FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2090416093> ?p ?o ?g. }

• W2090416093 endingPage "24" @default.
• W2090416093 startingPage "16" @default.
• W2090416093 abstract "Abstract BACKGROUND: Using a recent model of dissecting aortic aneurysm (DAA) caused by in utero exposure to semicarbazide, we examined the elastin and collagen using standard methods and two nonlinear imaging techniques, multiphoton fluorescence (MPF) and second harmonic generation (SHG) microscopy. METHODS: Sprague‐Dawley rat dams were given semicarbazide (6.13 mg/kg/day i.p.) from gestational days 14 to 20 (GD14–20). Fetuses were harvested on GD20 and pups on postnatal day 1 (PND1), PND7, and PND28; matched controls were from dams treated with saline. Aortic immunohistopathology and collagen/elastin signal intensity via MPF and SHG microscopy at an excitation wavelength of 800 nm were studied. RESULTS: Massive DAA of the aortic arch occurred in nearly 100% of pups at birth (i.e., no GD20 fetuses showed lesions). MPF and SHG demonstrated that collagen was significantly degraded at GD20 and in newborns, but normalized by PND28. GD20 fetuses and newborn pups showed a decreased content of medial and adventitial collagen type III in pooled aortas by Western blot and immunohistochemistry. In 7‐ and 28‐day‐old pups resolution of DAA blood in vascular media and a recovery of stainable collagen type III was found. Elastin in healed DAA (PND28 pups) was focally disorganized. CONCLUSION: MPF and SHG microscopy provide sensitive and high‐resolution information on aortic elastin and collagen. In this model of DAA, collagen displays aberrant imaging quality likely linked to a marked decrease in collagen type III in the developing extracellular matrix. Birth Defects Research (Part A) 2008. © 2007 Wiley‐Liss, Inc." @default.
• W2090416093 created "2016-06-24" @default.
• W2090416093 creator A5000381401 @default.
• W2090416093 creator A5006535608 @default.
• W2090416093 creator A5011791894 @default.
• W2090416093 creator A5041849892 @default.
• W2090416093 creator A5064569612 @default.
• W2090416093 creator A5081348340 @default.
• W2090416093 creator A5083604223 @default.
• W2090416093 date "2007-11-28" @default.
• W2090416093 modified "2023-10-13" @default.
• W2090416093 title "Nonlinear imaging study of extracellular matrix in chemical-induced, developmental dissecting aortic aneurysm: Evidence for defective collagen type III" @default.
• W2090416093 cites W1526243437 @default.
• W2090416093 cites W1583481604 @default.
• W2090416093 cites W1973491055 @default.
• W2090416093 cites W1976642508 @default.
• W2090416093 cites W1977548971 @default.
• W2090416093 cites W1987315996 @default.
• W2090416093 cites W1993639954 @default.
• W2090416093 cites W1996232545 @default.
• W2090416093 cites W2001391564 @default.
• W2090416093 cites W2002596946 @default.
• W2090416093 cites W2009710644 @default.
• W2090416093 cites W2019384293 @default.
• W2090416093 cites W2020009917 @default.
• W2090416093 cites W2021468281 @default.
• W2090416093 cites W2027081955 @default.
• W2090416093 cites W2033970221 @default.
• W2090416093 cites W2048962670 @default.
• W2090416093 cites W2054351373 @default.
• W2090416093 cites W2056467813 @default.
• W2090416093 cites W2056941285 @default.
• W2090416093 cites W2059032968 @default.
• W2090416093 cites W2062395208 @default.
• W2090416093 cites W2064023205 @default.
• W2090416093 cites W2065419824 @default.
• W2090416093 cites W2079738970 @default.
• W2090416093 cites W2080396851 @default.
• W2090416093 cites W2093042894 @default.
• W2090416093 cites W2097091783 @default.
• W2090416093 cites W2101449914 @default.
• W2090416093 cites W2103304528 @default.
• W2090416093 cites W2119518116 @default.
• W2090416093 cites W2122935525 @default.
• W2090416093 cites W2129339652 @default.
• W2090416093 cites W2161722088 @default.
• W2090416093 cites W2162211311 @default.
• W2090416093 cites W2168333054 @default.
• W2090416093 cites W2170941195 @default.
• W2090416093 cites W2172085460 @default.
• W2090416093 cites W2203655011 @default.
• W2090416093 cites W2277030622 @default.
• W2090416093 cites W4210984075 @default.
• W2090416093 cites W4323284458 @default.
• W2090416093 doi "https://doi.org/10.1002/bdra.20408" @default.
• W2090416093 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18044709" @default.
• W2090416093 hasPublicationYear "2007" @default.
• W2090416093 type Work @default.
• W2090416093 sameAs 2090416093 @default.
• W2090416093 citedByCount "13" @default.
• W2090416093 countsByYear W20904160932012 @default.
• W2090416093 countsByYear W20904160932014 @default.
• W2090416093 countsByYear W20904160932015 @default.
• W2090416093 countsByYear W20904160932016 @default.
• W2090416093 countsByYear W20904160932019 @default.
• W2090416093 crossrefType "journal-article" @default.
• W2090416093 hasAuthorship W2090416093A5000381401 @default.
• W2090416093 hasAuthorship W2090416093A5006535608 @default.
• W2090416093 hasAuthorship W2090416093A5011791894 @default.
• W2090416093 hasAuthorship W2090416093A5041849892 @default.
• W2090416093 hasAuthorship W2090416093A5064569612 @default.
• W2090416093 hasAuthorship W2090416093A5081348340 @default.
• W2090416093 hasAuthorship W2090416093A5083604223 @default.
• W2090416093 hasConcept C105702510 @default.
• W2090416093 hasConcept C126322002 @default.
• W2090416093 hasConcept C134018914 @default.
• W2090416093 hasConcept C142724271 @default.
• W2090416093 hasConcept C16685009 @default.
• W2090416093 hasConcept C172680121 @default.
• W2090416093 hasConcept C185592680 @default.
• W2090416093 hasConcept C189165786 @default.
• W2090416093 hasConcept C201614185 @default.
• W2090416093 hasConcept C2779234561 @default.
• W2090416093 hasConcept C2779869378 @default.
• W2090416093 hasConcept C2779980429 @default.
• W2090416093 hasConcept C2780644872 @default.
• W2090416093 hasConcept C54355233 @default.
• W2090416093 hasConcept C55493867 @default.
• W2090416093 hasConcept C71924100 @default.
• W2090416093 hasConcept C86803240 @default.
• W2090416093 hasConceptScore W2090416093C105702510 @default.
• W2090416093 hasConceptScore W2090416093C126322002 @default.
• W2090416093 hasConceptScore W2090416093C134018914 @default.
• W2090416093 hasConceptScore W2090416093C142724271 @default.
• W2090416093 hasConceptScore W2090416093C16685009 @default.
• W2090416093 hasConceptScore W2090416093C172680121 @default.
• W2090416093 hasConceptScore W2090416093C185592680 @default.
• W2090416093 hasConceptScore W2090416093C189165786 @default.

• next