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• W2085887280 abstract "Significance The emergence of Middle East respiratory syndrome coronavirus (MERS-CoV), a deadly human coronavirus, has triggered considerable interest in the biomedical community. Similar to other enveloped viruses, coronaviruses access host cells by membrane fusion, a process mediated by specific fusion or “spike” proteins on the virion, often activated by cellular proteases. We have identified unique features of the MERS-CoV spike (S) protein cleavage activation. Our findings suggest that S can be activated by furin, a broadly expressed protease, by a two-step cleavage mechanism, occurring at distinct sites, with cleavage events temporally separated. Such furin-mediated activation is unusual in that it occurs in part during virus entry. Our findings may explain the polytropic nature, pathogenicity, and life cycle of this zoonotic coronavirus." @default.
• W2085887280 created "2016-06-24" @default.
• W2085887280 creator A5006583074 @default.
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• W2085887280 date "2014-10-06" @default.
• W2085887280 modified "2023-10-05" @default.
• W2085887280 title "Host cell entry of Middle East respiratory syndrome coronavirus after two-step, furin-mediated activation of the spike protein" @default.
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• W2085887280 doi "https://doi.org/10.1073/pnas.1407087111" @default.
• W2085887280 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4210292" @default.
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• W2085887280 hasPublicationYear "2014" @default.
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