Matches in SemOpenAlex for { <https://semopenalex.org/work/W2104916182> ?p ?o ?g. }
- W2104916182 endingPage "8307" @default.
- W2104916182 startingPage "8294" @default.
- W2104916182 abstract "Although previous studies confirmed that steaming and the fermentation process could significantly improve the cognitive-enhancement and neuroprotective effects of Codonopsis lanceolata, the anti-tumor efficacy of steamed C. lanceolata (SCL) and what mechanisms are involved remain largely unknown. The present study was designed to evaluate the anti-tumor effect in vivo of SCL in H22 tumor-bearing mice. The results clearly indicated that SCL could not only inhibit the tumor growth, but also prolong the survival time of H22 tumor-bearing mice. Besides, the serum levels of cytokines, such as interferon gamma (IFN-γ), tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6) and interleukin-2 (IL-2), were enhanced by SCL administration. The observations of Hoechst 33258 staining demonstrated that SCL was able to induce tumor cell apoptosis. Finally, immunohistochemical analysis revealed that SCL treatment significantly increased Bax expression and decreased Bcl-2 and vascular endothelial growth factor (VEGF) expression of H22 tumor tissues in a dose-dependent manner. Moreover, LC/MS analysis of SCL indicated that it mainly contained lobetyolin and six saponins. Taken all together, the findings in the present study clearly demonstrated that SCL inhibited the H22 tumor growth in vivo at least partly via improving the immune functions, inducing apoptosis and inhibiting angiogenesis." @default.
- W2104916182 created "2016-06-24" @default.
- W2104916182 creator A5000432967 @default.
- W2104916182 creator A5017947172 @default.
- W2104916182 creator A5018096486 @default.
- W2104916182 creator A5025033944 @default.
- W2104916182 creator A5028118110 @default.
- W2104916182 creator A5030520798 @default.
- W2104916182 creator A5060002817 @default.
- W2104916182 creator A5065383306 @default.
- W2104916182 date "2015-09-25" @default.
- W2104916182 modified "2023-10-02" @default.
- W2104916182 title "Anti-Tumor Effect of Steamed Codonopsis lanceolata in H22 Tumor-Bearing Mice and Its Possible Mechanism" @default.
- W2104916182 cites W1541764010 @default.
- W2104916182 cites W1964363469 @default.
- W2104916182 cites W1965199244 @default.
- W2104916182 cites W1966239235 @default.
- W2104916182 cites W1968059098 @default.
- W2104916182 cites W1969382600 @default.
- W2104916182 cites W1976417809 @default.
- W2104916182 cites W1982204092 @default.
- W2104916182 cites W1985698341 @default.
- W2104916182 cites W1986085919 @default.
- W2104916182 cites W1990607880 @default.
- W2104916182 cites W2000096662 @default.
- W2104916182 cites W2003779900 @default.
- W2104916182 cites W2010832342 @default.
- W2104916182 cites W2014094023 @default.
- W2104916182 cites W2017344250 @default.
- W2104916182 cites W2019202680 @default.
- W2104916182 cites W2026808212 @default.
- W2104916182 cites W2028879197 @default.
- W2104916182 cites W2033878720 @default.
- W2104916182 cites W2039512150 @default.
- W2104916182 cites W2047229260 @default.
- W2104916182 cites W2048497005 @default.
- W2104916182 cites W2048792306 @default.
- W2104916182 cites W2056446966 @default.
- W2104916182 cites W2060541890 @default.
- W2104916182 cites W2069388139 @default.
- W2104916182 cites W2072410011 @default.
- W2104916182 cites W2073718949 @default.
- W2104916182 cites W2073748539 @default.
- W2104916182 cites W2078835092 @default.
- W2104916182 cites W2081843085 @default.
- W2104916182 cites W2082569453 @default.
- W2104916182 cites W2088937402 @default.
- W2104916182 cites W2089845357 @default.
- W2104916182 cites W2093890115 @default.
- W2104916182 cites W2097786201 @default.
- W2104916182 cites W2100287973 @default.
- W2104916182 cites W2104488113 @default.
- W2104916182 cites W2136172730 @default.
- W2104916182 cites W2140717368 @default.
- W2104916182 cites W2150183586 @default.
- W2104916182 cites W2155674893 @default.
- W2104916182 cites W2165938624 @default.
- W2104916182 cites W2317834952 @default.
- W2104916182 cites W32427749 @default.
- W2104916182 doi "https://doi.org/10.3390/nu7105395" @default.
- W2104916182 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4632415" @default.
- W2104916182 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26426041" @default.
- W2104916182 hasPublicationYear "2015" @default.
- W2104916182 type Work @default.
- W2104916182 sameAs 2104916182 @default.
- W2104916182 citedByCount "45" @default.
- W2104916182 countsByYear W21049161822016 @default.
- W2104916182 countsByYear W21049161822017 @default.
- W2104916182 countsByYear W21049161822018 @default.
- W2104916182 countsByYear W21049161822019 @default.
- W2104916182 countsByYear W21049161822020 @default.
- W2104916182 countsByYear W21049161822021 @default.
- W2104916182 countsByYear W21049161822022 @default.
- W2104916182 countsByYear W21049161822023 @default.
- W2104916182 crossrefType "journal-article" @default.
- W2104916182 hasAuthorship W2104916182A5000432967 @default.
- W2104916182 hasAuthorship W2104916182A5017947172 @default.
- W2104916182 hasAuthorship W2104916182A5018096486 @default.
- W2104916182 hasAuthorship W2104916182A5025033944 @default.
- W2104916182 hasAuthorship W2104916182A5028118110 @default.
- W2104916182 hasAuthorship W2104916182A5030520798 @default.
- W2104916182 hasAuthorship W2104916182A5060002817 @default.
- W2104916182 hasAuthorship W2104916182A5065383306 @default.
- W2104916182 hasBestOaLocation W21049161821 @default.
- W2104916182 hasConcept C150903083 @default.
- W2104916182 hasConcept C167734588 @default.
- W2104916182 hasConcept C17991360 @default.
- W2104916182 hasConcept C190283241 @default.
- W2104916182 hasConcept C203014093 @default.
- W2104916182 hasConcept C204232928 @default.
- W2104916182 hasConcept C207001950 @default.
- W2104916182 hasConcept C25498285 @default.
- W2104916182 hasConcept C2777025900 @default.
- W2104916182 hasConcept C2778690821 @default.
- W2104916182 hasConcept C2780394083 @default.
- W2104916182 hasConcept C502942594 @default.
- W2104916182 hasConcept C55493867 @default.
- W2104916182 hasConcept C62112901 @default.