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- W2078869722 abstract "Opioid receptor binding, including the mu, delta, and kappa receptor subtypes, was compared in morphine-injected and control rats. Brain tissues were homogenized and centrifuged either one or two times prior to receptor binding assay. In brain membranes from morphine-injected rats centrifuged once, there was a decrease in mu, but not delta or kappa, binding compared to controls, perhaps indicating occupation of these sites by morphine. By contrast, homogenates from morphine-injected rats centrifuged twice manifested an increase inmu, but not delta or kappa, binding sites. These results suggest that pharmacological stimulation of central opioid receptors with morphine causes a rapid, selective increase in the number of available mu binding sites." @default.
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- W2078869722 date "1984-12-01" @default.
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- W2078869722 title "Acute systemic administration of morphine selectively increases mu opioid receptor binding in the rat brain" @default.
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- W2078869722 doi "https://doi.org/10.1016/0143-4179(84)90041-6" @default.
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