Matches in SemOpenAlex for { <https://semopenalex.org/work/W2079244861> ?p ?o ?g. }
- W2079244861 endingPage "1183" @default.
- W2079244861 startingPage "1171" @default.
- W2079244861 abstract "The maintenance of pluripotency in mouse embryonic stem cells (mESCs) relies on the activity of a transcriptional network that is fuelled by the activity of three transcription factors (Nanog, Oct4 and Sox2) and balanced by the repressive activity of Tcf3. Extracellular signals modulate the activity of the network and regulate the differentiation capacity of the cells. Wnt/β-catenin signaling has emerged as a significant potentiator of pluripotency: increases in the levels of β-catenin regulate the activity of Oct4 and Nanog, and enhance pluripotency. A recent report shows that β-catenin achieves some of these effects by modulating the activity of Tcf3, and that this effect does not require its transcriptional activation domain. Here, we show that during self-renewal there is negligible transcriptional activity of β-catenin and that this is due to its tight association with membranes, where we find it in a complex with Oct4 and E-cadherin. Differentiation triggers a burst of Wnt/β-catenin transcriptional activity that coincides with the disassembly of the complex. Our results establish that β-catenin, but not its transcriptional activity, is central to pluripotency acting through a β-catenin/Oct4 complex." @default.
- W2079244861 created "2016-06-24" @default.
- W2079244861 creator A5007538021 @default.
- W2079244861 creator A5012382489 @default.
- W2079244861 creator A5012706612 @default.
- W2079244861 creator A5014695527 @default.
- W2079244861 creator A5019486463 @default.
- W2079244861 creator A5020493466 @default.
- W2079244861 creator A5064784533 @default.
- W2079244861 creator A5066926440 @default.
- W2079244861 creator A5068968166 @default.
- W2079244861 creator A5072171666 @default.
- W2079244861 creator A5091374865 @default.
- W2079244861 date "2013-03-15" @default.
- W2079244861 modified "2023-10-03" @default.
- W2079244861 title "A membrane-associated β-catenin/Oct4 complex correlates with ground-state pluripotency in mouse embryonic stem cells" @default.
- W2079244861 cites W1485990469 @default.
- W2079244861 cites W1599153377 @default.
- W2079244861 cites W1608762409 @default.
- W2079244861 cites W1966758700 @default.
- W2079244861 cites W1970632237 @default.
- W2079244861 cites W1972343960 @default.
- W2079244861 cites W1975023735 @default.
- W2079244861 cites W1976359234 @default.
- W2079244861 cites W1982624893 @default.
- W2079244861 cites W1982748372 @default.
- W2079244861 cites W1990577927 @default.
- W2079244861 cites W1992949513 @default.
- W2079244861 cites W1993103415 @default.
- W2079244861 cites W1994822723 @default.
- W2079244861 cites W1995771651 @default.
- W2079244861 cites W1996984755 @default.
- W2079244861 cites W1997054356 @default.
- W2079244861 cites W1998694879 @default.
- W2079244861 cites W2002511118 @default.
- W2079244861 cites W2017050785 @default.
- W2079244861 cites W2018765068 @default.
- W2079244861 cites W2021226225 @default.
- W2079244861 cites W2025102507 @default.
- W2079244861 cites W2035047647 @default.
- W2079244861 cites W2037128138 @default.
- W2079244861 cites W2038833190 @default.
- W2079244861 cites W2041472984 @default.
- W2079244861 cites W2042102680 @default.
- W2079244861 cites W2051104316 @default.
- W2079244861 cites W2053378592 @default.
- W2079244861 cites W2053911973 @default.
- W2079244861 cites W2057257265 @default.
- W2079244861 cites W2058010162 @default.
- W2079244861 cites W2058421656 @default.
- W2079244861 cites W2058521801 @default.
- W2079244861 cites W2062096656 @default.
- W2079244861 cites W2064031857 @default.
- W2079244861 cites W2064736822 @default.
- W2079244861 cites W2066307520 @default.
- W2079244861 cites W2066911215 @default.
- W2079244861 cites W2067056027 @default.
- W2079244861 cites W2069096667 @default.
- W2079244861 cites W2071497196 @default.
- W2079244861 cites W2072896199 @default.
- W2079244861 cites W2075564625 @default.
- W2079244861 cites W2077845288 @default.
- W2079244861 cites W2078093070 @default.
- W2079244861 cites W2078807740 @default.
- W2079244861 cites W2081985759 @default.
- W2079244861 cites W2083935868 @default.
- W2079244861 cites W2086306726 @default.
- W2079244861 cites W2089426706 @default.
- W2079244861 cites W2089434899 @default.
- W2079244861 cites W2090325313 @default.
- W2079244861 cites W2090400362 @default.
- W2079244861 cites W2094831008 @default.
- W2079244861 cites W2096857560 @default.
- W2079244861 cites W2097946485 @default.
- W2079244861 cites W2098717020 @default.
- W2079244861 cites W2105361655 @default.
- W2079244861 cites W2107575419 @default.
- W2079244861 cites W2107648723 @default.
- W2079244861 cites W2109794889 @default.
- W2079244861 cites W2112350806 @default.
- W2079244861 cites W2117330555 @default.
- W2079244861 cites W2118252933 @default.
- W2079244861 cites W2119284420 @default.
- W2079244861 cites W2125987139 @default.
- W2079244861 cites W2134195865 @default.
- W2079244861 cites W2135407249 @default.
- W2079244861 cites W2141175150 @default.
- W2079244861 cites W2142806844 @default.
- W2079244861 cites W2143972874 @default.
- W2079244861 cites W2146839729 @default.
- W2079244861 cites W2148272837 @default.
- W2079244861 cites W2149159173 @default.
- W2079244861 cites W2149660935 @default.
- W2079244861 cites W2151870437 @default.
- W2079244861 cites W2152589171 @default.
- W2079244861 cites W2157790821 @default.
- W2079244861 cites W2158021558 @default.
- W2079244861 cites W2161594343 @default.