Matches in SemOpenAlex for { <https://semopenalex.org/work/W2087282502> ?p ?o ?g. }
- W2087282502 endingPage "317" @default.
- W2087282502 startingPage "311" @default.
- W2087282502 abstract "Abstract: Depressive disorder (DD) is characterised by disturbances in blood melatonin concentration. It is well known that melatonin is involved in the control of circadian rhythms, sleep included. The use of melatonin and its analogues has been found to be effective in depression therapy. Melatonin synthesis is a multistage process, where the last stage is catalysed by acetylserotonin methyltransferase (ASMT), the reported rate‐limiting melatonin synthesis enzyme. Taking into account the significance of genetic factors in depression development, the gene for ASMT may become an interesting focus for studies in patients with recurrent DD. The goal of the study was to evaluate two single‐nucleotide polymorphisms (SNPs) (rs4446909; rs5989681) of the ASMT gene, as well as mRNA expression for ASMT in recurrent DD‐affected patients. We genotyped two polymorphisms in a group of 181 recurrent DD patients and in 149 control subjects. The study was performed using the polymerase chain reaction/restriction fragment length polymorphism method. The distribution of genotypes in both studied SNPs in the ASMT gene differed significantly between DD and healthy subjects. The presence of AA genotype of rs4446909 polymorphism and of GG genotype of rs5989681 polymorphism was associated with lower risk for having recurrent DD. In turn, patients with depression were characterised by reduced mRNA expression for ASMT. In addition, ASMT transcript level in both recurrent DD patients and in healthy subjects depended significantly on genotype distributions in both polymorphisms. In conclusion, our results suggest the ASMT gene as a susceptibility gene for recurrent DD." @default.
- W2087282502 created "2016-06-24" @default.
- W2087282502 creator A5002120627 @default.
- W2087282502 creator A5010965592 @default.
- W2087282502 creator A5026386207 @default.
- W2087282502 creator A5035698230 @default.
- W2087282502 creator A5043160837 @default.
- W2087282502 creator A5048119650 @default.
- W2087282502 creator A5063736852 @default.
- W2087282502 creator A5074145474 @default.
- W2087282502 date "2010-04-08" @default.
- W2087282502 modified "2023-10-16" @default.
- W2087282502 title "Single-nucleotide polymorphisms and mRNA expression for melatonin synthesis rate-limiting enzyme in recurrent depressive disorder" @default.
- W2087282502 cites W1562048214 @default.
- W2087282502 cites W1964130521 @default.
- W2087282502 cites W1966006827 @default.
- W2087282502 cites W1968000210 @default.
- W2087282502 cites W1968000956 @default.
- W2087282502 cites W1974564805 @default.
- W2087282502 cites W1974618278 @default.
- W2087282502 cites W1976675821 @default.
- W2087282502 cites W1978384715 @default.
- W2087282502 cites W1981026457 @default.
- W2087282502 cites W1982054620 @default.
- W2087282502 cites W1983241347 @default.
- W2087282502 cites W1988934115 @default.
- W2087282502 cites W1994597265 @default.
- W2087282502 cites W1998172466 @default.
- W2087282502 cites W2002206403 @default.
- W2087282502 cites W2003532302 @default.
- W2087282502 cites W2004607162 @default.
- W2087282502 cites W2004790444 @default.
- W2087282502 cites W2007674526 @default.
- W2087282502 cites W2011925229 @default.
- W2087282502 cites W2013891609 @default.
- W2087282502 cites W2025558700 @default.
- W2087282502 cites W2029586222 @default.
- W2087282502 cites W2030120215 @default.
- W2087282502 cites W2035309358 @default.
- W2087282502 cites W2039218955 @default.
- W2087282502 cites W2040381274 @default.
- W2087282502 cites W2041347130 @default.
- W2087282502 cites W2044934033 @default.
- W2087282502 cites W2048106194 @default.
- W2087282502 cites W2048348570 @default.
- W2087282502 cites W2057552891 @default.
- W2087282502 cites W2059735897 @default.
- W2087282502 cites W2060345189 @default.
- W2087282502 cites W2062447292 @default.
- W2087282502 cites W2064452700 @default.
- W2087282502 cites W2069251158 @default.
- W2087282502 cites W2075108722 @default.
- W2087282502 cites W2077733133 @default.
- W2087282502 cites W2078114029 @default.
- W2087282502 cites W2089417699 @default.
- W2087282502 cites W2096579248 @default.
- W2087282502 cites W2104247936 @default.
- W2087282502 cites W2110043186 @default.
- W2087282502 cites W2122352230 @default.
- W2087282502 cites W2123239432 @default.
- W2087282502 cites W2125475249 @default.
- W2087282502 cites W2135564221 @default.
- W2087282502 cites W2145600720 @default.
- W2087282502 cites W2158764823 @default.
- W2087282502 cites W2190787541 @default.
- W2087282502 cites W2409513133 @default.
- W2087282502 cites W250671454 @default.
- W2087282502 cites W4210424198 @default.
- W2087282502 cites W4229807268 @default.
- W2087282502 cites W4294216491 @default.
- W2087282502 doi "https://doi.org/10.1111/j.1600-079x.2010.00754.x" @default.
- W2087282502 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20433639" @default.
- W2087282502 hasPublicationYear "2010" @default.
- W2087282502 type Work @default.
- W2087282502 sameAs 2087282502 @default.
- W2087282502 citedByCount "60" @default.
- W2087282502 countsByYear W20872825022012 @default.
- W2087282502 countsByYear W20872825022013 @default.
- W2087282502 countsByYear W20872825022014 @default.
- W2087282502 countsByYear W20872825022015 @default.
- W2087282502 countsByYear W20872825022016 @default.
- W2087282502 countsByYear W20872825022017 @default.
- W2087282502 countsByYear W20872825022018 @default.
- W2087282502 countsByYear W20872825022019 @default.
- W2087282502 countsByYear W20872825022020 @default.
- W2087282502 countsByYear W20872825022021 @default.
- W2087282502 countsByYear W20872825022022 @default.
- W2087282502 crossrefType "journal-article" @default.
- W2087282502 hasAuthorship W2087282502A5002120627 @default.
- W2087282502 hasAuthorship W2087282502A5010965592 @default.
- W2087282502 hasAuthorship W2087282502A5026386207 @default.
- W2087282502 hasAuthorship W2087282502A5035698230 @default.
- W2087282502 hasAuthorship W2087282502A5043160837 @default.
- W2087282502 hasAuthorship W2087282502A5048119650 @default.
- W2087282502 hasAuthorship W2087282502A5063736852 @default.
- W2087282502 hasAuthorship W2087282502A5074145474 @default.
- W2087282502 hasConcept C104317684 @default.
- W2087282502 hasConcept C126322002 @default.