FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2095435791> ?p ?o ?g. }

• W2095435791 endingPage "168" @default.
• W2095435791 startingPage "158" @default.
• W2095435791 abstract "Lipoxygenase (LO) products generated by human PMN were examined utilizing a gradient-HPLC and rapid spectral detector which permitted continuous UV-spectral monitoring of leukotrienes, lipoxins and related oxygenated products of arachidonic acid. When exposed to the ionophore A23187, PMN generated LTB4 and its ω-oxidation products as well as LXA4, LXB4, and 7-cis-11-trans-LXA4 from endogenous sources. Addition of 15-HETE changed the profile of products generated by activated PMN and led to a time- and dose-dependent increase in lipoxins and related compounds while the production of LTB4 and its ω-oxidation products was inhibited. Results of time-course and radiolabel studies revealed that 15-HETE is rapidly transformed within 15 s to 5,15-DHETE and conjugated tetraene-containing products, and that the inhibition of leukotriene formation followed a similar time-course. In contrast, PMN did not generate either lipoxins or related products from 5-[3H]HETE, nor did 5-HETE block leukotriene formation. Stimulated PMN generated 5,15-DHETE from exogenous 5-HETE, while in the absence of ionophore, 5-HETE was transformed to 5,20-HETE. These results indicate that PMN can generate lipoxins and related products from endogenous sources and that 15-HETE and 5-HETE are transformed by different routes." @default.
• W2095435791 created "2016-06-24" @default.
• W2095435791 creator A5029525374 @default.
• W2095435791 date "1989-08-01" @default.
• W2095435791 modified "2023-10-18" @default.
• W2095435791 title "On the relationship between leukotriene and lipoxin production by human neutrophils: evidence for differential metabolism of 15-HETE and 5-HETE" @default.
• W2095435791 cites W1491680804 @default.
• W2095435791 cites W1494464010 @default.
• W2095435791 cites W1517088677 @default.
• W2095435791 cites W1533580349 @default.
• W2095435791 cites W1559174460 @default.
• W2095435791 cites W1575328011 @default.
• W2095435791 cites W1604010542 @default.
• W2095435791 cites W1615557421 @default.
• W2095435791 cites W1967932034 @default.
• W2095435791 cites W1971748651 @default.
• W2095435791 cites W1977506430 @default.
• W2095435791 cites W1992220924 @default.
• W2095435791 cites W1997414475 @default.
• W2095435791 cites W2003890116 @default.
• W2095435791 cites W2004731177 @default.
• W2095435791 cites W2010550697 @default.
• W2095435791 cites W2014391037 @default.
• W2095435791 cites W2022910551 @default.
• W2095435791 cites W2023125766 @default.
• W2095435791 cites W2024176341 @default.
• W2095435791 cites W2029791404 @default.
• W2095435791 cites W2040892973 @default.
• W2095435791 cites W2042518131 @default.
• W2095435791 cites W2053528210 @default.
• W2095435791 cites W2055038552 @default.
• W2095435791 cites W2068106905 @default.
• W2095435791 cites W2077754117 @default.
• W2095435791 cites W2079790969 @default.
• W2095435791 cites W2090805356 @default.
• W2095435791 cites W2091021798 @default.
• W2095435791 cites W2092409117 @default.
• W2095435791 cites W2099192757 @default.
• W2095435791 cites W2141817909 @default.
• W2095435791 cites W2165191737 @default.
• W2095435791 cites W2331980604 @default.
• W2095435791 cites W2408503582 @default.
• W2095435791 cites W271818902 @default.
• W2095435791 cites W4231614298 @default.
• W2095435791 cites W83755377 @default.
• W2095435791 doi "https://doi.org/10.1016/0005-2760(89)90264-6" @default.
• W2095435791 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2546590" @default.
• W2095435791 hasPublicationYear "1989" @default.
• W2095435791 type Work @default.
• W2095435791 sameAs 2095435791 @default.
• W2095435791 citedByCount "78" @default.
• W2095435791 countsByYear W20954357912012 @default.
• W2095435791 countsByYear W20954357912014 @default.
• W2095435791 countsByYear W20954357912015 @default.
• W2095435791 countsByYear W20954357912016 @default.
• W2095435791 countsByYear W20954357912017 @default.
• W2095435791 countsByYear W20954357912018 @default.
• W2095435791 countsByYear W20954357912019 @default.
• W2095435791 countsByYear W20954357912020 @default.
• W2095435791 countsByYear W20954357912021 @default.
• W2095435791 countsByYear W20954357912022 @default.
• W2095435791 countsByYear W20954357912023 @default.
• W2095435791 crossrefType "journal-article" @default.
• W2095435791 hasAuthorship W2095435791A5029525374 @default.
• W2095435791 hasConcept C16613235 @default.
• W2095435791 hasConcept C170493617 @default.
• W2095435791 hasConcept C181199279 @default.
• W2095435791 hasConcept C185592680 @default.
• W2095435791 hasConcept C198677920 @default.
• W2095435791 hasConcept C202751555 @default.
• W2095435791 hasConcept C203014093 @default.
• W2095435791 hasConcept C2776042228 @default.
• W2095435791 hasConcept C2776452501 @default.
• W2095435791 hasConcept C2776685179 @default.
• W2095435791 hasConcept C2776914184 @default.
• W2095435791 hasConcept C2777983669 @default.
• W2095435791 hasConcept C2778078955 @default.
• W2095435791 hasConcept C2779014961 @default.
• W2095435791 hasConcept C2779543280 @default.
• W2095435791 hasConcept C2780415110 @default.
• W2095435791 hasConcept C2780857362 @default.
• W2095435791 hasConcept C41625074 @default.
• W2095435791 hasConcept C55493867 @default.
• W2095435791 hasConcept C62231903 @default.
• W2095435791 hasConcept C86803240 @default.
• W2095435791 hasConcept C90342290 @default.
• W2095435791 hasConceptScore W2095435791C16613235 @default.
• W2095435791 hasConceptScore W2095435791C170493617 @default.
• W2095435791 hasConceptScore W2095435791C181199279 @default.
• W2095435791 hasConceptScore W2095435791C185592680 @default.
• W2095435791 hasConceptScore W2095435791C198677920 @default.
• W2095435791 hasConceptScore W2095435791C202751555 @default.
• W2095435791 hasConceptScore W2095435791C203014093 @default.
• W2095435791 hasConceptScore W2095435791C2776042228 @default.
• W2095435791 hasConceptScore W2095435791C2776452501 @default.
• W2095435791 hasConceptScore W2095435791C2776685179 @default.
• W2095435791 hasConceptScore W2095435791C2776914184 @default.
• W2095435791 hasConceptScore W2095435791C2777983669 @default.

• next