Matches in SemOpenAlex for { <https://semopenalex.org/work/W2080839500> ?p ?o ?g. }
Showing items 1 to 92 of
92
with 100 items per page.
- W2080839500 endingPage "403" @default.
- W2080839500 startingPage "397" @default.
- W2080839500 abstract "Kupffer cells are exposed directly to a number of factors in the portal circulation that can modify or regulate their responses to septic stimuli. The gut represents a potential source of a number of these factors including endotoxin, lymphokines, and prostaglandins. We examined Kupffer cells from germfree rats and germfree rats exposed to endotoxin or bacteria via their GI tracts to determine the importance of the intestinal flora in maintaining or modulating Kupffer cell responses. Kupffer cells from germfree animals were reduced in numbers and failed to respond to LPS in Kupffer cell: hepatocyte coculture. When germfree rats were exposed to bacterial endotoxin or bacteria via the gastrointestinal tract their Kupffer cells increased in numbers to normal and the cells responded to LPS in culture. Intestinal overgrowth with Escherichia coli for 2 days activated the Kupffer cells and significantly increased Kupffer cell sensitivity to LPS. These data suggest that the environment of the gastrointestinal tract is important for normal Kupffer cell responses and that intestinal bacterial overgrowth can modify Kupffer cell responses to septic stimuli." @default.
- W2080839500 created "2016-06-24" @default.
- W2080839500 creator A5005895944 @default.
- W2080839500 creator A5021897609 @default.
- W2080839500 creator A5022646943 @default.
- W2080839500 creator A5062076820 @default.
- W2080839500 creator A5065279648 @default.
- W2080839500 date "1988-04-01" @default.
- W2080839500 modified "2023-10-16" @default.
- W2080839500 title "The role of intestinal flora on the interactions between nonparenchymal cells and hepatocytes in coculture" @default.
- W2080839500 cites W1490154674 @default.
- W2080839500 cites W1587144004 @default.
- W2080839500 cites W1772814577 @default.
- W2080839500 cites W1846097974 @default.
- W2080839500 cites W1899898570 @default.
- W2080839500 cites W1905885715 @default.
- W2080839500 cites W1907143548 @default.
- W2080839500 cites W1940134409 @default.
- W2080839500 cites W1952384394 @default.
- W2080839500 cites W1953477450 @default.
- W2080839500 cites W1958717604 @default.
- W2080839500 cites W1990216135 @default.
- W2080839500 cites W2038444011 @default.
- W2080839500 cites W2045040849 @default.
- W2080839500 cites W2050490859 @default.
- W2080839500 cites W2053277538 @default.
- W2080839500 cites W2073180142 @default.
- W2080839500 cites W2150501935 @default.
- W2080839500 cites W2159069239 @default.
- W2080839500 doi "https://doi.org/10.1016/0022-4804(88)90182-5" @default.
- W2080839500 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3283454" @default.
- W2080839500 hasPublicationYear "1988" @default.
- W2080839500 type Work @default.
- W2080839500 sameAs 2080839500 @default.
- W2080839500 citedByCount "27" @default.
- W2080839500 countsByYear W20808395002013 @default.
- W2080839500 crossrefType "journal-article" @default.
- W2080839500 hasAuthorship W2080839500A5005895944 @default.
- W2080839500 hasAuthorship W2080839500A5021897609 @default.
- W2080839500 hasAuthorship W2080839500A5022646943 @default.
- W2080839500 hasAuthorship W2080839500A5062076820 @default.
- W2080839500 hasAuthorship W2080839500A5065279648 @default.
- W2080839500 hasConcept C134018914 @default.
- W2080839500 hasConcept C1491633281 @default.
- W2080839500 hasConcept C195521686 @default.
- W2080839500 hasConcept C202751555 @default.
- W2080839500 hasConcept C203014093 @default.
- W2080839500 hasConcept C2776200302 @default.
- W2080839500 hasConcept C2778904781 @default.
- W2080839500 hasConcept C2780512811 @default.
- W2080839500 hasConcept C2908801736 @default.
- W2080839500 hasConcept C49382859 @default.
- W2080839500 hasConcept C55493867 @default.
- W2080839500 hasConcept C86803240 @default.
- W2080839500 hasConcept C8891405 @default.
- W2080839500 hasConcept C89423630 @default.
- W2080839500 hasConceptScore W2080839500C134018914 @default.
- W2080839500 hasConceptScore W2080839500C1491633281 @default.
- W2080839500 hasConceptScore W2080839500C195521686 @default.
- W2080839500 hasConceptScore W2080839500C202751555 @default.
- W2080839500 hasConceptScore W2080839500C203014093 @default.
- W2080839500 hasConceptScore W2080839500C2776200302 @default.
- W2080839500 hasConceptScore W2080839500C2778904781 @default.
- W2080839500 hasConceptScore W2080839500C2780512811 @default.
- W2080839500 hasConceptScore W2080839500C2908801736 @default.
- W2080839500 hasConceptScore W2080839500C49382859 @default.
- W2080839500 hasConceptScore W2080839500C55493867 @default.
- W2080839500 hasConceptScore W2080839500C86803240 @default.
- W2080839500 hasConceptScore W2080839500C8891405 @default.
- W2080839500 hasConceptScore W2080839500C89423630 @default.
- W2080839500 hasIssue "4" @default.
- W2080839500 hasLocation W20808395001 @default.
- W2080839500 hasLocation W20808395002 @default.
- W2080839500 hasOpenAccess W2080839500 @default.
- W2080839500 hasPrimaryLocation W20808395001 @default.
- W2080839500 hasRelatedWork W1707136513 @default.
- W2080839500 hasRelatedWork W1980336214 @default.
- W2080839500 hasRelatedWork W2014717081 @default.
- W2080839500 hasRelatedWork W2065412367 @default.
- W2080839500 hasRelatedWork W2379169761 @default.
- W2080839500 hasRelatedWork W2414097621 @default.
- W2080839500 hasRelatedWork W2479109478 @default.
- W2080839500 hasRelatedWork W3040080613 @default.
- W2080839500 hasRelatedWork W3149564256 @default.
- W2080839500 hasRelatedWork W591029602 @default.
- W2080839500 hasVolume "44" @default.
- W2080839500 isParatext "false" @default.
- W2080839500 isRetracted "false" @default.
- W2080839500 magId "2080839500" @default.
- W2080839500 workType "article" @default.