Matches in SemOpenAlex for { <https://semopenalex.org/work/W2078764412> ?p ?o ?g. }
Showing items 1 to 92 of
92
with 100 items per page.
- W2078764412 endingPage "402" @default.
- W2078764412 startingPage "395" @default.
- W2078764412 abstract "To investigate the development of intimal hyperplasia in response to percutaneous transluminal coronary angioplasty (PTCA) followed by local delivery of the nitric oxide (NO) donor 3-morpholino-sydnonimine (SIN-1).Overdilation PTCA was performed in coronary arteries in 20 healthy pigs. One of the dilated segments was additionally treated with local delivery of SIN-1 for 10 min. Segments distal to the treated part of the arteries served as controls. Arteries were radiographically depicted and analyzed after 1 and 8 weeks for actin, myosin and intermediate filaments (IF), nitric oxide synthetase (NOS) and histological evaluation.Segments treated with PTCA+SIN-1 showed a significantly (p=0.03) larger luminal diameter compared with PTCA only treated segments. The luminal loss after SIN-1 was not significant compared with the diameter prior to treatment. Endothelial NOS content was significantly lower in the PTCA+SIN-1 group compared with the PTCA group after 1 (p=0.03) and 8 weeks (p=0.013). IF/actin ratio after 1 week was significantly increased in PTCA-treated segments compared with untreated controls (p=0.004), and compared with PTCA+SIN-1-treated segments (p=0.004).PTCA-induced intimal hyperplasia was potently inhibited by local delivery of the NO donor SIN-1. Momentary events at the time of injury play a significant role in the development of intimal hyperplasia and long-lasting down-regulation of the endothelial NOS expression after SIN-1 exposure is suggested. The IF/actin ratio can be useful as an early marker of intimal hyperplasia." @default.
- W2078764412 created "2016-06-24" @default.
- W2078764412 creator A5011250495 @default.
- W2078764412 creator A5021879068 @default.
- W2078764412 creator A5051444095 @default.
- W2078764412 creator A5054512377 @default.
- W2078764412 creator A5056312267 @default.
- W2078764412 creator A5070951902 @default.
- W2078764412 creator A5072796170 @default.
- W2078764412 creator A5081477084 @default.
- W2078764412 date "2003-07-01" @default.
- W2078764412 modified "2023-09-27" @default.
- W2078764412 title "Local Infusion of the Nitric oxide Donor Sin-1 After Angioplasty . Effects on intimal hyperplasia in porcine coronary arteries" @default.
- W2078764412 cites W1821918060 @default.
- W2078764412 cites W1970729969 @default.
- W2078764412 cites W1973263205 @default.
- W2078764412 cites W1988291501 @default.
- W2078764412 cites W1996775097 @default.
- W2078764412 cites W2001531968 @default.
- W2078764412 cites W2010954547 @default.
- W2078764412 cites W2018719870 @default.
- W2078764412 cites W2023472206 @default.
- W2078764412 cites W2035620169 @default.
- W2078764412 cites W2036966111 @default.
- W2078764412 cites W2047246747 @default.
- W2078764412 cites W2050531636 @default.
- W2078764412 cites W2050965064 @default.
- W2078764412 cites W2056367384 @default.
- W2078764412 cites W2063277519 @default.
- W2078764412 cites W2089796673 @default.
- W2078764412 cites W2102369320 @default.
- W2078764412 cites W2102374129 @default.
- W2078764412 cites W2106222736 @default.
- W2078764412 cites W2126590643 @default.
- W2078764412 cites W2153723891 @default.
- W2078764412 doi "https://doi.org/10.1034/j.1600-0455.2003.00079.x" @default.
- W2078764412 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12846690" @default.
- W2078764412 hasPublicationYear "2003" @default.
- W2078764412 type Work @default.
- W2078764412 sameAs 2078764412 @default.
- W2078764412 citedByCount "5" @default.
- W2078764412 crossrefType "journal-article" @default.
- W2078764412 hasAuthorship W2078764412A5011250495 @default.
- W2078764412 hasAuthorship W2078764412A5021879068 @default.
- W2078764412 hasAuthorship W2078764412A5051444095 @default.
- W2078764412 hasAuthorship W2078764412A5054512377 @default.
- W2078764412 hasAuthorship W2078764412A5056312267 @default.
- W2078764412 hasAuthorship W2078764412A5070951902 @default.
- W2078764412 hasAuthorship W2078764412A5072796170 @default.
- W2078764412 hasAuthorship W2078764412A5081477084 @default.
- W2078764412 hasBestOaLocation W20787644122 @default.
- W2078764412 hasConcept C126322002 @default.
- W2078764412 hasConcept C164705383 @default.
- W2078764412 hasConcept C2776820930 @default.
- W2078764412 hasConcept C2778742706 @default.
- W2078764412 hasConcept C2779751240 @default.
- W2078764412 hasConcept C2780326628 @default.
- W2078764412 hasConcept C2992686903 @default.
- W2078764412 hasConcept C519581460 @default.
- W2078764412 hasConcept C71924100 @default.
- W2078764412 hasConceptScore W2078764412C126322002 @default.
- W2078764412 hasConceptScore W2078764412C164705383 @default.
- W2078764412 hasConceptScore W2078764412C2776820930 @default.
- W2078764412 hasConceptScore W2078764412C2778742706 @default.
- W2078764412 hasConceptScore W2078764412C2779751240 @default.
- W2078764412 hasConceptScore W2078764412C2780326628 @default.
- W2078764412 hasConceptScore W2078764412C2992686903 @default.
- W2078764412 hasConceptScore W2078764412C519581460 @default.
- W2078764412 hasConceptScore W2078764412C71924100 @default.
- W2078764412 hasIssue "4" @default.
- W2078764412 hasLocation W20787644121 @default.
- W2078764412 hasLocation W20787644122 @default.
- W2078764412 hasLocation W20787644123 @default.
- W2078764412 hasOpenAccess W2078764412 @default.
- W2078764412 hasPrimaryLocation W20787644121 @default.
- W2078764412 hasRelatedWork W131367721 @default.
- W2078764412 hasRelatedWork W1996477190 @default.
- W2078764412 hasRelatedWork W2027791684 @default.
- W2078764412 hasRelatedWork W2056910106 @default.
- W2078764412 hasRelatedWork W2074719251 @default.
- W2078764412 hasRelatedWork W2078764412 @default.
- W2078764412 hasRelatedWork W2080648445 @default.
- W2078764412 hasRelatedWork W2415536367 @default.
- W2078764412 hasRelatedWork W3107105643 @default.
- W2078764412 hasRelatedWork W77699174 @default.
- W2078764412 hasVolume "44" @default.
- W2078764412 isParatext "false" @default.
- W2078764412 isRetracted "false" @default.
- W2078764412 magId "2078764412" @default.
- W2078764412 workType "article" @default.