Matches in SemOpenAlex for { <https://semopenalex.org/work/W2076845530> ?p ?o ?g. }
- W2076845530 abstract "Food-derived bioactive peptides are reported to express a variety of functions in vivo. We studied the in vitro effect of three bioactive tripeptides, isoleucine-proline-proline (IPP), valine-proline-proline (VPP) and leucine-lysine-proline (LKP), on osteoblast proliferation and gene expression. We used UMR-106 osteosarcoma cells, human marrow-derived mesenchymal stem cells (hMSC) and osteoblasts differentiated from hMSC. Treatment with 50 mum-IPP increased UMR-106 cell and hMSC proliferation. The gene expression of hMSC-differentiated osteoblasts was analysed by the microarray method. Microarray analysis revealed that IPP up-regulated 270 genes and down-regulated 100 genes. VPP and LKP, by contrast, had a very modest influence on osteoblast gene expression. Real-time PCR confirmed that IPP up-regulated PTHrP, BMP-5 and CREB-5 and down-regulated VDR and caspase-8. IPP possesses potential to increase osteoblast proliferation, differentiation and signalling. Agents that increase the number and function of osteoblasts could improve bone mass and structure, and decrease fracture risk." @default.
- W2076845530 created "2016-06-24" @default.
- W2076845530 creator A5023981414 @default.
- W2076845530 creator A5035670155 @default.
- W2076845530 creator A5036783661 @default.
- W2076845530 creator A5049140887 @default.
- W2076845530 date "2007-04-30" @default.
- W2076845530 modified "2023-09-27" @default.
- W2076845530 title "Effects of bioactive peptides isoleucine-proline-proline (IPP), valine-proline-proline (VPP) and leucine-lysine-proline (LKP) on gene expression of osteoblasts differentiated from human mesenchymal stem cells" @default.
- W2076845530 cites W1508777555 @default.
- W2076845530 cites W1555766099 @default.
- W2076845530 cites W1907708899 @default.
- W2076845530 cites W191290535 @default.
- W2076845530 cites W1939082511 @default.
- W2076845530 cites W1973256712 @default.
- W2076845530 cites W1974852089 @default.
- W2076845530 cites W1976179916 @default.
- W2076845530 cites W1980225254 @default.
- W2076845530 cites W1980945609 @default.
- W2076845530 cites W1982812308 @default.
- W2076845530 cites W1984153473 @default.
- W2076845530 cites W1987093863 @default.
- W2076845530 cites W1999666161 @default.
- W2076845530 cites W2010792902 @default.
- W2076845530 cites W2012764005 @default.
- W2076845530 cites W2023065215 @default.
- W2076845530 cites W2030857499 @default.
- W2076845530 cites W2040874423 @default.
- W2076845530 cites W2042559028 @default.
- W2076845530 cites W2042861901 @default.
- W2076845530 cites W2046556375 @default.
- W2076845530 cites W2046819829 @default.
- W2076845530 cites W2053460039 @default.
- W2076845530 cites W2061108911 @default.
- W2076845530 cites W2072510100 @default.
- W2076845530 cites W2075292460 @default.
- W2076845530 cites W2075819111 @default.
- W2076845530 cites W2076392488 @default.
- W2076845530 cites W2086982197 @default.
- W2076845530 cites W2087623555 @default.
- W2076845530 cites W2087658867 @default.
- W2076845530 cites W2092994596 @default.
- W2076845530 cites W2093360232 @default.
- W2076845530 cites W2098267165 @default.
- W2076845530 cites W2110149781 @default.
- W2076845530 cites W2124240756 @default.
- W2076845530 cites W2133900042 @default.
- W2076845530 cites W2139462080 @default.
- W2076845530 cites W2162169788 @default.
- W2076845530 cites W2166919582 @default.
- W2076845530 cites W2170080359 @default.
- W2076845530 cites W2183731245 @default.
- W2076845530 cites W4242842840 @default.
- W2076845530 doi "https://doi.org/10.1017/s0007114507744434" @default.
- W2076845530 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17466096" @default.
- W2076845530 hasPublicationYear "2007" @default.
- W2076845530 type Work @default.
- W2076845530 sameAs 2076845530 @default.
- W2076845530 citedByCount "22" @default.
- W2076845530 countsByYear W20768455302012 @default.
- W2076845530 countsByYear W20768455302014 @default.
- W2076845530 countsByYear W20768455302016 @default.
- W2076845530 countsByYear W20768455302017 @default.
- W2076845530 countsByYear W20768455302018 @default.
- W2076845530 countsByYear W20768455302019 @default.
- W2076845530 countsByYear W20768455302021 @default.
- W2076845530 countsByYear W20768455302022 @default.
- W2076845530 countsByYear W20768455302023 @default.
- W2076845530 crossrefType "journal-article" @default.
- W2076845530 hasAuthorship W2076845530A5023981414 @default.
- W2076845530 hasAuthorship W2076845530A5035670155 @default.
- W2076845530 hasAuthorship W2076845530A5036783661 @default.
- W2076845530 hasAuthorship W2076845530A5049140887 @default.
- W2076845530 hasBestOaLocation W20768455301 @default.
- W2076845530 hasConcept C104317684 @default.
- W2076845530 hasConcept C131075544 @default.
- W2076845530 hasConcept C148738053 @default.
- W2076845530 hasConcept C153911025 @default.
- W2076845530 hasConcept C160160445 @default.
- W2076845530 hasConcept C181199279 @default.
- W2076845530 hasConcept C185592680 @default.
- W2076845530 hasConcept C198826908 @default.
- W2076845530 hasConcept C202751555 @default.
- W2076845530 hasConcept C2777573094 @default.
- W2076845530 hasConcept C2778260815 @default.
- W2076845530 hasConcept C2779815552 @default.
- W2076845530 hasConcept C515207424 @default.
- W2076845530 hasConcept C55493867 @default.
- W2076845530 hasConcept C86803240 @default.
- W2076845530 hasConcept C95444343 @default.
- W2076845530 hasConceptScore W2076845530C104317684 @default.
- W2076845530 hasConceptScore W2076845530C131075544 @default.
- W2076845530 hasConceptScore W2076845530C148738053 @default.
- W2076845530 hasConceptScore W2076845530C153911025 @default.
- W2076845530 hasConceptScore W2076845530C160160445 @default.
- W2076845530 hasConceptScore W2076845530C181199279 @default.
- W2076845530 hasConceptScore W2076845530C185592680 @default.
- W2076845530 hasConceptScore W2076845530C198826908 @default.
- W2076845530 hasConceptScore W2076845530C202751555 @default.
- W2076845530 hasConceptScore W2076845530C2777573094 @default.