Matches in SemOpenAlex for { <https://semopenalex.org/work/W2079593771> ?p ?o ?g. }
- W2079593771 endingPage "249" @default.
- W2079593771 startingPage "245" @default.
- W2079593771 abstract "The effects of squalestatin 1 on rat brain and liver homogenates and on Chinese hamster ovary tissue culture cells have been investigated. This compound effectively inhibits squalene biosynthesis in a highly selective manner. Cytoplasmic farnesyl pyrophosphate and geranylgeranyl pyrophosphate synthases are not affected, which is also the case for microsomal cis-prenyltransferase. In tissue culture cells, squalestatin 1 inhibits cholesterol biosynthesis completely, but does not alter dolichol synthesis or protein isoprenylation to a great extent. Incorporation of [3H]mevalonate into ubiquinone-9 and -10 increases 3–4-fold, probably as a result of increased synthesis of this lipid. Squalestatin 1 appears not only to be an effective inhibitor of cholesterol biosynthesis, but also to be more specific than other inhibitors used earlier in various in vitro and in vivo systems." @default.
- W2079593771 created "2016-06-24" @default.
- W2079593771 creator A5004126862 @default.
- W2079593771 creator A5032115952 @default.
- W2079593771 creator A5046317472 @default.
- W2079593771 creator A5049502167 @default.
- W2079593771 creator A5054499724 @default.
- W2079593771 creator A5069293832 @default.
- W2079593771 date "1994-12-01" @default.
- W2079593771 modified "2023-10-16" @default.
- W2079593771 title "Effect of squalestatin 1 on the biosynthesis of the mevalonate pathway lipids" @default.
- W2079593771 cites W127937226 @default.
- W2079593771 cites W1500251414 @default.
- W2079593771 cites W1514061196 @default.
- W2079593771 cites W1547467983 @default.
- W2079593771 cites W1551571847 @default.
- W2079593771 cites W1569834708 @default.
- W2079593771 cites W1593369110 @default.
- W2079593771 cites W1611096381 @default.
- W2079593771 cites W1775749144 @default.
- W2079593771 cites W1998717932 @default.
- W2079593771 cites W2002349781 @default.
- W2079593771 cites W2023393277 @default.
- W2079593771 cites W2040701832 @default.
- W2079593771 cites W2044317999 @default.
- W2079593771 cites W2071124826 @default.
- W2079593771 cites W2093673234 @default.
- W2079593771 cites W2100837269 @default.
- W2079593771 cites W2148463229 @default.
- W2079593771 cites W2153435788 @default.
- W2079593771 cites W2166483827 @default.
- W2079593771 cites W2178557511 @default.
- W2079593771 cites W2330206990 @default.
- W2079593771 cites W2395115172 @default.
- W2079593771 cites W2510632509 @default.
- W2079593771 cites W3118895760 @default.
- W2079593771 cites W64228731 @default.
- W2079593771 doi "https://doi.org/10.1016/0005-2760(94)90049-3" @default.
- W2079593771 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7811707" @default.
- W2079593771 hasPublicationYear "1994" @default.
- W2079593771 type Work @default.
- W2079593771 sameAs 2079593771 @default.
- W2079593771 citedByCount "30" @default.
- W2079593771 countsByYear W20795937712013 @default.
- W2079593771 countsByYear W20795937712018 @default.
- W2079593771 countsByYear W20795937712021 @default.
- W2079593771 crossrefType "journal-article" @default.
- W2079593771 hasAuthorship W2079593771A5004126862 @default.
- W2079593771 hasAuthorship W2079593771A5032115952 @default.
- W2079593771 hasAuthorship W2079593771A5046317472 @default.
- W2079593771 hasAuthorship W2079593771A5049502167 @default.
- W2079593771 hasAuthorship W2079593771A5054499724 @default.
- W2079593771 hasAuthorship W2079593771A5069293832 @default.
- W2079593771 hasConcept C150903083 @default.
- W2079593771 hasConcept C170493617 @default.
- W2079593771 hasConcept C175656101 @default.
- W2079593771 hasConcept C181199279 @default.
- W2079593771 hasConcept C185592680 @default.
- W2079593771 hasConcept C202751555 @default.
- W2079593771 hasConcept C207001950 @default.
- W2079593771 hasConcept C2776085463 @default.
- W2079593771 hasConcept C2776703722 @default.
- W2079593771 hasConcept C2776990775 @default.
- W2079593771 hasConcept C2777654137 @default.
- W2079593771 hasConcept C2778163477 @default.
- W2079593771 hasConcept C2778396349 @default.
- W2079593771 hasConcept C2778718757 @default.
- W2079593771 hasConcept C2778827360 @default.
- W2079593771 hasConcept C2779716203 @default.
- W2079593771 hasConcept C2779969316 @default.
- W2079593771 hasConcept C2779982574 @default.
- W2079593771 hasConcept C2780361610 @default.
- W2079593771 hasConcept C2781446604 @default.
- W2079593771 hasConcept C553450214 @default.
- W2079593771 hasConcept C55493867 @default.
- W2079593771 hasConcept C57790582 @default.
- W2079593771 hasConcept C86803240 @default.
- W2079593771 hasConcept C87644729 @default.
- W2079593771 hasConceptScore W2079593771C150903083 @default.
- W2079593771 hasConceptScore W2079593771C170493617 @default.
- W2079593771 hasConceptScore W2079593771C175656101 @default.
- W2079593771 hasConceptScore W2079593771C181199279 @default.
- W2079593771 hasConceptScore W2079593771C185592680 @default.
- W2079593771 hasConceptScore W2079593771C202751555 @default.
- W2079593771 hasConceptScore W2079593771C207001950 @default.
- W2079593771 hasConceptScore W2079593771C2776085463 @default.
- W2079593771 hasConceptScore W2079593771C2776703722 @default.
- W2079593771 hasConceptScore W2079593771C2776990775 @default.
- W2079593771 hasConceptScore W2079593771C2777654137 @default.
- W2079593771 hasConceptScore W2079593771C2778163477 @default.
- W2079593771 hasConceptScore W2079593771C2778396349 @default.
- W2079593771 hasConceptScore W2079593771C2778718757 @default.
- W2079593771 hasConceptScore W2079593771C2778827360 @default.
- W2079593771 hasConceptScore W2079593771C2779716203 @default.
- W2079593771 hasConceptScore W2079593771C2779969316 @default.
- W2079593771 hasConceptScore W2079593771C2779982574 @default.
- W2079593771 hasConceptScore W2079593771C2780361610 @default.
- W2079593771 hasConceptScore W2079593771C2781446604 @default.