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- W2073552996 abstract "Norwalk virus, the prototype norovirus, was identified in 1972 by the late Albert Kapikian in a fecal sample from an outbreak of acute gastroenteritis at an elementary school in Norwalk, Ohio, USA. 1 Kapikian AZ Wyatt RG Dolin R Thornhill TS Kalica AR Chanock RM Visualization by immune electron microscopy of a 27-nm particle associated with acute infectious nonbacterial gastroenteritis. J Virol. 1972; 10: 1075-1081 Crossref PubMed Google Scholar During this outbreak, almost 50% of the students and teachers were infected during 2 days, highlighting the rapid spread of norovirus outbreaks. The advent and wide availability of molecular diagnostic techniques has resulted in increased awareness of the importance of norovirus-associated acute gastroenteritis. By contrast with rotaviruses, which were identified in 1973, 2 Bishop RF Davidson GP Holmes IH Ruck BJ Virus particles in epithelial cells of duodenal mucosa from children with acute non-bacterial gastroenteritis. Lancet. 1973; 2: 1281-1283 Summary PubMed Scopus (663) Google Scholar , 3 Flewett TH Bryden AS Davies H Letter: Virus particles in gastroenteritis. Lancet. 1973; 2: 1497 Abstract PubMed Google Scholar and widely accepted as the leading cause of viral gastroenteritis in children, noroviruses have been second in line. With the worldwide availability of rotavirus vaccination, this situation seems to be changing. Global prevalence of norovirus in cases of gastroenteritis: a systematic review and meta-analysisNorovirus is a key gastroenteritis pathogen associated with almost a fifth of all cases of acute gastroenteritis, and targeted intervention to reduce norovirus burden, such as vaccines, should be considered. Full-Text PDF" @default.
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- W2073552996 date "2014-08-01" @default.
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- W2073552996 title "Noroviruses: a global cause of acute gastroenteritis" @default.
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- W2073552996 doi "https://doi.org/10.1016/s1473-3099(14)70776-5" @default.
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