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• W2086836368 abstract "The changes in glomerular extracellular matrices components in diabetic nephropathy were investigated. Indirect immunofluorescence staining, using polyclonal antibodies to heparan sulfate proteoglycan (HS-PG), laminin, type IV collagen, and fibronectin was carried out on renal specimens obtained by needle biopsy. Immunofluorescence intensity and distribution were observed. HS-PG and laminin decreased in the capillary walls; on the other hand, type IV collagen and fibronectin tended to increase in the mesangial area. HS-PG and laminin decreased in inverse proportion to sclerosis grades and proteinuria. These changes seemed to play an important role in progression of diabetic glomerulosclerosis." @default.
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• W2086836368 date "1991-04-01" @default.
• W2086836368 modified "2023-09-26" @default.
• W2086836368 title "Changes in glomerular extracellular matrices components in diabetic nephropathy" @default.
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• W2086836368 doi "https://doi.org/10.1016/0891-6632(91)90068-z" @default.
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