FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2099201092> ?p ?o ?g. }

• W2099201092 endingPage "307" @default.
• W2099201092 startingPage "298" @default.
• W2099201092 abstract "Arsenic is a known teratogen and developmental toxicant in many animal models. The aim of the present study was to determine the influence of arsenic oxidation state, concentration, duration of exposure, and embryonic gestational age on arsenic-induced developmental toxicity. For these studies whole embryo culture was used since this experimental model allows an assessment of the direct effect of the toxicant on the embryo and precise control of the variables of interest. ICR and CD1 mouse embryos were prepared for whole embryo culture and exposed to concentrations of trivalent (1, 2, 5, 7.5, 10, 20, and 30 microM of sodium arsenite) and pentavalent arsenic (5, 10, 20, 50, and 100 microM of sodium arsenate) at different developmental stages (3, 4-6, 8-10, or 20-23 pairs of somites) and for different exposure periods (1, 4, 6, or 24 hr). Embryonic growth, development, malformation rates, and viability were evaluated. A comparison of the ED50s of the two oxidation states showed that arsenite was about three times more potent than arsenate with respect to both malformations and lethality. The pattern of malformations was similar for both arsenite and arsenate and involved nonclosure of the cranial neural tube, prosencephalic hypoplasia, dysmorphogenesis of the optic and otic anlagen, and pharyngeal arch defects. ICR conceptuses were more sensitive than CD1s with regard to perturbation in embryonic growth by both forms of arsenic. ICRs were also more sensitive to otic, pharyngeal arch, and somite dysmorphogenesis induced by arsenite. With increasing gestational age there was an increasing resistance to arsenic-induced effects. In comparison to the 4-6 somite stage, the ED50 for induction of dysmorphogenesis was increased about twice at the 8-10 somite and over three times in 20-23 somite stage embryos. Exposure to arsenite/arsenate for a 1-hr period was sufficient to induce maldevelopment. A 6-hr exposure induced prosencephalic, otic, and optic abnormal development at a rate similar to that produced by a 24-hr exposure. The malformation pattern produced by exposure to arsenite/arsenate in vitro closely corresponds to that produced by maternal administration at the same gestational stage. This indicates that the arsenic embryopathy may be the result of a direct impact of the agent on the conceptus." @default.
• W2099201092 created "2016-06-24" @default.
• W2099201092 creator A5003563724 @default.
• W2099201092 creator A5020056987 @default.
• W2099201092 creator A5070523775 @default.
• W2099201092 date "1996-06-01" @default.
• W2099201092 modified "2023-09-30" @default.
• W2099201092 title "Developmental Toxicity of Inorganic Arsenic in Whole Embryo Culture: Oxidation State, Dose, Time, and Gestational Age Dependence" @default.
• W2099201092 doi "https://doi.org/10.1006/taap.1996.0128" @default.
• W2099201092 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8658531" @default.
• W2099201092 hasPublicationYear "1996" @default.
• W2099201092 type Work @default.
• W2099201092 sameAs 2099201092 @default.
• W2099201092 citedByCount "56" @default.
• W2099201092 countsByYear W20992010922012 @default.
• W2099201092 countsByYear W20992010922013 @default.
• W2099201092 countsByYear W20992010922014 @default.
• W2099201092 countsByYear W20992010922015 @default.
• W2099201092 countsByYear W20992010922016 @default.
• W2099201092 countsByYear W20992010922018 @default.
• W2099201092 countsByYear W20992010922019 @default.
• W2099201092 countsByYear W20992010922020 @default.
• W2099201092 countsByYear W20992010922022 @default.
• W2099201092 countsByYear W20992010922023 @default.
• W2099201092 crossrefType "journal-article" @default.
• W2099201092 hasAuthorship W2099201092A5003563724 @default.
• W2099201092 hasAuthorship W2099201092A5020056987 @default.
• W2099201092 hasAuthorship W2099201092A5070523775 @default.
• W2099201092 hasConcept C126322002 @default.
• W2099201092 hasConcept C134018914 @default.
• W2099201092 hasConcept C16685009 @default.
• W2099201092 hasConcept C172507514 @default.
• W2099201092 hasConcept C178790620 @default.
• W2099201092 hasConcept C179335377 @default.
• W2099201092 hasConcept C185592680 @default.
• W2099201092 hasConcept C195289149 @default.
• W2099201092 hasConcept C196843134 @default.
• W2099201092 hasConcept C19749203 @default.
• W2099201092 hasConcept C2776305511 @default.
• W2099201092 hasConcept C2776630066 @default.
• W2099201092 hasConcept C2777764464 @default.
• W2099201092 hasConcept C2778177303 @default.
• W2099201092 hasConcept C2779018604 @default.
• W2099201092 hasConcept C2779234561 @default.
• W2099201092 hasConcept C2779495234 @default.
• W2099201092 hasConcept C2780473477 @default.
• W2099201092 hasConcept C29730261 @default.
• W2099201092 hasConcept C33070731 @default.
• W2099201092 hasConcept C46973012 @default.
• W2099201092 hasConcept C502230775 @default.
• W2099201092 hasConcept C54355233 @default.
• W2099201092 hasConcept C65290608 @default.
• W2099201092 hasConcept C71924100 @default.
• W2099201092 hasConcept C86803240 @default.
• W2099201092 hasConcept C87073359 @default.
• W2099201092 hasConceptScore W2099201092C126322002 @default.
• W2099201092 hasConceptScore W2099201092C134018914 @default.
• W2099201092 hasConceptScore W2099201092C16685009 @default.
• W2099201092 hasConceptScore W2099201092C172507514 @default.
• W2099201092 hasConceptScore W2099201092C178790620 @default.
• W2099201092 hasConceptScore W2099201092C179335377 @default.
• W2099201092 hasConceptScore W2099201092C185592680 @default.
• W2099201092 hasConceptScore W2099201092C195289149 @default.
• W2099201092 hasConceptScore W2099201092C196843134 @default.
• W2099201092 hasConceptScore W2099201092C19749203 @default.
• W2099201092 hasConceptScore W2099201092C2776305511 @default.
• W2099201092 hasConceptScore W2099201092C2776630066 @default.
• W2099201092 hasConceptScore W2099201092C2777764464 @default.
• W2099201092 hasConceptScore W2099201092C2778177303 @default.
• W2099201092 hasConceptScore W2099201092C2779018604 @default.
• W2099201092 hasConceptScore W2099201092C2779234561 @default.
• W2099201092 hasConceptScore W2099201092C2779495234 @default.
• W2099201092 hasConceptScore W2099201092C2780473477 @default.
• W2099201092 hasConceptScore W2099201092C29730261 @default.
• W2099201092 hasConceptScore W2099201092C33070731 @default.
• W2099201092 hasConceptScore W2099201092C46973012 @default.
• W2099201092 hasConceptScore W2099201092C502230775 @default.
• W2099201092 hasConceptScore W2099201092C54355233 @default.
• W2099201092 hasConceptScore W2099201092C65290608 @default.
• W2099201092 hasConceptScore W2099201092C71924100 @default.
• W2099201092 hasConceptScore W2099201092C86803240 @default.
• W2099201092 hasConceptScore W2099201092C87073359 @default.
• W2099201092 hasIssue "2" @default.
• W2099201092 hasLocation W20992010921 @default.
• W2099201092 hasLocation W20992010922 @default.
• W2099201092 hasOpenAccess W2099201092 @default.
• W2099201092 hasPrimaryLocation W20992010921 @default.
• W2099201092 hasRelatedWork W1830275345 @default.
• W2099201092 hasRelatedWork W1974239718 @default.
• W2099201092 hasRelatedWork W1985493312 @default.
• W2099201092 hasRelatedWork W2053734013 @default.
• W2099201092 hasRelatedWork W2072923766 @default.
• W2099201092 hasRelatedWork W2099201092 @default.
• W2099201092 hasRelatedWork W2133656238 @default.
• W2099201092 hasRelatedWork W2139614248 @default.
• W2099201092 hasRelatedWork W35776728 @default.
• W2099201092 hasRelatedWork W2184274880 @default.
• W2099201092 hasVolume "138" @default.

• next