Matches in SemOpenAlex for { <https://semopenalex.org/work/W2075244928> ?p ?o ?g. }
- W2075244928 endingPage "1085" @default.
- W2075244928 startingPage "1071" @default.
- W2075244928 abstract "Background: Although catalytic RNA enzymes (CRzs) are naturally occurring in many organisms, their DNA counterparts (CDzs) were developed by in vitro selection/evolution from random sequence libraries. Objective: To provide a brief overview of how CDzs have been selected in vitro, and of their properties and functions, as well as their possible future utility. Methods: We concentrated on examples of ‘direct’ selection of CDzs. Many CDzs have been used in biological settings, for example downregulation of target mRNAs, while many more recent applications use CDzs in biosensor and nanotechnology settings. Conclusions: Although much work has concentrated on using CDzs for regulating gene expression, their potential as nucleic acid medicines has diminished substantially, supplanted by simple antisense oligonucleotides and, more recently, by small interfering RNAs (siRNAs). It seems unlikely that CDzs will have clinical utility. In contrast, they are likely to have significant potential in the sensor/nanotechnology arena." @default.
- W2075244928 created "2016-06-24" @default.
- W2075244928 creator A5004380039 @default.
- W2075244928 creator A5083391540 @default.
- W2075244928 date "2008-07-09" @default.
- W2075244928 modified "2023-10-03" @default.
- W2075244928 title "Catalytic DNAzymes: derivations and functions" @default.
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