FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2088307552> ?p ?o ?g. }

• W2088307552 endingPage "3954" @default.
• W2088307552 startingPage "3949" @default.
• W2088307552 abstract "Triplex DNA formation involving unmodified triplex-forming oligonucleotides (TFOs) is very unstable under physiological conditions. Here, we report a novel strategy to stabilize both purine and pyrimidine motif triplex DNA within the rat alpha1 (I) collagen gene promoter under physiologically relevant conditions by a poly(L-lysine)- graft -dextran copolymer. Using an in vitro electrophoretic mobility shift assay, we show that the copolymer almost completely abrogates the inhibitory effects of physiological concentrations of monovalent cations, particularly potassium ion (K+), on purine motif triplex formation involving very low concentrations of an unmodified guanine-rich TFO. Of importance, pH dependency in pyrimidine motif triplex formation involving an unmodified cytosine-rich TFO is also significantly overcome by the copolymer. Finally, the triplex-stabilizing efficiency of the copolymer is remarkably higher than that of other oligocations, like spermine and spermidine. We suggest that the ability of the graft copolymer to stabilize triplex DNA under physiologically relevant pH and salt concentrations will be a cue for further progress in the antigene strategy." @default.
• W2088307552 created "2016-06-24" @default.
• W2088307552 creator A5010867165 @default.
• W2088307552 creator A5024587258 @default.
• W2088307552 creator A5050358516 @default.
• W2088307552 creator A5071801912 @default.
• W2088307552 date "1998-09-01" @default.
• W2088307552 modified "2023-10-13" @default.
• W2088307552 title "Poly(L-lysine)-graft-dextran copolymer: amazing effects on triplex stabilization under physiological pH and ionic conditions (in vitro)" @default.
• W2088307552 cites W107358295 @default.
• W2088307552 cites W1539511666 @default.
• W2088307552 cites W1966342019 @default.
• W2088307552 cites W1978274422 @default.
• W2088307552 cites W1999222678 @default.
• W2088307552 cites W2003017660 @default.
• W2088307552 cites W2004059420 @default.
• W2088307552 cites W2017157816 @default.
• W2088307552 cites W2020586396 @default.
• W2088307552 cites W2020737102 @default.
• W2088307552 cites W2032069911 @default.
• W2088307552 cites W2033526098 @default.
• W2088307552 cites W2042209155 @default.
• W2088307552 cites W2045366550 @default.
• W2088307552 cites W2047209080 @default.
• W2088307552 cites W2052333294 @default.
• W2088307552 cites W2056012144 @default.
• W2088307552 cites W2061419481 @default.
• W2088307552 cites W2075053677 @default.
• W2088307552 cites W2076335297 @default.
• W2088307552 cites W2077281274 @default.
• W2088307552 cites W2081108249 @default.
• W2088307552 cites W2087066312 @default.
• W2088307552 cites W2088682009 @default.
• W2088307552 cites W2090353848 @default.
• W2088307552 cites W2090657198 @default.
• W2088307552 cites W2091406831 @default.
• W2088307552 cites W2091700323 @default.
• W2088307552 cites W2107142375 @default.
• W2088307552 cites W2123017921 @default.
• W2088307552 cites W2133918133 @default.
• W2088307552 cites W2151668141 @default.
• W2088307552 cites W2162505955 @default.
• W2088307552 cites W4238270754 @default.
• W2088307552 doi "https://doi.org/10.1093/nar/26.17.3949" @default.
• W2088307552 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/147801" @default.
• W2088307552 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9705503" @default.
• W2088307552 hasPublicationYear "1998" @default.
• W2088307552 type Work @default.
• W2088307552 sameAs 2088307552 @default.
• W2088307552 citedByCount "52" @default.
• W2088307552 countsByYear W20883075522013 @default.
• W2088307552 countsByYear W20883075522014 @default.
• W2088307552 countsByYear W20883075522015 @default.
• W2088307552 countsByYear W20883075522016 @default.
• W2088307552 countsByYear W20883075522017 @default.
• W2088307552 countsByYear W20883075522018 @default.
• W2088307552 countsByYear W20883075522019 @default.
• W2088307552 countsByYear W20883075522020 @default.
• W2088307552 countsByYear W20883075522023 @default.
• W2088307552 crossrefType "journal-article" @default.
• W2088307552 hasAuthorship W2088307552A5010867165 @default.
• W2088307552 hasAuthorship W2088307552A5024587258 @default.
• W2088307552 hasAuthorship W2088307552A5050358516 @default.
• W2088307552 hasAuthorship W2088307552A5071801912 @default.
• W2088307552 hasBestOaLocation W20883075521 @default.
• W2088307552 hasConcept C104317684 @default.
• W2088307552 hasConcept C12554922 @default.
• W2088307552 hasConcept C129312508 @default.
• W2088307552 hasConcept C150194340 @default.
• W2088307552 hasConcept C153911025 @default.
• W2088307552 hasConcept C15920480 @default.
• W2088307552 hasConcept C178790620 @default.
• W2088307552 hasConcept C181199279 @default.
• W2088307552 hasConcept C183978625 @default.
• W2088307552 hasConcept C185592680 @default.
• W2088307552 hasConcept C188027245 @default.
• W2088307552 hasConcept C202751555 @default.
• W2088307552 hasConcept C2776016237 @default.
• W2088307552 hasConcept C2776023528 @default.
• W2088307552 hasConcept C2776109719 @default.
• W2088307552 hasConcept C2776476023 @default.
• W2088307552 hasConcept C2777339698 @default.
• W2088307552 hasConcept C2777497464 @default.
• W2088307552 hasConcept C2778301229 @default.
• W2088307552 hasConcept C2779321679 @default.
• W2088307552 hasConcept C512185932 @default.
• W2088307552 hasConcept C515207424 @default.
• W2088307552 hasConcept C521977710 @default.
• W2088307552 hasConcept C552990157 @default.
• W2088307552 hasConcept C55493867 @default.
• W2088307552 hasConcept C86803240 @default.
• W2088307552 hasConceptScore W2088307552C104317684 @default.
• W2088307552 hasConceptScore W2088307552C12554922 @default.
• W2088307552 hasConceptScore W2088307552C129312508 @default.
• W2088307552 hasConceptScore W2088307552C150194340 @default.
• W2088307552 hasConceptScore W2088307552C153911025 @default.
• W2088307552 hasConceptScore W2088307552C15920480 @default.
• W2088307552 hasConceptScore W2088307552C178790620 @default.

• next