FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2080167811> ?p ?o ?g. }

• W2080167811 endingPage "227" @default.
• W2080167811 startingPage "218" @default.
• W2080167811 abstract "Salvia miltiorrhiza (SM, also known as DanShen) is one of the well-known widely used Chinese herbal medicines in clinical, containing phenolic compounds and potent antioxidant properties. Salvianolic acid A (SAA) is the most potent component of SM. A modern experimental strategy for treating myocardial ischemia is to induce neovascularization of the heart by the use of angiogens, mediators that induce the formation of blood vessels, or angiogenesis. Studies demonstrated that coronary collateral vessels protect ischemic myocardium after coronary obstruction; therefore, we sought to examine whether SAA could stimulate myocardial angiogenesis. Male Sprague–Dawley rats myocardial infarct (MI) induced by ligation of left anterior descending coronary artery (LAD) were randomly divided into five groups: sham-operated group; LAD occlusion + administration of physiological saline (vehicle treated group); LAD occlusion + administration of different concentrations of SAA (10, 5.0 and 2.5 mg/kg/d). Infarct size and capillary density in the infarct region were measured with a previous experimental method. Immunohistological analysis was performed to measure vascular endothelial growth factor (VEGF) and vascular endothelial growth factor receptor-2 (VEGFR-2) expressions. The secretion of matrix metalloproteinase type X (MMP-9) was evaluated in serum of post-ischemic rats. We also performed the experiments of SAA on rat endothelial progenitor cells (EPCs) numbers and the capacity of migration and vasculargenesis. SAA potentiated the ischemia-induced neovascularization after 1 week post-operation when compared to vehicle treated group. This effect could be attributed to an increased formation of VEGF, VEGFR-2, and MMP-9 as well as the promotion of numbers and functions of EPCs. These findings show that SAA has potent proangiogenic properties by promoting the expression of proangiogenic factors, and the functions of EPCs, indicating that SAA might contribute to the protective effect against coronary disease. Chemical compound studied in this paper is salvianolic acid A (PubChem CID: 5281793)" @default.
• W2080167811 created "2016-06-24" @default.
• W2080167811 creator A5071178564 @default.
• W2080167811 creator A5073214484 @default.
• W2080167811 creator A5083946842 @default.
• W2080167811 date "2014-01-01" @default.
• W2080167811 modified "2023-09-27" @default.
• W2080167811 title "Salvianolic acid A promotes the acceleration of neovascularization in the ischemic rat myocardium and the functions of endothelial progenitor cells" @default.
• W2080167811 cites W1485875137 @default.
• W2080167811 cites W1494887343 @default.
• W2080167811 cites W1574172480 @default.
• W2080167811 cites W1969779818 @default.
• W2080167811 cites W1972149727 @default.
• W2080167811 cites W1982799013 @default.
• W2080167811 cites W2007939201 @default.
• W2080167811 cites W2011849709 @default.
• W2080167811 cites W2020919781 @default.
• W2080167811 cites W2025425480 @default.
• W2080167811 cites W2026858581 @default.
• W2080167811 cites W2034242203 @default.
• W2080167811 cites W2038298131 @default.
• W2080167811 cites W2046617955 @default.
• W2080167811 cites W2047256840 @default.
• W2080167811 cites W2050709789 @default.
• W2080167811 cites W2050834003 @default.
• W2080167811 cites W2059633155 @default.
• W2080167811 cites W2081570599 @default.
• W2080167811 cites W2084740377 @default.
• W2080167811 cites W2093141143 @default.
• W2080167811 cites W2102271025 @default.
• W2080167811 cites W2106770941 @default.
• W2080167811 cites W2108083474 @default.
• W2080167811 cites W2111486034 @default.
• W2080167811 cites W2115599934 @default.
• W2080167811 cites W2117412164 @default.
• W2080167811 cites W2130761693 @default.
• W2080167811 cites W2152252699 @default.
• W2080167811 cites W2153518488 @default.
• W2080167811 cites W2154935039 @default.
• W2080167811 cites W2159942182 @default.
• W2080167811 cites W2164136019 @default.
• W2080167811 cites W2170181331 @default.
• W2080167811 cites W2325509426 @default.
• W2080167811 cites W2336143221 @default.
• W2080167811 cites W2123692140 @default.
• W2080167811 doi "https://doi.org/10.1016/j.jep.2013.10.019" @default.
• W2080167811 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24189032" @default.
• W2080167811 hasPublicationYear "2014" @default.
• W2080167811 type Work @default.
• W2080167811 sameAs 2080167811 @default.
• W2080167811 citedByCount "38" @default.
• W2080167811 countsByYear W20801678112014 @default.
• W2080167811 countsByYear W20801678112015 @default.
• W2080167811 countsByYear W20801678112016 @default.
• W2080167811 countsByYear W20801678112017 @default.
• W2080167811 countsByYear W20801678112018 @default.
• W2080167811 countsByYear W20801678112019 @default.
• W2080167811 countsByYear W20801678112020 @default.
• W2080167811 countsByYear W20801678112021 @default.
• W2080167811 countsByYear W20801678112022 @default.
• W2080167811 countsByYear W20801678112023 @default.
• W2080167811 crossrefType "journal-article" @default.
• W2080167811 hasAuthorship W2080167811A5071178564 @default.
• W2080167811 hasAuthorship W2080167811A5073214484 @default.
• W2080167811 hasAuthorship W2080167811A5083946842 @default.
• W2080167811 hasConcept C109523444 @default.
• W2080167811 hasConcept C126322002 @default.
• W2080167811 hasConcept C134018914 @default.
• W2080167811 hasConcept C142724271 @default.
• W2080167811 hasConcept C146285616 @default.
• W2080167811 hasConcept C14858245 @default.
• W2080167811 hasConcept C164705383 @default.
• W2080167811 hasConcept C167734588 @default.
• W2080167811 hasConcept C179437574 @default.
• W2080167811 hasConcept C188947578 @default.
• W2080167811 hasConcept C201750760 @default.
• W2080167811 hasConcept C204787440 @default.
• W2080167811 hasConcept C2776332195 @default.
• W2080167811 hasConcept C2777025900 @default.
• W2080167811 hasConcept C2778271429 @default.
• W2080167811 hasConcept C2780152582 @default.
• W2080167811 hasConcept C2780394083 @default.
• W2080167811 hasConcept C28328180 @default.
• W2080167811 hasConcept C500558357 @default.
• W2080167811 hasConcept C541997718 @default.
• W2080167811 hasConcept C54355233 @default.
• W2080167811 hasConcept C71924100 @default.
• W2080167811 hasConcept C86803240 @default.
• W2080167811 hasConcept C98274493 @default.
• W2080167811 hasConceptScore W2080167811C109523444 @default.
• W2080167811 hasConceptScore W2080167811C126322002 @default.
• W2080167811 hasConceptScore W2080167811C134018914 @default.
• W2080167811 hasConceptScore W2080167811C142724271 @default.
• W2080167811 hasConceptScore W2080167811C146285616 @default.
• W2080167811 hasConceptScore W2080167811C14858245 @default.
• W2080167811 hasConceptScore W2080167811C164705383 @default.
• W2080167811 hasConceptScore W2080167811C167734588 @default.
• W2080167811 hasConceptScore W2080167811C179437574 @default.

• next