FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2082055400> ?p ?o ?g. }

• W2082055400 endingPage "544" @default.
• W2082055400 startingPage "531" @default.
• W2082055400 abstract "Peripherin, a type III intermediate filament (IF) protein, upregulated by injury and inflammatory cytokines, is a component of IF inclusion bodies associated with degenerating motor neurons in sporadic amyotrophic lateral sclerosis (ALS). We report here that sustained overexpression of wild-type peripherin in mice provokes massive and selective degeneration of motor axons during aging. Remarkably, the onset of peripherin-mediated disease was precipitated by a deficiency of neurofilament light (NF-L) protein, a phenomenon associated with sporadic ALS. In NF-L null mice, the overexpression of peripherin led to early- onset formation of IF inclusions and to the selective death of spinal motor neurons at 6 mo of age. We also report the formation of similar peripherin inclusions in presymptomatic transgenic mice expressing a mutant form of superoxide dismutase linked to ALS. Taken together, these results suggest that IF inclusions containing peripherin may play a contributory role in motor neuron disease." @default.
• W2082055400 created "2016-06-24" @default.
• W2082055400 creator A5002357596 @default.
• W2082055400 creator A5058693559 @default.
• W2082055400 creator A5091664460 @default.
• W2082055400 date "1999-11-01" @default.
• W2082055400 modified "2023-09-25" @default.
• W2082055400 title "Late Onset Death of Motor Neurons in Mice Overexpressing Wild-Type Peripherin" @default.
• W2082055400 cites W127771585 @default.
• W2082055400 cites W1573139030 @default.
• W2082055400 cites W1592357554 @default.
• W2082055400 cites W1592463385 @default.
• W2082055400 cites W1637939020 @default.
• W2082055400 cites W1836362700 @default.
• W2082055400 cites W1960315548 @default.
• W2082055400 cites W1969530642 @default.
• W2082055400 cites W1986234504 @default.
• W2082055400 cites W1989326240 @default.
• W2082055400 cites W1998238515 @default.
• W2082055400 cites W2003284733 @default.
• W2082055400 cites W2008563656 @default.
• W2082055400 cites W2009837389 @default.
• W2082055400 cites W2011575330 @default.
• W2082055400 cites W2012851706 @default.
• W2082055400 cites W2013135033 @default.
• W2082055400 cites W2013271691 @default.
• W2082055400 cites W2014669590 @default.
• W2082055400 cites W2017178450 @default.
• W2082055400 cites W2018726628 @default.
• W2082055400 cites W2022367303 @default.
• W2082055400 cites W2026282644 @default.
• W2082055400 cites W2036377561 @default.
• W2082055400 cites W2037024974 @default.
• W2082055400 cites W2037174641 @default.
• W2082055400 cites W2038010620 @default.
• W2082055400 cites W2040004819 @default.
• W2082055400 cites W2040621074 @default.
• W2082055400 cites W2048650123 @default.
• W2082055400 cites W2049395473 @default.
• W2082055400 cites W2049928253 @default.
• W2082055400 cites W2051672511 @default.
• W2082055400 cites W2053659562 @default.
• W2082055400 cites W2058599222 @default.
• W2082055400 cites W2070243481 @default.
• W2082055400 cites W2071434138 @default.
• W2082055400 cites W2073614451 @default.
• W2082055400 cites W2076389168 @default.
• W2082055400 cites W2079474271 @default.
• W2082055400 cites W2089750155 @default.
• W2082055400 cites W2090095487 @default.
• W2082055400 cites W2091821388 @default.
• W2082055400 cites W2092805188 @default.
• W2082055400 cites W2096386031 @default.
• W2082055400 cites W2103154621 @default.
• W2082055400 cites W2106526071 @default.
• W2082055400 cites W2107768418 @default.
• W2082055400 cites W2119310960 @default.
• W2082055400 cites W2121726351 @default.
• W2082055400 cites W2133400638 @default.
• W2082055400 cites W2140306710 @default.
• W2082055400 cites W2145605085 @default.
• W2082055400 cites W2167166322 @default.
• W2082055400 cites W2402895706 @default.
• W2082055400 cites W2416666937 @default.
• W2082055400 cites W2473386983 @default.
• W2082055400 cites W4238285667 @default.
• W2082055400 cites W4252368281 @default.
• W2082055400 cites W4299517802 @default.
• W2082055400 cites W2462671818 @default.
• W2082055400 doi "https://doi.org/10.1083/jcb.147.3.531" @default.
• W2082055400 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2151189" @default.
• W2082055400 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15132161" @default.
• W2082055400 hasPublicationYear "1999" @default.
• W2082055400 type Work @default.
• W2082055400 sameAs 2082055400 @default.
• W2082055400 citedByCount "233" @default.
• W2082055400 countsByYear W20820554002012 @default.
• W2082055400 countsByYear W20820554002013 @default.
• W2082055400 countsByYear W20820554002014 @default.
• W2082055400 countsByYear W20820554002015 @default.
• W2082055400 countsByYear W20820554002016 @default.
• W2082055400 countsByYear W20820554002017 @default.
• W2082055400 countsByYear W20820554002018 @default.
• W2082055400 countsByYear W20820554002019 @default.
• W2082055400 countsByYear W20820554002020 @default.
• W2082055400 countsByYear W20820554002021 @default.
• W2082055400 countsByYear W20820554002022 @default.
• W2082055400 countsByYear W20820554002023 @default.
• W2082055400 crossrefType "journal-article" @default.
• W2082055400 hasAuthorship W2082055400A5002357596 @default.
• W2082055400 hasAuthorship W2082055400A5058693559 @default.
• W2082055400 hasAuthorship W2082055400A5091664460 @default.
• W2082055400 hasBestOaLocation W20820554001 @default.
• W2082055400 hasConcept C102230213 @default.
• W2082055400 hasConcept C104317684 @default.
• W2082055400 hasConcept C141035611 @default.
• W2082055400 hasConcept C142669718 @default.
• W2082055400 hasConcept C142724271 @default.

• next