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- W2080188146 abstract "A new class of chemically and metabolically stable lipoxin analogs featuring a replacement of the tetraene unit of native LXA4 with a substituted benzo-fused ring system have been designed and studied. These molecules were readily synthesized via a convergent synthetic route involving iterative palladium-mediated cross-coupling, and exhibit enhanced chemical stability, as well as resistance to metabolic inactivation via eicosanoid oxido-reductase. These new LX analogs were evaluated in a model of acute inflammation and were shown to exhibit potent anti-inflammatory properties, significantly decreasing neutrophil infiltration in vivo. The most potent among these was compound 9 (o-[9,12]-benzo-15-epi-LXA4 methyl ester. Taken together, these findings help identify a new class of stable and easily prepared LX analogs that may serve as novel tools and as promising leads for new anti-inflammatory agents with improved therapeutic profile." @default.
- W2080188146 created "2016-06-24" @default.
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- W2080188146 date "2008-02-01" @default.
- W2080188146 modified "2023-10-14" @default.
- W2080188146 title "Design and synthesis of benzo-lipoxin A4 analogs with enhanced stability and potent anti-inflammatory properties" @default.
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- W2080188146 doi "https://doi.org/10.1016/j.bmcl.2008.01.013" @default.
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