FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2074578477> ?p ?o ?g. }

• W2074578477 endingPage "725" @default.
• W2074578477 startingPage "721" @default.
• W2074578477 abstract "Williams syndrome (WS) is a neurodevelopmental disorder resulting from a hemizygous deletion of chromosome 7q11.23. The phenotype of WS consists of typical dysmorphic features, supravalvular aortic stenosis, infantile hypercalcemia and growth retardation. While language and facial recognition seem to be relatively spared, visuospatial constructive disabilities are a hallmark of the neurobehavioral profile of WS. In order to search for actual structural abnormalities underlying this precisely defined neurodevelopmental disorder, we performed anatomical magnetic resonance imaging (MRI) in 9 WS children (11.6 ± 3.1 years; age range: 5.5–15 years) and 11 normal age-matched control children (11.8 ± 2.2 years; age range: 8–15 years) using voxel-based morphometry (VBM). VBM is a fully automated whole-brain technique that delivers a voxel-wise assessment of regional grey and white matter concentration. A significant decrease in grey matter concentration was detected in the left parieto-occipital region of WS children (P < 0.05 corrected height threshold). The location of this abnormality in WS children coincides with the location of the structural abnormality previously described using the same method in 13 WS adults. These parieto-occipital abnormalities are consistent with the cognitive profile of WS which includes severe visuospatial construction and numerical cognition deficits. The demonstration of identical structural abnormalities in both adults and children argues for their early origin. Additionally, our study provides support for the use of advanced structural imaging techniques in children, in order to improve our understanding of neurobehavioral phenotypes associated with well-defined genetic disorders." @default.
• W2074578477 created "2016-06-24" @default.
• W2074578477 creator A5003667456 @default.
• W2074578477 creator A5025944849 @default.
• W2074578477 creator A5029343002 @default.
• W2074578477 creator A5046900294 @default.
• W2074578477 creator A5047685808 @default.
• W2074578477 creator A5053340571 @default.
• W2074578477 creator A5074116791 @default.
• W2074578477 creator A5082991071 @default.
• W2074578477 date "2006-04-01" @default.
• W2074578477 modified "2023-10-16" @default.
• W2074578477 title "Parieto-occipital grey matter abnormalities in children with Williams syndrome" @default.
• W2074578477 cites W1965007620 @default.
• W2074578477 cites W1987221082 @default.
• W2074578477 cites W1987588414 @default.
• W2074578477 cites W1993056927 @default.
• W2074578477 cites W2016582493 @default.
• W2074578477 cites W2017033114 @default.
• W2074578477 cites W2020789214 @default.
• W2074578477 cites W2023896775 @default.
• W2074578477 cites W2034272010 @default.
• W2074578477 cites W2053992400 @default.
• W2074578477 cites W2062811638 @default.
• W2074578477 cites W2066795020 @default.
• W2074578477 cites W2073165656 @default.
• W2074578477 cites W2073895292 @default.
• W2074578477 cites W2097106481 @default.
• W2074578477 cites W2099388927 @default.
• W2074578477 cites W2107774326 @default.
• W2074578477 cites W2115229328 @default.
• W2074578477 cites W2116649573 @default.
• W2074578477 cites W2118421222 @default.
• W2074578477 cites W2119848633 @default.
• W2074578477 cites W2123761308 @default.
• W2074578477 cites W2129092131 @default.
• W2074578477 cites W2138121552 @default.
• W2074578477 cites W2141475257 @default.
• W2074578477 cites W2152292563 @default.
• W2074578477 cites W2152924070 @default.
• W2074578477 cites W2154686098 @default.
• W2074578477 cites W2164126020 @default.
• W2074578477 cites W4250333762 @default.
• W2074578477 cites W4251661431 @default.
• W2074578477 cites W4253216993 @default.
• W2074578477 doi "https://doi.org/10.1016/j.neuroimage.2005.10.051" @default.
• W2074578477 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16380272" @default.
• W2074578477 hasPublicationYear "2006" @default.
• W2074578477 type Work @default.
• W2074578477 sameAs 2074578477 @default.
• W2074578477 citedByCount "69" @default.
• W2074578477 countsByYear W20745784772012 @default.
• W2074578477 countsByYear W20745784772013 @default.
• W2074578477 countsByYear W20745784772014 @default.
• W2074578477 countsByYear W20745784772016 @default.
• W2074578477 countsByYear W20745784772019 @default.
• W2074578477 countsByYear W20745784772020 @default.
• W2074578477 countsByYear W20745784772023 @default.
• W2074578477 crossrefType "journal-article" @default.
• W2074578477 hasAuthorship W2074578477A5003667456 @default.
• W2074578477 hasAuthorship W2074578477A5025944849 @default.
• W2074578477 hasAuthorship W2074578477A5029343002 @default.
• W2074578477 hasAuthorship W2074578477A5046900294 @default.
• W2074578477 hasAuthorship W2074578477A5047685808 @default.
• W2074578477 hasAuthorship W2074578477A5053340571 @default.
• W2074578477 hasAuthorship W2074578477A5074116791 @default.
• W2074578477 hasAuthorship W2074578477A5082991071 @default.
• W2074578477 hasConcept C118552586 @default.
• W2074578477 hasConcept C126838900 @default.
• W2074578477 hasConcept C138496976 @default.
• W2074578477 hasConcept C143409427 @default.
• W2074578477 hasConcept C15744967 @default.
• W2074578477 hasConcept C169760540 @default.
• W2074578477 hasConcept C169900460 @default.
• W2074578477 hasConcept C200134340 @default.
• W2074578477 hasConcept C205778803 @default.
• W2074578477 hasConcept C2778013878 @default.
• W2074578477 hasConcept C2779388368 @default.
• W2074578477 hasConcept C2781192897 @default.
• W2074578477 hasConcept C2781240822 @default.
• W2074578477 hasConcept C50965678 @default.
• W2074578477 hasConcept C54170458 @default.
• W2074578477 hasConcept C548259974 @default.
• W2074578477 hasConcept C71924100 @default.
• W2074578477 hasConceptScore W2074578477C118552586 @default.
• W2074578477 hasConceptScore W2074578477C126838900 @default.
• W2074578477 hasConceptScore W2074578477C138496976 @default.
• W2074578477 hasConceptScore W2074578477C143409427 @default.
• W2074578477 hasConceptScore W2074578477C15744967 @default.
• W2074578477 hasConceptScore W2074578477C169760540 @default.
• W2074578477 hasConceptScore W2074578477C169900460 @default.
• W2074578477 hasConceptScore W2074578477C200134340 @default.
• W2074578477 hasConceptScore W2074578477C205778803 @default.
• W2074578477 hasConceptScore W2074578477C2778013878 @default.
• W2074578477 hasConceptScore W2074578477C2779388368 @default.
• W2074578477 hasConceptScore W2074578477C2781192897 @default.
• W2074578477 hasConceptScore W2074578477C2781240822 @default.
• W2074578477 hasConceptScore W2074578477C50965678 @default.

• next