FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2090802034> ?p ?o ?g. }

• W2090802034 endingPage "634" @default.
• W2090802034 startingPage "625" @default.
• W2090802034 abstract "Although glial cells missing (gcm) genes are known as glial determinants in the fly embryo, the role of vertebrate orthologs in the central nervous system is still under debate. Here we show for the first time that the chicken ortholog of fly gcm (herein referred to as c-Gcm1), is expressed in early neuronal lineages of the developing spinal cord and is required for neural progenitors to differentiate as neurons. Moreover, c-Gcm1 overexpression is sufficient to trigger cell cycle exit and neuronal differentiation in neural progenitors. Thus, c-Gcm1 expression constitutes a crucial step in the developmental cascade that prompts progenitors to generate neurons: c-Gcm1 acts downstream of proneural (neurogenin) and progenitor (Sox1-3) factors and upstream of NeuroM neuronal differentiation factor. Strikingly, this neurogenic role is not specific to the vertebrate gene, as fly gcmand gcm2 are also sufficient to induce the expression of neuronal markers. Interestingly, the neurogenic role is restricted to post-embryonic stages and we identify two novel brain neuronal lineages expressing and requiring gcm genes. Finally, we show that fly gcm and the chick and mouse orthologs induce expression of neural markers in HeLa cells. These data, which demonstrate a conserved neurogenic role for Gcm transcription factors, call for a re-evaluation of the mode of action of these genes during evolution." @default.
• W2090802034 created "2016-06-24" @default.
• W2090802034 creator A5012217065 @default.
• W2090802034 creator A5019492338 @default.
• W2090802034 creator A5025501813 @default.
• W2090802034 creator A5040953516 @default.
• W2090802034 creator A5055180965 @default.
• W2090802034 creator A5078971711 @default.
• W2090802034 creator A5087784713 @default.
• W2090802034 date "2007-02-01" @default.
• W2090802034 modified "2023-09-30" @default.
• W2090802034 title "Neurogenic role of Gcm transcription factors is conserved in chicken spinal cord" @default.
• W2090802034 cites W1487146757 @default.
• W2090802034 cites W1523918896 @default.
• W2090802034 cites W1527376733 @default.
• W2090802034 cites W1969123340 @default.
• W2090802034 cites W1969326097 @default.
• W2090802034 cites W1972794999 @default.
• W2090802034 cites W1974479702 @default.
• W2090802034 cites W1975154951 @default.
• W2090802034 cites W1978433429 @default.
• W2090802034 cites W1987175626 @default.
• W2090802034 cites W1989005003 @default.
• W2090802034 cites W1993000387 @default.
• W2090802034 cites W1996432459 @default.
• W2090802034 cites W2006047257 @default.
• W2090802034 cites W2009598941 @default.
• W2090802034 cites W2017848407 @default.
• W2090802034 cites W2028183921 @default.
• W2090802034 cites W2031683488 @default.
• W2090802034 cites W2034657677 @default.
• W2090802034 cites W2035222904 @default.
• W2090802034 cites W2036141030 @default.
• W2090802034 cites W2043655216 @default.
• W2090802034 cites W2046951891 @default.
• W2090802034 cites W2052655178 @default.
• W2090802034 cites W2054463240 @default.
• W2090802034 cites W2062052826 @default.
• W2090802034 cites W2077479555 @default.
• W2090802034 cites W2077549750 @default.
• W2090802034 cites W2080570840 @default.
• W2090802034 cites W2081092282 @default.
• W2090802034 cites W2086455816 @default.
• W2090802034 cites W2099993158 @default.
• W2090802034 cites W2108663844 @default.
• W2090802034 cites W2109177118 @default.
• W2090802034 cites W2134999463 @default.
• W2090802034 cites W2143341607 @default.
• W2090802034 cites W2172035437 @default.
• W2090802034 cites W2185218821 @default.
• W2090802034 cites W2186482582 @default.
• W2090802034 doi "https://doi.org/10.1242/dev.02750" @default.
• W2090802034 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17215311" @default.
• W2090802034 hasPublicationYear "2007" @default.
• W2090802034 type Work @default.
• W2090802034 sameAs 2090802034 @default.
• W2090802034 citedByCount "33" @default.
• W2090802034 countsByYear W20908020342012 @default.
• W2090802034 countsByYear W20908020342013 @default.
• W2090802034 countsByYear W20908020342014 @default.
• W2090802034 countsByYear W20908020342015 @default.
• W2090802034 countsByYear W20908020342016 @default.
• W2090802034 countsByYear W20908020342018 @default.
• W2090802034 countsByYear W20908020342021 @default.
• W2090802034 countsByYear W20908020342022 @default.
• W2090802034 countsByYear W20908020342023 @default.
• W2090802034 crossrefType "journal-article" @default.
• W2090802034 hasAuthorship W2090802034A5012217065 @default.
• W2090802034 hasAuthorship W2090802034A5019492338 @default.
• W2090802034 hasAuthorship W2090802034A5025501813 @default.
• W2090802034 hasAuthorship W2090802034A5040953516 @default.
• W2090802034 hasAuthorship W2090802034A5055180965 @default.
• W2090802034 hasAuthorship W2090802034A5078971711 @default.
• W2090802034 hasAuthorship W2090802034A5087784713 @default.
• W2090802034 hasBestOaLocation W20908020341 @default.
• W2090802034 hasConcept C104317684 @default.
• W2090802034 hasConcept C105702510 @default.
• W2090802034 hasConcept C132651083 @default.
• W2090802034 hasConcept C136834591 @default.
• W2090802034 hasConcept C141452985 @default.
• W2090802034 hasConcept C143742823 @default.
• W2090802034 hasConcept C145103041 @default.
• W2090802034 hasConcept C15729860 @default.
• W2090802034 hasConcept C169760540 @default.
• W2090802034 hasConcept C18903297 @default.
• W2090802034 hasConcept C201750760 @default.
• W2090802034 hasConcept C2780775167 @default.
• W2090802034 hasConcept C28328180 @default.
• W2090802034 hasConcept C54355233 @default.
• W2090802034 hasConcept C86339819 @default.
• W2090802034 hasConcept C86803240 @default.
• W2090802034 hasConcept C95444343 @default.
• W2090802034 hasConceptScore W2090802034C104317684 @default.
• W2090802034 hasConceptScore W2090802034C105702510 @default.
• W2090802034 hasConceptScore W2090802034C132651083 @default.
• W2090802034 hasConceptScore W2090802034C136834591 @default.
• W2090802034 hasConceptScore W2090802034C141452985 @default.
• W2090802034 hasConceptScore W2090802034C143742823 @default.

• next