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- W2088917418 abstract "DNA double-strand breaks (DSBs) are among the most deleterious DNA lesions, which if unrepaired or repaired incorrectly can cause cell death or genome instability that may lead to cancer. To counteract these adverse consequences, eukaryotes have evolved a highly orchestrated mechanism to repair DSBs, namely DNA-damage-response (DDR). DDR, as defined specifically in relation to DSBs, consists of multi-layered regulatory modes including DNA damage sensors, transducers and effectors, through which DSBs are sensed and then repaired via DNAprotein interactions. Unexpectedly, recent studies have revealed a direct role of RNA in the repair of DSBs, including DSB-induced small RNA (diRNA)-directed and RNA-templated DNA repair. Here, we summarize the recent discoveries of RNA-mediated regulation of DSB repair and discuss the potential impact of these novel RNA components of the DSB repair pathway on genomic stability and plasticity." @default.
- W2088917418 created "2016-06-24" @default.
- W2088917418 creator A5052037541 @default.
- W2088917418 creator A5061966375 @default.
- W2088917418 date "2015-08-01" @default.
- W2088917418 modified "2023-10-17" @default.
- W2088917418 title "RNA-directed repair of DNA double-strand breaks" @default.
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- W2088917418 doi "https://doi.org/10.1016/j.dnarep.2015.04.017" @default.
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- W2088917418 hasPublicationYear "2015" @default.
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