FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2103058712> ?p ?o ?g. }

• W2103058712 endingPage "14" @default.
• W2103058712 startingPage "14" @default.
• W2103058712 abstract "Hydnophytum formicarium Jack is an epyphytic shrub that belongs to the family of Rubiaceae and is native to the tropical rain forests of the Asean region, which includes Malaysia. A flavanoid derivative, 7, 3', 5'-trihydroxyflavanone (3HFD), isolated from H. formicarium has been reported to have cytotoxic effects on the human breast carcinoma cell line MCF-7. The aim of the current study was to investigate the mode of cell death in MCF-7 cells treated with 3HFD. A DNA fragmentation assay was conducted on isolated genomic DNA, a TUNEL assay was used to determine the mode of cell death and Western blotting was used to evaluate the expression levels of Bax and Bcl-2. Immunofluorescence staining of MCF-7 cells was also performed to confirm the up-regulation of the Bax protein.The ladder pattern resulting from the DNA fragmentation assay was a multimer of 180 kb. The morphological changes of cells undergoing apoptosis were visualised by a TUNEL assay over time. The percentage of apoptotic cells increased as early as 6 hours post treatment compared to untreated cells. Western blotting revealed up-regulation of the pro-apoptotic protein Bax. However, 3HFD did not affect expression of the anti-apoptotic protein Bcl-2.Our results provide evidence that plant-derived 3HFD was able to induce the apoptotic cell death of MCF-7 cells by increasing Bax expression level and makes 3HFD a promising agent for chemotherapy, which merits further study." @default.
• W2103058712 created "2016-06-24" @default.
• W2103058712 creator A5032248882 @default.
• W2103058712 creator A5058006275 @default.
• W2103058712 creator A5067792910 @default.
• W2103058712 creator A5084183893 @default.
• W2103058712 date "2010-01-01" @default.
• W2103058712 modified "2023-09-25" @default.
• W2103058712 title "A natural compound from Hydnophytum formicarium induces apoptosis of MCF-7 cells via up-regulation of Bax" @default.
• W2103058712 cites W103784118 @default.
• W2103058712 cites W1489400525 @default.
• W2103058712 cites W1494870618 @default.
• W2103058712 cites W1498586399 @default.
• W2103058712 cites W153830316 @default.
• W2103058712 cites W167314582 @default.
• W2103058712 cites W1805030384 @default.
• W2103058712 cites W1964617786 @default.
• W2103058712 cites W1972105073 @default.
• W2103058712 cites W1981538055 @default.
• W2103058712 cites W1983386156 @default.
• W2103058712 cites W1987390316 @default.
• W2103058712 cites W1994039691 @default.
• W2103058712 cites W1995417847 @default.
• W2103058712 cites W2004397145 @default.
• W2103058712 cites W2042928863 @default.
• W2103058712 cites W2045086385 @default.
• W2103058712 cites W2049320179 @default.
• W2103058712 cites W2049970571 @default.
• W2103058712 cites W2052420233 @default.
• W2103058712 cites W2059561866 @default.
• W2103058712 cites W2075576299 @default.
• W2103058712 cites W2077987011 @default.
• W2103058712 cites W2127132946 @default.
• W2103058712 cites W2128697833 @default.
• W2103058712 cites W2134979684 @default.
• W2103058712 cites W2138302361 @default.
• W2103058712 cites W221630709 @default.
• W2103058712 cites W2295110019 @default.
• W2103058712 cites W2400257376 @default.
• W2103058712 cites W2403695590 @default.
• W2103058712 cites W242065769 @default.
• W2103058712 cites W288318664 @default.
• W2103058712 cites W54069900 @default.
• W2103058712 cites W88775432 @default.
• W2103058712 cites W2013185575 @default.
• W2103058712 doi "https://doi.org/10.1186/1475-2867-10-14" @default.
• W2103058712 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2873331" @default.
• W2103058712 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20441573" @default.
• W2103058712 hasPublicationYear "2010" @default.
• W2103058712 type Work @default.
• W2103058712 sameAs 2103058712 @default.
• W2103058712 citedByCount "13" @default.
• W2103058712 countsByYear W21030587122012 @default.
• W2103058712 countsByYear W21030587122013 @default.
• W2103058712 countsByYear W21030587122014 @default.
• W2103058712 countsByYear W21030587122015 @default.
• W2103058712 countsByYear W21030587122016 @default.
• W2103058712 countsByYear W21030587122017 @default.
• W2103058712 countsByYear W21030587122020 @default.
• W2103058712 countsByYear W21030587122021 @default.
• W2103058712 crossrefType "journal-article" @default.
• W2103058712 hasAuthorship W2103058712A5032248882 @default.
• W2103058712 hasAuthorship W2103058712A5058006275 @default.
• W2103058712 hasAuthorship W2103058712A5067792910 @default.
• W2103058712 hasAuthorship W2103058712A5084183893 @default.
• W2103058712 hasBestOaLocation W21030587121 @default.
• W2103058712 hasConcept C104317684 @default.
• W2103058712 hasConcept C109541995 @default.
• W2103058712 hasConcept C121608353 @default.
• W2103058712 hasConcept C153911025 @default.
• W2103058712 hasConcept C154317977 @default.
• W2103058712 hasConcept C185592680 @default.
• W2103058712 hasConcept C18903297 @default.
• W2103058712 hasConcept C190283241 @default.
• W2103058712 hasConcept C191015642 @default.
• W2103058712 hasConcept C196795494 @default.
• W2103058712 hasConcept C202751555 @default.
• W2103058712 hasConcept C2994423619 @default.
• W2103058712 hasConcept C31573885 @default.
• W2103058712 hasConcept C43759708 @default.
• W2103058712 hasConcept C502942594 @default.
• W2103058712 hasConcept C54355233 @default.
• W2103058712 hasConcept C55493867 @default.
• W2103058712 hasConcept C81885089 @default.
• W2103058712 hasConcept C85265743 @default.
• W2103058712 hasConcept C86803240 @default.
• W2103058712 hasConcept C96232424 @default.
• W2103058712 hasConceptScore W2103058712C104317684 @default.
• W2103058712 hasConceptScore W2103058712C109541995 @default.
• W2103058712 hasConceptScore W2103058712C121608353 @default.
• W2103058712 hasConceptScore W2103058712C153911025 @default.
• W2103058712 hasConceptScore W2103058712C154317977 @default.
• W2103058712 hasConceptScore W2103058712C185592680 @default.
• W2103058712 hasConceptScore W2103058712C18903297 @default.
• W2103058712 hasConceptScore W2103058712C190283241 @default.
• W2103058712 hasConceptScore W2103058712C191015642 @default.
• W2103058712 hasConceptScore W2103058712C196795494 @default.
• W2103058712 hasConceptScore W2103058712C202751555 @default.

• next