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• W2103940281 abstract "A primary function of B lymphocytes is immunoglobulin production; however, the therapeutic benefit of B cell depletion in autoimmune diseases previously thought to be T cell mediated suggests that some B cells fulfill other roles in autoimmunity. We examined the recently identified human B1 cell population for T cell stimulatory activity. We found two kinds of B1 cells that are distinguished by multiple surface markers and distinct transcriptomic profiles. In both umbilical cord and adult peripheral blood, a CD11b+ subset constitutes ∼1 out of every 8–10 B1 cells, whereas a CD11b− subset constitutes the remaining B1 cells. These B1 cell populations differ functionally. CD11b− B1 cells spontaneously secrete much more IgM than CD11b+ B1 cells. In contrast, CD11b+ B1 cells express more CD86, and more efficiently stimulate allogeneic CD4+ T cell expansion, than CD11b− B1 cells. The frequency of these CD11b+ B1 cells is markedly elevated in lupus patients. CD11b+ B1 cells in lupus patients express more CD86 and have increased T cell–stimulating activity in disease. This work distinguishes a novel, T cell–interacting B1 cell population whose abundance and activity may be a reflection of, and a therapeutic target in, autoimmune disease." @default.
• W2103940281 created "2016-06-24" @default.
• W2103940281 creator A5029613699 @default.
• W2103940281 creator A5068331769 @default.
• W2103940281 date "2011-11-21" @default.
• W2103940281 modified "2023-10-11" @default.
• W2103940281 title "A small CD11b+ human B1 cell subpopulation stimulates T cells and is expanded in lupus" @default.
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• W2103940281 doi "https://doi.org/10.1084/jem.20110978" @default.
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