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- W2076561604 endingPage "4569" @default.
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- W2076561604 abstract "DNA transcription depends on multimeric RNA polymerases that are exceptionally conserved in all cellular organisms, with an active site region of >500 amino acids mainly harboured by their Rpb1 and Rpb2 subunits. Together with the distantly related eukaryotic RNA-dependent polymerases involved in gene silencing, they form a monophyletic family of ribonucleotide polymerases with a similarly organized active site region based on two double-Psi barrels. Recent viral and phage genome sequencing have added a surprising variety of putative nucleotide polymerases to this protein family. These proteins have highly divergent subunit composition and amino acid sequences, but always contain eight invariant amino acids forming a universally conserved catalytic site shared by all members of the two-barrel protein family. Moreover, the highly conserved 'funnel' and 'switch 2' components of the active site region are shared by all putative DNA-dependent RNA polymerases and may thus determine their capacity to transcribe double-stranded DNA templates." @default.
- W2076561604 created "2016-06-24" @default.
- W2076561604 creator A5025635364 @default.
- W2076561604 creator A5035322069 @default.
- W2076561604 date "2010-03-31" @default.
- W2076561604 modified "2023-09-30" @default.
- W2076561604 title "Non-canonical DNA transcription enzymes and the conservation of two-barrel RNA polymerases" @default.
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- W2076561604 doi "https://doi.org/10.1093/nar/gkq201" @default.
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