FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2094644910> ?p ?o ?g. }

• W2094644910 endingPage "317" @default.
• W2094644910 startingPage "310" @default.
• W2094644910 abstract "Abstract Background The aim of this study was to assess the predictive value of tumor expression of nine genes on clinical outcome in patients with advanced NSCLC receiving platinum–gemcitabine chemotherapy. Methods Quantitative PCR or immunohistochemistry were used to analyze the expression of β-tubuline IIA (TUBB2A), β-tubuline III (TUBB3), BRCA1, ERCC1, Abraxas (ABRX) and RAP80 in mRNA isolated from paraffin-embedded tumor biopsies of 45 NSCLC patients treated as part of a larger observational trial. All patients received first-line platinum–gemcitabine chemotherapy for stage IIIB or IV NSCLC. Results Median progression-free survival (PFS) was 7 months, overall survival (OS) 12 months. A partial treatment response was found in 14 patients (33%). Patients with low ERCC1 or ABRX expression had a significantly better response to chemotherapy ( R  = −0.45, p R  = −0.40, p  = 0.016 for ABRX). A significant correlation was found between the individual time for PFS and the expression of both ERCC1 ( R  = −0.36, p  = 0.015) and ABRX ( R  = −0.46, p  = 0.001). Patients with low ERCC1 expression had a longer OS as compared to patients with high ERCC1 expression (HR = 0.26, log-rank p  = 0.02). Conclusions The study confirms tumor expression of ERCC1 as a predictor for clinical outcome in patients with advanced NSCLC receiving platinum-based chemotherapy, and found ABRX expression to be similarly predictive of clinical outcome. Prospective validation is warranted and – if confirmed – non platinum-containing chemotherapy should be explored as the preferred treatment in patients with high ERCC1 or ABRX expression and no activating mutations of EGFR." @default.
• W2094644910 created "2016-06-24" @default.
• W2094644910 creator A5000418012 @default.
• W2094644910 creator A5022167252 @default.
• W2094644910 creator A5024455958 @default.
• W2094644910 creator A5025499001 @default.
• W2094644910 creator A5030456356 @default.
• W2094644910 creator A5041613315 @default.
• W2094644910 creator A5049735686 @default.
• W2094644910 creator A5054076597 @default.
• W2094644910 date "2011-11-01" @default.
• W2094644910 modified "2023-09-27" @default.
• W2094644910 title "Tubuline, BRCA1, ERCC1, Abraxas, RAP80 mRNA expression, p53/p21 immunohistochemistry and clinical outcome in patients with advanced non small-cell lung cancer receiving first-line platinum–gemcitabine chemotherapy" @default.
• W2094644910 cites W1605249880 @default.
• W2094644910 cites W1968943627 @default.
• W2094644910 cites W1970609694 @default.
• W2094644910 cites W1971401701 @default.
• W2094644910 cites W1989800108 @default.
• W2094644910 cites W1993446755 @default.
• W2094644910 cites W2004629780 @default.
• W2094644910 cites W2004718750 @default.
• W2094644910 cites W2008191260 @default.
• W2094644910 cites W2008396969 @default.
• W2094644910 cites W2021363911 @default.
• W2094644910 cites W2022176772 @default.
• W2094644910 cites W2027640690 @default.
• W2094644910 cites W2030196526 @default.
• W2094644910 cites W2046238584 @default.
• W2094644910 cites W2047621538 @default.
• W2094644910 cites W2048454522 @default.
• W2094644910 cites W2050119069 @default.
• W2094644910 cites W2059822676 @default.
• W2094644910 cites W2069278782 @default.
• W2094644910 cites W2070906989 @default.
• W2094644910 cites W2072981858 @default.
• W2094644910 cites W2074459357 @default.
• W2094644910 cites W2078457029 @default.
• W2094644910 cites W2079658430 @default.
• W2094644910 cites W2081641598 @default.
• W2094644910 cites W2096289704 @default.
• W2094644910 cites W2098514397 @default.
• W2094644910 cites W2110468894 @default.
• W2094644910 cites W2112503651 @default.
• W2094644910 cites W2121110745 @default.
• W2094644910 cites W2124392685 @default.
• W2094644910 cites W2135836212 @default.
• W2094644910 cites W2144483035 @default.
• W2094644910 cites W2164432834 @default.
• W2094644910 cites W2165112400 @default.
• W2094644910 cites W2169668454 @default.
• W2094644910 doi "https://doi.org/10.1016/j.lungcan.2011.03.016" @default.
• W2094644910 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21529986" @default.
• W2094644910 hasPublicationYear "2011" @default.
• W2094644910 type Work @default.
• W2094644910 sameAs 2094644910 @default.
• W2094644910 citedByCount "22" @default.
• W2094644910 countsByYear W20946449102012 @default.
• W2094644910 countsByYear W20946449102013 @default.
• W2094644910 countsByYear W20946449102014 @default.
• W2094644910 countsByYear W20946449102015 @default.
• W2094644910 countsByYear W20946449102016 @default.
• W2094644910 countsByYear W20946449102017 @default.
• W2094644910 countsByYear W20946449102020 @default.
• W2094644910 countsByYear W20946449102021 @default.
• W2094644910 countsByYear W20946449102022 @default.
• W2094644910 crossrefType "journal-article" @default.
• W2094644910 hasAuthorship W2094644910A5000418012 @default.
• W2094644910 hasAuthorship W2094644910A5022167252 @default.
• W2094644910 hasAuthorship W2094644910A5024455958 @default.
• W2094644910 hasAuthorship W2094644910A5025499001 @default.
• W2094644910 hasAuthorship W2094644910A5030456356 @default.
• W2094644910 hasAuthorship W2094644910A5041613315 @default.
• W2094644910 hasAuthorship W2094644910A5049735686 @default.
• W2094644910 hasAuthorship W2094644910A5054076597 @default.
• W2094644910 hasConcept C104317684 @default.
• W2094644910 hasConcept C104451858 @default.
• W2094644910 hasConcept C126322002 @default.
• W2094644910 hasConcept C134935766 @default.
• W2094644910 hasConcept C143998085 @default.
• W2094644910 hasConcept C204232928 @default.
• W2094644910 hasConcept C2776256026 @default.
• W2094644910 hasConcept C2776694085 @default.
• W2094644910 hasConcept C2778239845 @default.
• W2094644910 hasConcept C2779309665 @default.
• W2094644910 hasConcept C2780258809 @default.
• W2094644910 hasConcept C3017404179 @default.
• W2094644910 hasConcept C502942594 @default.
• W2094644910 hasConcept C55493867 @default.
• W2094644910 hasConcept C71924100 @default.
• W2094644910 hasConcept C86803240 @default.
• W2094644910 hasConceptScore W2094644910C104317684 @default.
• W2094644910 hasConceptScore W2094644910C104451858 @default.
• W2094644910 hasConceptScore W2094644910C126322002 @default.
• W2094644910 hasConceptScore W2094644910C134935766 @default.
• W2094644910 hasConceptScore W2094644910C143998085 @default.
• W2094644910 hasConceptScore W2094644910C204232928 @default.
• W2094644910 hasConceptScore W2094644910C2776256026 @default.
• W2094644910 hasConceptScore W2094644910C2776694085 @default.

• next