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- W2087309148 abstract "Cysteine inhibited the in vitro covalent binding of [14C] chloroform, (CHCl3), to microsomal protein and concomitantly trapped a reactive metabolite, presumably phosgene (COCl2), as 2-oxothiazolidine-4-carboxylic acid. When the incubation was conducted in an atmosphere of [18O] O2, the trapped COCl2 contained [18O]. These findings suggest that the CH bond of CHCl3 is oxidized by a cytochrome P-450 monooxygenase to produce trichloromethanol, which spontaneously dehydrochlorinates to yield the toxic agent phosgene." @default.
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- W2087309148 date "1977-12-01" @default.
- W2087309148 modified "2023-10-10" @default.
- W2087309148 title "Phosgene: A metabolite of chloroform" @default.
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- W2087309148 doi "https://doi.org/10.1016/0006-291x(77)91166-4" @default.
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