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- W2073547487 abstract "Abstract It has been shown in this study that granulocytic chalone inhibits DNA synthesis in normal and leukaemic cells (chloroleukaemia in rat and chronic myeloid leukaemia in man), and that this inhibition is tissue specific to the granulocytic system. In contrast to this granulocytic chalone is not species specific either in respect to its origin or to its inhibitory action. The most important result of the present study is the demonstration that generalized leukaemia in rat (chloroleukaemia) can be completely and permanently cured by means of the granulocytic chalone. With the maximum dose used in this study the survival time was prolonged in all the treated rats and in 9 animals out of the 40 the leukaemia disappeared completely and permanently. The implication from the in vitro results with rat and man and from the in vivo results with rat is that cures of leukaemia may also be obtained on man." @default.
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- W2073547487 date "1970-10-01" @default.
- W2073547487 modified "2023-09-27" @default.
- W2073547487 title "Regression of generalized leukaemia in rat induced by the granulocytic chalone" @default.
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- W2073547487 doi "https://doi.org/10.1016/0014-2964(70)90038-1" @default.
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