FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2094602223> ?p ?o ?g. }

• W2094602223 endingPage "4772" @default.
• W2094602223 startingPage "4767" @default.
• W2094602223 abstract "Multidrug efflux transporters recognize a variety of structurally unrelated compounds for which the molecular basis is poorly understood. For the resistance nodulation and cell division (RND) inner membrane component AcrB of the AcrAB-TolC multidrug efflux system from Escherichia coli, drug binding occurs at the access and deep binding pockets. These two binding areas are separated by an 11-amino-acid-residue-containing switch loop whose conformational flexibility is speculated to be essential for drug binding and transport. A G616N substitution in the switch loop has a distinct and local effect on the orientation of the loop and on the ability to transport larger drugs. Here, we report a distinct phenotypical pattern of drug recognition and transport for the G616N variant, indicating that drug substrates with minimal projection areas of >70 Å(2) are less well transported than other substrates." @default.
• W2094602223 created "2016-06-24" @default.
• W2094602223 creator A5014023432 @default.
• W2094602223 creator A5026218665 @default.
• W2094602223 creator A5087340766 @default.
• W2094602223 date "2014-08-01" @default.
• W2094602223 modified "2023-10-10" @default.
• W2094602223 title "Switch-Loop Flexibility Affects Transport of Large Drugs by the Promiscuous AcrB Multidrug Efflux Transporter" @default.
• W2094602223 cites W1964509770 @default.
• W2094602223 cites W1968140197 @default.
• W2094602223 cites W1970803152 @default.
• W2094602223 cites W1977645333 @default.
• W2094602223 cites W1985400607 @default.
• W2094602223 cites W2010438788 @default.
• W2094602223 cites W2054823629 @default.
• W2094602223 cites W2056659809 @default.
• W2094602223 cites W2071083537 @default.
• W2094602223 cites W2077083161 @default.
• W2094602223 cites W2086941118 @default.
• W2094602223 cites W2108921801 @default.
• W2094602223 cites W2126327687 @default.
• W2094602223 cites W2132067013 @default.
• W2094602223 cites W2144998676 @default.
• W2094602223 cites W2149485676 @default.
• W2094602223 cites W2153601116 @default.
• W2094602223 cites W2155790235 @default.
• W2094602223 cites W2334194304 @default.
• W2094602223 doi "https://doi.org/10.1128/aac.02733-13" @default.
• W2094602223 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4136034" @default.
• W2094602223 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24914123" @default.
• W2094602223 hasPublicationYear "2014" @default.
• W2094602223 type Work @default.
• W2094602223 sameAs 2094602223 @default.
• W2094602223 citedByCount "43" @default.
• W2094602223 countsByYear W20946022232015 @default.
• W2094602223 countsByYear W20946022232016 @default.
• W2094602223 countsByYear W20946022232017 @default.
• W2094602223 countsByYear W20946022232018 @default.
• W2094602223 countsByYear W20946022232019 @default.
• W2094602223 countsByYear W20946022232020 @default.
• W2094602223 countsByYear W20946022232021 @default.
• W2094602223 countsByYear W20946022232022 @default.
• W2094602223 countsByYear W20946022232023 @default.
• W2094602223 crossrefType "journal-article" @default.
• W2094602223 hasAuthorship W2094602223A5014023432 @default.
• W2094602223 hasAuthorship W2094602223A5026218665 @default.
• W2094602223 hasAuthorship W2094602223A5087340766 @default.
• W2094602223 hasBestOaLocation W20946022231 @default.
• W2094602223 hasConcept C104317684 @default.
• W2094602223 hasConcept C107824862 @default.
• W2094602223 hasConcept C115335371 @default.
• W2094602223 hasConcept C12554922 @default.
• W2094602223 hasConcept C133936738 @default.
• W2094602223 hasConcept C149011108 @default.
• W2094602223 hasConcept C185592680 @default.
• W2094602223 hasConcept C200082930 @default.
• W2094602223 hasConcept C2910769707 @default.
• W2094602223 hasConcept C41625074 @default.
• W2094602223 hasConcept C44312359 @default.
• W2094602223 hasConcept C501593827 @default.
• W2094602223 hasConcept C547475151 @default.
• W2094602223 hasConcept C55493867 @default.
• W2094602223 hasConcept C57581600 @default.
• W2094602223 hasConcept C57947595 @default.
• W2094602223 hasConcept C86803240 @default.
• W2094602223 hasConcept C95444343 @default.
• W2094602223 hasConceptScore W2094602223C104317684 @default.
• W2094602223 hasConceptScore W2094602223C107824862 @default.
• W2094602223 hasConceptScore W2094602223C115335371 @default.
• W2094602223 hasConceptScore W2094602223C12554922 @default.
• W2094602223 hasConceptScore W2094602223C133936738 @default.
• W2094602223 hasConceptScore W2094602223C149011108 @default.
• W2094602223 hasConceptScore W2094602223C185592680 @default.
• W2094602223 hasConceptScore W2094602223C200082930 @default.
• W2094602223 hasConceptScore W2094602223C2910769707 @default.
• W2094602223 hasConceptScore W2094602223C41625074 @default.
• W2094602223 hasConceptScore W2094602223C44312359 @default.
• W2094602223 hasConceptScore W2094602223C501593827 @default.
• W2094602223 hasConceptScore W2094602223C547475151 @default.
• W2094602223 hasConceptScore W2094602223C55493867 @default.
• W2094602223 hasConceptScore W2094602223C57581600 @default.
• W2094602223 hasConceptScore W2094602223C57947595 @default.
• W2094602223 hasConceptScore W2094602223C86803240 @default.
• W2094602223 hasConceptScore W2094602223C95444343 @default.
• W2094602223 hasIssue "8" @default.
• W2094602223 hasLocation W20946022231 @default.
• W2094602223 hasLocation W20946022232 @default.
• W2094602223 hasLocation W20946022233 @default.
• W2094602223 hasLocation W20946022234 @default.
• W2094602223 hasOpenAccess W2094602223 @default.
• W2094602223 hasPrimaryLocation W20946022231 @default.
• W2094602223 hasRelatedWork W2024339699 @default.
• W2094602223 hasRelatedWork W2038271205 @default.
• W2094602223 hasRelatedWork W2094602223 @default.
• W2094602223 hasRelatedWork W2127444056 @default.
• W2094602223 hasRelatedWork W2204704292 @default.
• W2094602223 hasRelatedWork W2312791182 @default.
• W2094602223 hasRelatedWork W2461174972 @default.

• next