FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2103569685> ?p ?o ?g. }

• W2103569685 endingPage "819" @default.
• W2103569685 startingPage "813" @default.
• W2103569685 abstract "Serum concentrations of low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), triglycerides (TGs) and total cholesterol (TC) are important heritable risk factors for cardiovascular disease. Although genome-wide association studies (GWASs) of circulating lipid levels have identified numerous loci, a substantial portion of the heritability of these traits remains unexplained. Evidence of unexplained genetic variance can be detected by combining multiple independent markers into additive genetic risk scores. Such polygenic scores, constructed using results from the ENGAGE Consortium GWAS on serum lipids, were applied to predict lipid levels in an independent population-based study, the Rotterdam Study-II (RS-II). We additionally tested for evidence of a shared genetic basis for different lipid phenotypes. Finally, the polygenic score approach was used to identify an alternative genome-wide significance threshold before pathway analysis and those results were compared with those based on the classical genome-wide significance threshold. Our study provides evidence suggesting that many loci influencing circulating lipid levels remain undiscovered. Cross-prediction models suggested a small overlap between the polygenic backgrounds involved in determining LDL-C, HDL-C and TG levels. Pathway analysis utilizing the best polygenic score for TC uncovered extra information compared with using only genome-wide significant loci. These results suggest that the genetic architecture of circulating lipids involves a number of undiscovered variants with very small effects, and that increasing GWAS sample sizes will enable the identification of novel variants that regulate lipid levels." @default.
• W2103569685 created "2016-06-24" @default.
• W2103569685 creator A5001432320 @default.
• W2103569685 creator A5002163035 @default.
• W2103569685 creator A5002275174 @default.
• W2103569685 creator A5003919256 @default.
• W2103569685 creator A5004324001 @default.
• W2103569685 creator A5004664945 @default.
• W2103569685 creator A5007213167 @default.
• W2103569685 creator A5011350655 @default.
• W2103569685 creator A5012652688 @default.
• W2103569685 creator A5013273481 @default.
• W2103569685 creator A5013779874 @default.
• W2103569685 creator A5016275917 @default.
• W2103569685 creator A5017009749 @default.
• W2103569685 creator A5020502354 @default.
• W2103569685 creator A5021807188 @default.
• W2103569685 creator A5022810412 @default.
• W2103569685 creator A5025350717 @default.
• W2103569685 creator A5026632683 @default.
• W2103569685 creator A5031530236 @default.
• W2103569685 creator A5038334172 @default.
• W2103569685 creator A5039611937 @default.
• W2103569685 creator A5040364390 @default.
• W2103569685 creator A5045835301 @default.
• W2103569685 creator A5046641112 @default.
• W2103569685 creator A5047549223 @default.
• W2103569685 creator A5050722566 @default.
• W2103569685 creator A5052290354 @default.
• W2103569685 creator A5055183685 @default.
• W2103569685 creator A5055433188 @default.
• W2103569685 creator A5055747898 @default.
• W2103569685 creator A5057866160 @default.
• W2103569685 creator A5058300698 @default.
• W2103569685 creator A5062871270 @default.
• W2103569685 creator A5064749062 @default.
• W2103569685 creator A5068004396 @default.
• W2103569685 creator A5068037007 @default.
• W2103569685 creator A5069340280 @default.
• W2103569685 creator A5070568170 @default.
• W2103569685 creator A5075624440 @default.
• W2103569685 creator A5076062731 @default.
• W2103569685 creator A5079752137 @default.
• W2103569685 creator A5082019215 @default.
• W2103569685 creator A5085407328 @default.
• W2103569685 creator A5086357825 @default.
• W2103569685 creator A5087949024 @default.
• W2103569685 creator A5089925493 @default.
• W2103569685 date "2011-03-30" @default.
• W2103569685 modified "2023-10-08" @default.
• W2103569685 title "Genetic architecture of circulating lipid levels" @default.
• W2103569685 cites W1973178110 @default.
• W2103569685 cites W1980991473 @default.
• W2103569685 cites W1989115810 @default.
• W2103569685 cites W2004156733 @default.
• W2103569685 cites W2004366492 @default.
• W2103569685 cites W2008479979 @default.
• W2103569685 cites W2015849111 @default.
• W2103569685 cites W2017602185 @default.
• W2103569685 cites W2037252383 @default.
• W2103569685 cites W2037832608 @default.
• W2103569685 cites W2049409070 @default.
• W2103569685 cites W2052992240 @default.
• W2103569685 cites W2060090217 @default.
• W2103569685 cites W2065497963 @default.
• W2103569685 cites W2066200642 @default.
• W2103569685 cites W2068700927 @default.
• W2103569685 cites W2071759640 @default.
• W2103569685 cites W2074644304 @default.
• W2103569685 cites W2090443364 @default.
• W2103569685 cites W2098597355 @default.
• W2103569685 cites W2105281057 @default.
• W2103569685 cites W2109252993 @default.
• W2103569685 cites W2110124859 @default.
• W2103569685 cites W2115801316 @default.
• W2103569685 cites W2116404316 @default.
• W2103569685 cites W2140079333 @default.
• W2103569685 cites W2142642125 @default.
• W2103569685 cites W2142769596 @default.
• W2103569685 cites W2161527180 @default.
• W2103569685 cites W2161633633 @default.
• W2103569685 cites W2163500926 @default.
• W2103569685 cites W2256068727 @default.
• W2103569685 cites W4211231996 @default.
• W2103569685 cites W4243500197 @default.
• W2103569685 doi "https://doi.org/10.1038/ejhg.2011.21" @default.
• W2103569685 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3137496" @default.
• W2103569685 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21448234" @default.
• W2103569685 hasPublicationYear "2011" @default.
• W2103569685 type Work @default.
• W2103569685 sameAs 2103569685 @default.
• W2103569685 citedByCount "20" @default.
• W2103569685 countsByYear W21035696852012 @default.
• W2103569685 countsByYear W21035696852013 @default.
• W2103569685 countsByYear W21035696852014 @default.
• W2103569685 countsByYear W21035696852016 @default.
• W2103569685 countsByYear W21035696852017 @default.
• W2103569685 countsByYear W21035696852018 @default.

• next