Matches in SemOpenAlex for { <https://semopenalex.org/work/W2106570133> ?p ?o ?g. }
- W2106570133 endingPage "744" @default.
- W2106570133 startingPage "729" @default.
- W2106570133 abstract "The migration of cortical interneurons is characterized by extensive morphological changes that result from successive cycles of nucleokinesis and neurite branching. Their molecular bases remain elusive, and the present work describes how p27Kip1 controls cell-cycle-unrelated signaling pathways to regulate these morphological remodelings. Live imaging reveals that interneurons lacking p27Kip1 show delayed tangential migration resulting from defects in both nucleokinesis and dynamic branching of the leading process. At the molecular level, p27Kip1 is a microtubule-associated protein that promotes polymerization of microtubules in extending neurites, thereby contributing to tangential migration. Furthermore, we show that p27Kip1 controls actomyosin contractions that drive both forward translocation of the nucleus and growth cone splitting. Thus, p27Kip1 cell-autonomously controls nucleokinesis and neurite branching by regulating both actin and microtubule cytoskeletons." @default.
- W2106570133 created "2016-06-24" @default.
- W2106570133 creator A5005768612 @default.
- W2106570133 creator A5022727340 @default.
- W2106570133 creator A5026501889 @default.
- W2106570133 creator A5028709583 @default.
- W2106570133 creator A5029427610 @default.
- W2106570133 creator A5030325551 @default.
- W2106570133 creator A5047910105 @default.
- W2106570133 creator A5051558425 @default.
- W2106570133 creator A5056950349 @default.
- W2106570133 creator A5057341523 @default.
- W2106570133 creator A5061600171 @default.
- W2106570133 creator A5063268283 @default.
- W2106570133 creator A5065746899 @default.
- W2106570133 creator A5074345717 @default.
- W2106570133 creator A5078000054 @default.
- W2106570133 creator A5089388020 @default.
- W2106570133 date "2012-10-01" @default.
- W2106570133 modified "2023-10-18" @default.
- W2106570133 title "p27Kip1 Is a Microtubule-Associated Protein that Promotes Microtubule Polymerization during Neuron Migration" @default.
- W2106570133 cites W1485573785 @default.
- W2106570133 cites W1896987527 @default.
- W2106570133 cites W1971305731 @default.
- W2106570133 cites W1974574293 @default.
- W2106570133 cites W1983052853 @default.
- W2106570133 cites W1992125801 @default.
- W2106570133 cites W1992869573 @default.
- W2106570133 cites W1997087774 @default.
- W2106570133 cites W2006628753 @default.
- W2106570133 cites W2024993320 @default.
- W2106570133 cites W2026004604 @default.
- W2106570133 cites W2032295238 @default.
- W2106570133 cites W2033324702 @default.
- W2106570133 cites W2033349885 @default.
- W2106570133 cites W2034924067 @default.
- W2106570133 cites W2058549524 @default.
- W2106570133 cites W2062115002 @default.
- W2106570133 cites W2063377436 @default.
- W2106570133 cites W2066408517 @default.
- W2106570133 cites W2069657766 @default.
- W2106570133 cites W2073500884 @default.
- W2106570133 cites W2074741279 @default.
- W2106570133 cites W2080893376 @default.
- W2106570133 cites W2085655013 @default.
- W2106570133 cites W2090937576 @default.
- W2106570133 cites W2092667485 @default.
- W2106570133 cites W2093225683 @default.
- W2106570133 cites W2093621223 @default.
- W2106570133 cites W2094228287 @default.
- W2106570133 cites W2100173413 @default.
- W2106570133 cites W2106675234 @default.
- W2106570133 cites W2107806372 @default.
- W2106570133 cites W2110681613 @default.
- W2106570133 cites W2113144687 @default.
- W2106570133 cites W2115279938 @default.
- W2106570133 cites W2116711648 @default.
- W2106570133 cites W2119459951 @default.
- W2106570133 cites W2125842400 @default.
- W2106570133 cites W2139829576 @default.
- W2106570133 cites W2140536312 @default.
- W2106570133 cites W2141352824 @default.
- W2106570133 cites W2150102283 @default.
- W2106570133 cites W2157001435 @default.
- W2106570133 cites W2161135924 @default.
- W2106570133 cites W2163380380 @default.
- W2106570133 cites W2165097825 @default.
- W2106570133 cites W2167463357 @default.
- W2106570133 cites W2170024216 @default.
- W2106570133 doi "https://doi.org/10.1016/j.devcel.2012.08.006" @default.
- W2106570133 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23022035" @default.
- W2106570133 hasPublicationYear "2012" @default.
- W2106570133 type Work @default.
- W2106570133 sameAs 2106570133 @default.
- W2106570133 citedByCount "94" @default.
- W2106570133 countsByYear W21065701332013 @default.
- W2106570133 countsByYear W21065701332014 @default.
- W2106570133 countsByYear W21065701332015 @default.
- W2106570133 countsByYear W21065701332016 @default.
- W2106570133 countsByYear W21065701332017 @default.
- W2106570133 countsByYear W21065701332018 @default.
- W2106570133 countsByYear W21065701332019 @default.
- W2106570133 countsByYear W21065701332020 @default.
- W2106570133 countsByYear W21065701332021 @default.
- W2106570133 countsByYear W21065701332022 @default.
- W2106570133 countsByYear W21065701332023 @default.
- W2106570133 crossrefType "journal-article" @default.
- W2106570133 hasAuthorship W2106570133A5005768612 @default.
- W2106570133 hasAuthorship W2106570133A5022727340 @default.
- W2106570133 hasAuthorship W2106570133A5026501889 @default.
- W2106570133 hasAuthorship W2106570133A5028709583 @default.
- W2106570133 hasAuthorship W2106570133A5029427610 @default.
- W2106570133 hasAuthorship W2106570133A5030325551 @default.
- W2106570133 hasAuthorship W2106570133A5047910105 @default.
- W2106570133 hasAuthorship W2106570133A5051558425 @default.
- W2106570133 hasAuthorship W2106570133A5056950349 @default.
- W2106570133 hasAuthorship W2106570133A5057341523 @default.
- W2106570133 hasAuthorship W2106570133A5061600171 @default.