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• W2080640993 endingPage "526" @default.
• W2080640993 startingPage "514" @default.
• W2080640993 abstract "Profound alterations in the microsomal fatty acyl-CoA desaturase activities and cyclic AMP production of a unicellular eukaryote, Tetrahymena pyriformis NT-1, originally grown in the glucose-deficient medium, were observed, following the administration of glucose or β-adrenergic agonists such as epinephrine and isoproterenol. There was a great increase of stearoyl-CoA (Δ 8 desaturase activity coincident with a 2-fold decrease of oleoyl-CoA (Δ 12 ) desaturase activity over the first 2 h after administration of these compounds. During this period of time, it was found that the production in vivo of labeled oleic acid from [ 14 C]acetic or [ 3 H]palmitic acid increases 2-fold and the formation in vivo of each labeled linoleic and γ-linolenic acids drastically decreases. Glucose or β-adrenergic agonists caused an increase of stearoyl-CoA-stimulated reoxidation rate of NADH-reduced cytochrome b 5 but depressed oleoyl-CoA-stimulated reoxidation rate of b 5 , indicating that both desaturase activities are controlled by the respective terminal components of the desaturase system. A significant and reproducible increase of adenylate cyclase activity and a slight decrease of cyclic AMP phosphodiesterase activity were observed to occur within the first 2 h after the addition of these compounds, when cyclic AMP content in Tetrahymena cell rose by 3–4-fold. Propranolol, a β-adrenergic blocker, abolished the effects of glucose or β-adrenergic agonists on the activities of fatty acyl-CoA desaturases and the terminal components as well as cyclic AMP production of cells. These results suggest that glucose and β-adrenergic agonists may modulate the microsomal fatty acyl-CoA desaturase system in Tetrahymena by acting through the increase of intracellular cyclic AMP content." @default.
• W2080640993 created "2016-06-24" @default.
• W2080640993 creator A5049786044 @default.
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• W2080640993 date "1985-07-01" @default.
• W2080640993 modified "2023-10-13" @default.
• W2080640993 title "A possible cyclic AMP-mediated regulation of microsomal fatty acyl-CoA desaturation system in Tetrahymena microsomes" @default.
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• W2080640993 doi "https://doi.org/10.1016/0005-2760(85)90120-1" @default.
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