W2032391061 @default.
• W2073173282 cites W2042703141 @default.
• W2073173282 cites W2044504165 @default.
• W2073173282 cites W2044880917 @default.
• W2073173282 cites W2049385686 @default.
• W2073173282 cites W2050557699 @default.
• W2073173282 cites W2074679317 @default.
• W2073173282 cites W2087460037 @default.
• W2073173282 cites W2097178552 @default.
• W2073173282 cites W2104314729 @default.
• W2073173282 cites W2104875382 @default.
• W2073173282 cites W2117860547 @default.
• W2073173282 cites W2127660113 @default.
• W2073173282 cites W2147278677 @default.
• W2073173282 cites W2148843671 @default.
• W2073173282 cites W2152333152 @default.
• W2073173282 cites W2154021943 @default.
• W2073173282 cites W2158033500 @default.
• W2073173282 cites W2158266834 @default.
• W2073173282 cites W2270193700 @default.
• W2073173282 doi "https://doi.org/10.1371/journal.pone.0043365" @default.
• W2073173282 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3419177" @default.
• W2073173282 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22905263" @default.
• W2073173282 hasPublicationYear "2012" @default.
• W2073173282 type Work @default.
• W2073173282 sameAs 2073173282 @default.
• W2073173282 citedByCount "14" @default.
• W2073173282 countsByYear W20731732822013 @default.
• W2073173282 countsByYear W20731732822014 @default.
• W2073173282 countsByYear W20731732822015 @default.
• W2073173282 countsByYear W20731732822016 @default.
• W2073173282 countsByYear W20731732822020 @default.
• W2073173282 countsByYear W20731732822021 @default.
• W2073173282 crossrefType "journal-article" @default.
• W2073173282 hasAuthorship W2073173282A5010039980 @default.
• W2073173282 hasAuthorship W2073173282A5026338326 @default.
• W2073173282 hasAuthorship W2073173282A5048725361 @default.
• W2073173282 hasAuthorship W2073173282A5056506791 @default.
• W2073173282 hasAuthorship W2073173282A5069705260 @default.
• W2073173282 hasBestOaLocation W20731732821 @default.
• W2073173282 hasConcept C101425835 @default.
• W2073173282 hasConcept C104317684 @default.
• W2073173282 hasConcept C12455157 @default.
• W2073173282 hasConcept C141231307 @default.
• W2073173282 hasConcept C154945302 @default.
• W2073173282 hasConcept C157887575 @default.
• W2073173282 hasConcept C172510086 @default.
• W2073173282 hasConcept C41008148 @default.
• W2073173282 hasConcept C4918238 @default.
• W2073173282 hasConcept C51603236 @default.
• W2073173282 hasConcept C54355233 @default.
• W2073173282 hasConcept C70721500 @default.
• W2073173282 hasConcept C86803240 @default.
• W2073173282 hasConceptScore W2073173282C101425835 @default.
• W2073173282 hasConceptScore W2073173282C104317684 @default.
• W2073173282 hasConceptScore W2073173282C12455157 @default.
• W2073173282 hasConceptScore W2073173282C141231307 @default.
• W2073173282 hasConceptScore W2073173282C154945302 @default.
• W2073173282 hasConceptScore W2073173282C157887575 @default.
• W2073173282 hasConceptScore W2073173282C172510086 @default.
• W2073173282 hasConceptScore W2073173282C41008148 @default.
• W2073173282 hasConceptScore W2073173282C4918238 @default.
• W2073173282 hasConceptScore W2073173282C51603236 @default.
• W2073173282 hasConceptScore W2073173282C54355233 @default.
• W2073173282 hasConceptScore W2073173282C70721500 @default.
• W2073173282 hasConceptScore W2073173282C86803240 @default.
• W2073173282 hasIssue "8" @default.
• W2073173282 hasLocation W20731732821 @default.
• W2073173282 hasLocation W20731732822 @default.
• W2073173282 hasLocation W20731732823 @default.

• next