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• W2090009277 abstract "We read with interest the recent crossover study of 47 patients with seasonal allergic rhinitis (SAR), which showed that 5 mg of desloratadine compared with placebo administered for 7 days in an allergen exposure unit resulted in improved subjective and objective outcomes of nasal obstruction.1Horak F Stubner UP Zieglmayer R Harris AG Effect of desloratadine versus placebo on nasal airflow and subjective measures of nasal obstruction in subjects with grass pollen-induced allergic rhinitis in an allergen-exposure unit.J Allergy Clin Immunol. 2002; 109: 956-961Abstract Full Text Full Text PDF PubMed Scopus (120) Google Scholar In the abstract it is stated that “unlike many antihistamines, desloratadine can reduce nasal congestion in patients with SAR,” which infers that this is a unique property of desloratadine. This assumption is not borne out by the published literature for other antihistamines. For example, in a crossover study of 37 patients with SAR during the grass pollen season, 2 weeks of treatment with 120 mg of fexo-fenadine once daily produced a significant improvement in domiciliary peak nasal inspiratory flow, amounting to a 9% increase, along with a significant 23% reduction in nasal blockage symptoms compared with placebo.2Wilson AM Orr LC Coutie WJ Sims EJ Lipworth BJ A comparison of once daily fexofenadine versus the combination of montelukast plus loratadine on domiciliary nasal peak flow and symptoms in seasonal allergic rhinitis.Clin Exp Allergy. 2002; 32: 126-132Crossref PubMed Scopus (55) Google Scholar In another study of 49 patients with SAR during the pollen season, 180 mg of fexofenadine once daily and 5 mg of desloratadine once daily administered for 2 weeks both produced a significant and comparable improvement in domiciliary peak nasal inspiratory flow (8% and 9% increase, respectively), as well as a significant reduction in nasal blockage symptom score (18% and 25% decrease, respectively).3Lipworth BJ Wilson AM Haggart K Sims EJ Differences in in-vitro H1-receptor antagonist potency with fexofenadine and desloratadine do not determine effects of nasal congestion in seasonal allergic rhinitis.Allergy. 2002; 57: 10PubMed Google Scholar Finally, in a parallel-group study of 31 patients with perennial allergic rhinitis, compared with placebo, treatment with 120 or 180 mg of fexofenadine once daily produced a significant decrease in the nasal blockage symptom score, which was seen after the first week.4Ciprandi G Cosentino C Milanese M Mondino C Canonica GW Fexo-fenadine reduces nasal congestion in perennial allergic rhinitis.Allergy. 2001; 56: 1068-1070Crossref PubMed Scopus (56) Google Scholar It would therefore appear that fexofenadine, like desloratadine, might exhibit decongestant effects on subjective and objective outcomes in patients with allergic rhinitis, which in turn suggests that this property is a class effect of antihistamines." @default.
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• W2090009277 date "2003-03-01" @default.
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• W2090009277 title "Decongestant effects of antihistamines: A class effect?" @default.
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• W2090009277 doi "https://doi.org/10.1067/mai.2003.115" @default.
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