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- W2094049971 abstract "Melanoma cells escape transforming growth factor-β (TGFβ)-mediated growth inhibition by expressing the Smad (mothers against decapentaplegic homolog, Drosophila) inhibitors Ski and Sno. Here, we demonstrate that melanoma inhibitory activity (MIA) influences the expression of these inhibitors. A Smad responsive reporter construct was activated after TGFβ1 treatment in the MIA-deficient cell clones but not in the parental cell line. According to this finding, the TGFβ target genes JunB and Id-1 showed a strong induction of expression. Additional analyses revealed that Ski and Sno, repressors of TGFβ/SMAD signaling, are not expressed in the MIA-deficient cells but in the parental cell line HMB2 and the mock control. Further investigation showed that Ski and Sno expression might be regulated via the mitogen-activated protein kinase (MAPK)/extracellular signal-regulated kinase (ERK) signaling cascade. Treatment of HMB2 cells with a MEK inhibitor revealed a reduction of Ski and Sno expression, which leads to the conclusion that, in our melanoma cell model, Ski and Sno expression is regulated via MAPK/ERK signaling." @default.
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- W2094049971 date "2006-08-01" @default.
- W2094049971 modified "2023-10-17" @default.
- W2094049971 title "Influence of melanoma inhibitory activity on transforming growth factor-beta signaling in malignant melanoma" @default.
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- W2094049971 doi "https://doi.org/10.1097/01.cmr.0000205021.17774.e7" @default.
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