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• W2091536410 abstract "The mechanism of tumor necrosis factor (TNF)-α signaling is unknown. TNF-α signaling may involve sphingomyelin hydrolysis to ceramide by a sphingomyelinase and stimulation of a ceramide-activated protein kinase. In a cell-free system, TNF-α induced a rapid reduction in membrane sphingomyelin content and a quantitative elevation in ceramide concentrations. Ceramide-activated protein kinase activity also increased. Kinase activation was mimicked by addition of sphingomyelinase but not by phospholipases A2, C, or D. Reconstitution of this cascade in a cell-free system demonstrates tight coupling to the receptor, suggesting this is a signal transduction pathway for TNF-α." @default.
• W2091536410 created "2016-06-24" @default.
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• W2091536410 date "1992-03-27" @default.
• W2091536410 modified "2023-10-17" @default.
• W2091536410 title "Tumor Necrosis Factor-α Activates the Sphingomyelin Signal Transduction Pathway in a Cell-Free System" @default.
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• W2091536410 doi "https://doi.org/10.1126/science.1313189" @default.
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