FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2105725772> ?p ?o ?g. }

• W2105725772 endingPage "17997" @default.
• W2105725772 startingPage "17988" @default.
• W2105725772 abstract "Climbing fiber (CF) input to the cerebellum is thought to instruct associative motor memory formation through its effects on multiple sites within the cerebellar circuit. We used adeno-associated viral delivery of channelrhodopsin-2 (ChR2) to inferior olivary neurons to selectively express ChR2 in CFs, achieving nearly complete transfection of CFs in the caudal cerebellar lobules of rats. As expected, optical stimulation of ChR2-expressing CFs generates complex spike responses in individual Purkinje neurons (PNs); in addition we found that such stimulation recruits a network of inhibitory interneurons in the molecular layer. This CF-driven disynaptic inhibition prolongs the postcomplex spike pause observed when spontaneously firing PNs receive direct CF input; such inhibition also elicits pauses in spontaneously firing PNs not receiving direct CF input. Baseline firing rates of PNs are strongly suppressed by low-frequency (2 Hz) stimulation of CFs, and this suppression is partly relieved by blocking synaptic inhibition. We conclude that CF-driven, disynaptic inhibition has a major influence on PN excitability and contributes to the widely observed negative correlation between complex and simple spike rates. Because they receive input from many CFs, molecular layer interneurons are well positioned to detect the spatiotemporal patterns of CF activity believed to encode error signals. Together, our findings suggest that such inhibition may bind together groups of Purkinje neurons to provide instructive signals to downstream sites in the cerebellar circuit." @default.
• W2105725772 created "2016-06-24" @default.
• W2105725772 creator A5003372884 @default.
• W2105725772 creator A5050162581 @default.
• W2105725772 creator A5061089065 @default.
• W2105725772 creator A5063851005 @default.
• W2105725772 creator A5073764338 @default.
• W2105725772 date "2012-12-12" @default.
• W2105725772 modified "2023-10-18" @default.
• W2105725772 title "Effects of Climbing Fiber Driven Inhibition on Purkinje Neuron Spiking" @default.
• W2105725772 cites W128802464 @default.
• W2105725772 cites W1965741585 @default.
• W2105725772 cites W1967106621 @default.
• W2105725772 cites W1967314223 @default.
• W2105725772 cites W1969650326 @default.
• W2105725772 cites W1970495875 @default.
• W2105725772 cites W1974705877 @default.
• W2105725772 cites W1984601572 @default.
• W2105725772 cites W1986870707 @default.
• W2105725772 cites W1987507775 @default.
• W2105725772 cites W1990187533 @default.
• W2105725772 cites W1990235702 @default.
• W2105725772 cites W1995360097 @default.
• W2105725772 cites W2019640859 @default.
• W2105725772 cites W2020030874 @default.
• W2105725772 cites W2020317154 @default.
• W2105725772 cites W2021789384 @default.
• W2105725772 cites W2022240149 @default.
• W2105725772 cites W2023095581 @default.
• W2105725772 cites W2025432774 @default.
• W2105725772 cites W2034719331 @default.
• W2105725772 cites W2047758880 @default.
• W2105725772 cites W2052280289 @default.
• W2105725772 cites W2053125449 @default.
• W2105725772 cites W2055850746 @default.
• W2105725772 cites W2060580046 @default.
• W2105725772 cites W2061643993 @default.
• W2105725772 cites W2068456043 @default.
• W2105725772 cites W2077374589 @default.
• W2105725772 cites W2079502754 @default.
• W2105725772 cites W2080886381 @default.
• W2105725772 cites W2093092087 @default.
• W2105725772 cites W2097105997 @default.
• W2105725772 cites W2103019454 @default.
• W2105725772 cites W2112465764 @default.
• W2105725772 cites W2115987813 @default.
• W2105725772 cites W2117551534 @default.
• W2105725772 cites W2117602610 @default.
• W2105725772 cites W2117908157 @default.
• W2105725772 cites W2129212414 @default.
• W2105725772 cites W2131921751 @default.
• W2105725772 cites W2133544641 @default.
• W2105725772 cites W2135887863 @default.
• W2105725772 cites W2139883529 @default.
• W2105725772 cites W2155051950 @default.
• W2105725772 cites W2261672728 @default.
• W2105725772 cites W4214868137 @default.
• W2105725772 cites W47332291 @default.
• W2105725772 cites W83493096 @default.
• W2105725772 doi "https://doi.org/10.1523/jneurosci.3916-12.2012" @default.
• W2105725772 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3532857" @default.
• W2105725772 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23238715" @default.
• W2105725772 hasPublicationYear "2012" @default.
• W2105725772 type Work @default.
• W2105725772 sameAs 2105725772 @default.
• W2105725772 citedByCount "80" @default.
• W2105725772 countsByYear W21057257722012 @default.
• W2105725772 countsByYear W21057257722013 @default.
• W2105725772 countsByYear W21057257722014 @default.
• W2105725772 countsByYear W21057257722015 @default.
• W2105725772 countsByYear W21057257722016 @default.
• W2105725772 countsByYear W21057257722017 @default.
• W2105725772 countsByYear W21057257722018 @default.
• W2105725772 countsByYear W21057257722019 @default.
• W2105725772 countsByYear W21057257722020 @default.
• W2105725772 countsByYear W21057257722021 @default.
• W2105725772 countsByYear W21057257722022 @default.
• W2105725772 countsByYear W21057257722023 @default.
• W2105725772 crossrefType "journal-article" @default.
• W2105725772 hasAuthorship W2105725772A5003372884 @default.
• W2105725772 hasAuthorship W2105725772A5050162581 @default.
• W2105725772 hasAuthorship W2105725772A5061089065 @default.
• W2105725772 hasAuthorship W2105725772A5063851005 @default.
• W2105725772 hasAuthorship W2105725772A5073764338 @default.
• W2105725772 hasBestOaLocation W21057257721 @default.
• W2105725772 hasConcept C112592302 @default.
• W2105725772 hasConcept C169760540 @default.
• W2105725772 hasConcept C17077164 @default.
• W2105725772 hasConcept C185592680 @default.
• W2105725772 hasConcept C24998067 @default.
• W2105725772 hasConcept C2778058767 @default.
• W2105725772 hasConcept C2778472085 @default.
• W2105725772 hasConcept C2779652256 @default.
• W2105725772 hasConcept C2780393176 @default.
• W2105725772 hasConcept C2993045875 @default.
• W2105725772 hasConcept C50738837 @default.
• W2105725772 hasConcept C86803240 @default.
• W2105725772 hasConceptScore W2105725772C112592302 @default.

• next