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• W2085984995 abstract "This study aimed to elucidate the influence of the route of administration of exogenous lipid emulsions (Intralipid, Kabivitrum, Stockholm, Sweden) on bacterial translocation and immune suppression in a shocked and resuscitated rat trauma model. Sixty-five male Long-Evans rats were divided into three groups, viz. controls, enterally fed and intravenously fed rats. Experimental rats were traumatized by laparotomy with manipulation of bowel, creation of subcutaneous and femoral catheterization tunnels, and shocked by controlled exsanguination for twenty minutes before resuscitation by reinfusion of shed blood. While the experimental groups received 20% Intralipid infusions, post-operatively, the control group received standard rat chow and water ad libitum. Lipid infusions were administered at a rate of 70ml/kg/day, either intravenously via a central line, or enterally, via a gastro-jejunostomy line. Twenty four hours later, at sacrifice, bacterial translocation rates into mesenteric lymph nodes (MLN), blood and organs were studied. In addition, mitogen-stimulated lymphocyte transformation rates (LTR), as an index of immune suppression were assessed. The greatest rates of translocation were to the mesenteric lymph nodes, with only insignificant translocation to peripheral blood, liver and spleen occurring. Both experimental groups showed significantly more translocation than the uninjured controls (P<0.05), and there was significantly more translocation seen in the enteral than in the parenteral feeding groups (P<0.05). In the LTR studies, it could clearly be shown that while suppression occurred in the control group, there was significantly less suppression in the intravenously fed animals (P<0.05)." @default.
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• W2085984995 date "1994-03-01" @default.
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• W2085984995 title "The effect of intravenous versus enteral infusions of lipid emulsions (Intralipid) on bacterial translocation and immune function in a rat model of resuscitated haemorrhagic shock and trauma" @default.
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• W2085984995 doi "https://doi.org/10.1016/s0271-5317(05)80180-0" @default.
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