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- W2079404188 abstract "In difficult cases of congenital adrenal hyperplasia (CAH), often the child may have normal cortisol levels and elevated androgen levels, or normal androgen levels and elevated cortisol levels, but not normal levels of both. Because bilateral adrenalectomy removes the source of the abnormal androgen production, the authors felt that in some cases it might be more efficacious than conventional medical therapy.Three children with CAH and suboptimal response to medical management underwent bilateral laparoscopic adrenalectomy. Parents were counseled extensively regarding the experimental nature of this treatment and the potential long-term complications.All children recovered quickly after a mean hospital stay of 1.8 days. Pathologic examination of the removed adrenal glands showed persistent cortical hyperplasia. Follow-up at 6 months indicated marked reduction in abnormal androgen production, which allowed lowering of the steroid dosing to physiologic levels.In children with CAH refractory to medical management, bilateral laparoscopic adrenalectomy can be performed safely with almost trivial morbidity. Although early results are very encouraging, the anticipated long-term beneficial effects on growth, short stature, and adult infertility will require years to assess." @default.
- W2079404188 created "2016-06-24" @default.
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- W2079404188 date "2000-11-01" @default.
- W2079404188 modified "2023-09-24" @default.
- W2079404188 title "Bilateral laparoscopic adrenalectomy: A new treatment for difficult cases of congenital adrenal hyperplasia" @default.
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- W2079404188 doi "https://doi.org/10.1053/jpsu.2000.18321" @default.
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