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- W2104076819 abstract "Recombinant human DNase (rhDNase) is a mucolytic agent that is primarily used to improve mucociliary clearance in cystic fibrosis (CF). rhDNase is a recombinant human enzyme that is synthesized in a Chinese hamster ovary cell line. rhDNase enzymatically cleaves extracellular DNA into molecules of shorter length. CF sputum shows high concentrations of DNA released by disintegrating inflammatory cells. Free DNA contributes to the abnormally high viscosity of CF sputum and therefore forms an important target in the treatment of CF lung disease. Clinical studies have shown that daily nebulization of rhDNase is associated with an increase in lung function and a decrease in the frequency of exacerbations in patients with CF." @default.
- W2104076819 created "2016-06-24" @default.
- W2104076819 creator A5079802068 @default.
- W2104076819 creator A5087304691 @default.
- W2104076819 date "2007-12-01" @default.
- W2104076819 modified "2023-09-25" @default.
- W2104076819 title "Pharmacology, clinical efficacy and safety of recombinant human DNase in cystic fibrosis" @default.
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- W2104076819 doi "https://doi.org/10.1586/17476348.1.3.317" @default.
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- W2104076819 hasPublicationYear "2007" @default.
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