Matches in SemOpenAlex for { <https://semopenalex.org/work/W2081027077> ?p ?o ?g. }
- W2081027077 endingPage "2381" @default.
- W2081027077 startingPage "2369" @default.
- W2081027077 abstract "Despite its importance as the leading cause of vascular dementia, the primary pathogenic mechanisms in subcortical ischemic vascular dementia (SIVD) have remained elusive. Because of the lack of approved therapeutic agents for SIVD, there is a pressing need to identify novel therapeutic targets. Comparative lipidomic analyses of SIVD and mixed dementia (i.e., SIVD and Alzheimer's disease, MixD) may also confer new insights pertaining to the possible interaction between neurodegenerative and vascular mechanisms in the pathogenesis of dementia. Liquid chromatography coupled to mass spectrometry was used to comprehensively analyze the lipidomes of white and gray matter from the temporal cortex of nondemented controls, SIVD, and MixD subjects. Detailed molecular profiles highlighted the pathologic relevance of gray matter sphingolipid fatty acyl chain heterogeneity in dementia. In addition, the levels of sulfatides and lysobisphosphatidic acids were progressively increased in the temporal cortex gray matter from control to SIVD to MixD. White matter phospholipid profiles indicated possible adaptive mechanisms (i.e., increased unsaturation) to chronic ischemia in SIVD and elevated membrane degradation in MixD." @default.
- W2081027077 created "2016-06-24" @default.
- W2081027077 creator A5009097397 @default.
- W2081027077 creator A5012308909 @default.
- W2081027077 creator A5022789521 @default.
- W2081027077 creator A5032261625 @default.
- W2081027077 creator A5041966023 @default.
- W2081027077 creator A5053891607 @default.
- W2081027077 creator A5076808018 @default.
- W2081027077 creator A5090674310 @default.
- W2081027077 date "2014-10-01" @default.
- W2081027077 modified "2023-10-18" @default.
- W2081027077 title "The brain lipidomes of subcortical ischemic vascular dementia and mixed dementia" @default.
- W2081027077 cites W1560871346 @default.
- W2081027077 cites W1594975246 @default.
- W2081027077 cites W1605199145 @default.
- W2081027077 cites W1926169850 @default.
- W2081027077 cites W1966577064 @default.
- W2081027077 cites W1970028556 @default.
- W2081027077 cites W1973215139 @default.
- W2081027077 cites W1974823287 @default.
- W2081027077 cites W1977570151 @default.
- W2081027077 cites W1984542598 @default.
- W2081027077 cites W1995954863 @default.
- W2081027077 cites W1996149510 @default.
- W2081027077 cites W2006276754 @default.
- W2081027077 cites W2013312860 @default.
- W2081027077 cites W2024211256 @default.
- W2081027077 cites W2024289001 @default.
- W2081027077 cites W2031470355 @default.
- W2081027077 cites W2034298815 @default.
- W2081027077 cites W2034385545 @default.
- W2081027077 cites W2036204652 @default.
- W2081027077 cites W2038003677 @default.
- W2081027077 cites W2042902316 @default.
- W2081027077 cites W2048943469 @default.
- W2081027077 cites W2052742260 @default.
- W2081027077 cites W2053143967 @default.
- W2081027077 cites W2055991100 @default.
- W2081027077 cites W2061773768 @default.
- W2081027077 cites W2067752412 @default.
- W2081027077 cites W2068633603 @default.
- W2081027077 cites W2070054259 @default.
- W2081027077 cites W2076649565 @default.
- W2081027077 cites W2078675004 @default.
- W2081027077 cites W2088721660 @default.
- W2081027077 cites W2090014162 @default.
- W2081027077 cites W2103141455 @default.
- W2081027077 cites W2104901197 @default.
- W2081027077 cites W2120683729 @default.
- W2081027077 cites W2123805624 @default.
- W2081027077 cites W2131633378 @default.
- W2081027077 cites W2135498730 @default.
- W2081027077 cites W2143226458 @default.
- W2081027077 cites W2146729934 @default.
- W2081027077 cites W2155893481 @default.
- W2081027077 cites W2157110881 @default.
- W2081027077 cites W2165316494 @default.
- W2081027077 cites W2168330997 @default.
- W2081027077 cites W2168334242 @default.
- W2081027077 cites W2172053191 @default.
- W2081027077 cites W2189978747 @default.
- W2081027077 cites W4210993281 @default.
- W2081027077 cites W4296588155 @default.
- W2081027077 doi "https://doi.org/10.1016/j.neurobiolaging.2014.02.025" @default.
- W2081027077 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4099521" @default.
- W2081027077 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24684787" @default.
- W2081027077 hasPublicationYear "2014" @default.
- W2081027077 type Work @default.
- W2081027077 sameAs 2081027077 @default.
- W2081027077 citedByCount "75" @default.
- W2081027077 countsByYear W20810270772014 @default.
- W2081027077 countsByYear W20810270772015 @default.
- W2081027077 countsByYear W20810270772016 @default.
- W2081027077 countsByYear W20810270772017 @default.
- W2081027077 countsByYear W20810270772018 @default.
- W2081027077 countsByYear W20810270772019 @default.
- W2081027077 countsByYear W20810270772020 @default.
- W2081027077 countsByYear W20810270772021 @default.
- W2081027077 countsByYear W20810270772022 @default.
- W2081027077 countsByYear W20810270772023 @default.
- W2081027077 crossrefType "journal-article" @default.
- W2081027077 hasAuthorship W2081027077A5009097397 @default.
- W2081027077 hasAuthorship W2081027077A5012308909 @default.
- W2081027077 hasAuthorship W2081027077A5022789521 @default.
- W2081027077 hasAuthorship W2081027077A5032261625 @default.
- W2081027077 hasAuthorship W2081027077A5041966023 @default.
- W2081027077 hasAuthorship W2081027077A5053891607 @default.
- W2081027077 hasAuthorship W2081027077A5076808018 @default.
- W2081027077 hasAuthorship W2081027077A5090674310 @default.
- W2081027077 hasBestOaLocation W20810270771 @default.
- W2081027077 hasConcept C126322002 @default.
- W2081027077 hasConcept C126838900 @default.
- W2081027077 hasConcept C143409427 @default.
- W2081027077 hasConcept C15744967 @default.
- W2081027077 hasConcept C169760540 @default.
- W2081027077 hasConcept C2777952318 @default.
- W2081027077 hasConcept C2779134260 @default.