FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2080451201> ?p ?o ?g. }

• W2080451201 endingPage "41" @default.
• W2080451201 startingPage "34" @default.
• W2080451201 abstract "Previously, we demonstrated that lipocalin-type prostaglandin D(2) synthase (L-PGDS) knockout mice become glucose intolerant and display signs of diabetic nephropathy and accelerated atherosclerosis. In the current study we sought to explain the link between L-PGDS and glucose tolerance. Using the insulin-sensitive rat skeletal muscle cell line, L6, we showed that L-PGDS could stimulate glucose transport approximately 2-fold as well as enhance insulin-stimulated glucose transport, as measured by 2-deoxy-[(3)H]-glucose uptake. The increased glucose transport was not attributed to increased GLUT4 production but rather the stimulation of GLUT4 translocation to the plasma membrane, a phenomenon that was lost when cells were cultured under hyperglycemic (20 mM) conditions or pretreated with wortmannin. There was however, an increase in GLUT1 expression as well as a 3-fold increase in hexokinase III expression, which was increased to nearly 5-fold in the presence of insulin, in response to L-PGDS at 20 mM glucose. In addition, adipocytes isolated from L-PGDS knockout mice were significantly less sensitive to insulin-stimulated glucose transport than wild-type. We conclude that L-PGDS, via production of prostaglandin D(2), is an important mediator of muscle and adipose glucose transport which is modulated by glycemic conditions and plays a significant role in the glucose intolerance associated with type 2 diabetes." @default.
• W2080451201 created "2016-06-24" @default.
• W2080451201 creator A5009748611 @default.
• W2080451201 creator A5060686855 @default.
• W2080451201 creator A5085667878 @default.
• W2080451201 date "2008-12-01" @default.
• W2080451201 modified "2023-09-26" @default.
• W2080451201 title "Lipocalin-type prostaglandin D2 synthase stimulates glucose transport via enhanced GLUT4 translocation" @default.
• W2080451201 cites W1511203783 @default.
• W2080451201 cites W1579749290 @default.
• W2080451201 cites W1963515401 @default.
• W2080451201 cites W1963812525 @default.
• W2080451201 cites W1968990080 @default.
• W2080451201 cites W1971551222 @default.
• W2080451201 cites W1982252005 @default.
• W2080451201 cites W1986400512 @default.
• W2080451201 cites W1988416606 @default.
• W2080451201 cites W1992409174 @default.
• W2080451201 cites W1993603249 @default.
• W2080451201 cites W1994188231 @default.
• W2080451201 cites W1998702348 @default.
• W2080451201 cites W2002871502 @default.
• W2080451201 cites W2008746494 @default.
• W2080451201 cites W2015704112 @default.
• W2080451201 cites W2018430304 @default.
• W2080451201 cites W2029332640 @default.
• W2080451201 cites W2041055520 @default.
• W2080451201 cites W2048596983 @default.
• W2080451201 cites W2061914106 @default.
• W2080451201 cites W2081225918 @default.
• W2080451201 cites W2088282211 @default.
• W2080451201 cites W2088531922 @default.
• W2080451201 cites W2088653441 @default.
• W2080451201 cites W2096182335 @default.
• W2080451201 cites W2097409273 @default.
• W2080451201 cites W2111141308 @default.
• W2080451201 cites W2112665865 @default.
• W2080451201 cites W2113506184 @default.
• W2080451201 cites W2115800040 @default.
• W2080451201 cites W2124393620 @default.
• W2080451201 cites W2127014382 @default.
• W2080451201 cites W2127395282 @default.
• W2080451201 cites W2146885685 @default.
• W2080451201 cites W2154004234 @default.
• W2080451201 cites W2323327238 @default.
• W2080451201 cites W4232534952 @default.
• W2080451201 cites W4254877841 @default.
• W2080451201 doi "https://doi.org/10.1016/j.prostaglandins.2008.06.001" @default.
• W2080451201 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18619553" @default.
• W2080451201 hasPublicationYear "2008" @default.
• W2080451201 type Work @default.
• W2080451201 sameAs 2080451201 @default.
• W2080451201 citedByCount "19" @default.
• W2080451201 countsByYear W20804512012012 @default.
• W2080451201 countsByYear W20804512012014 @default.
• W2080451201 countsByYear W20804512012015 @default.
• W2080451201 countsByYear W20804512012018 @default.
• W2080451201 countsByYear W20804512012020 @default.
• W2080451201 countsByYear W20804512012021 @default.
• W2080451201 countsByYear W20804512012022 @default.
• W2080451201 crossrefType "journal-article" @default.
• W2080451201 hasAuthorship W2080451201A5009748611 @default.
• W2080451201 hasAuthorship W2080451201A5060686855 @default.
• W2080451201 hasAuthorship W2080451201A5085667878 @default.
• W2080451201 hasConcept C126322002 @default.
• W2080451201 hasConcept C134018914 @default.
• W2080451201 hasConcept C161573976 @default.
• W2080451201 hasConcept C185592680 @default.
• W2080451201 hasConcept C2776188179 @default.
• W2080451201 hasConcept C2777180221 @default.
• W2080451201 hasConcept C2777866211 @default.
• W2080451201 hasConcept C2777952866 @default.
• W2080451201 hasConcept C2779306644 @default.
• W2080451201 hasConcept C555293320 @default.
• W2080451201 hasConcept C71924100 @default.
• W2080451201 hasConcept C86803240 @default.
• W2080451201 hasConceptScore W2080451201C126322002 @default.
• W2080451201 hasConceptScore W2080451201C134018914 @default.
• W2080451201 hasConceptScore W2080451201C161573976 @default.
• W2080451201 hasConceptScore W2080451201C185592680 @default.
• W2080451201 hasConceptScore W2080451201C2776188179 @default.
• W2080451201 hasConceptScore W2080451201C2777180221 @default.
• W2080451201 hasConceptScore W2080451201C2777866211 @default.
• W2080451201 hasConceptScore W2080451201C2777952866 @default.
• W2080451201 hasConceptScore W2080451201C2779306644 @default.
• W2080451201 hasConceptScore W2080451201C555293320 @default.
• W2080451201 hasConceptScore W2080451201C71924100 @default.
• W2080451201 hasConceptScore W2080451201C86803240 @default.
• W2080451201 hasIssue "1-4" @default.
• W2080451201 hasLocation W20804512011 @default.
• W2080451201 hasLocation W20804512012 @default.
• W2080451201 hasOpenAccess W2080451201 @default.
• W2080451201 hasPrimaryLocation W20804512011 @default.
• W2080451201 hasRelatedWork W1988699731 @default.
• W2080451201 hasRelatedWork W1990014351 @default.
• W2080451201 hasRelatedWork W2060118222 @default.
• W2080451201 hasRelatedWork W2087127797 @default.
• W2080451201 hasRelatedWork W2114435268 @default.

• next