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- W2093377913 abstract "Addition of piperidines 15a-d to methylene lactones 8,14a gives the gamma-lactonized diphenylbutylpiperidine-type neuroleptics 3a,b,d,4a-d. 8 can be produced by cyclization or--as well as 14--from the corresponding alpha-carboxylactone. 1H- and 13C-nmr data give evidence for the equatorial position of the aminomethyl group in all derivatives of 3 and 4 and bisequatorial-trans-configuration in 4a-d. 3H-spiroperidole displacement at the D2 receptor in rat brain by 3,4 and the gamma-lactonized butyrophenone neuroleptics 1,2a-c was investigated. Some compounds show moderate up to high (3b) activity." @default.
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- W2093377913 date "1993-01-01" @default.
- W2093377913 modified "2023-10-16" @default.
- W2093377913 title "Lactone, 24. Mitt.: „γ-Lactonisierte” Neuroleptika - Synthese, Stereochemie und Affinität am D2-Rezeptor" @default.
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- W2093377913 doi "https://doi.org/10.1002/ardp.19933260508" @default.
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