FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2108148246> ?p ?o ?g. }

• W2108148246 endingPage "9483" @default.
• W2108148246 startingPage "9471" @default.
• W2108148246 abstract "Expression of the complete HIV-1 genome depends on the appropriate processing of viral RNA. Altering the balance of viral RNA processing impairs replication of the virus. In this report, we characterize two small molecule modulators of HIV-1 RNA processing, 8-azaguanine and 2-(2-(5-nitro-2-thienyl)vinyl)quinoline (5350150), which function by distinct mechanisms to suppress viral gene expression. Although only 8-Azaguanine dramatically decreased accumulation of HIV-1 unspliced and singly spliced RNAs and altered splice site usage, both compounds blocked Gag and Env expression without affecting production of Tat (p16) and Rev regulatory proteins. Subsequent analyses suggest that these compounds affect Rev-mediated RNA transport by different mechanisms. Both compounds induced cytoplasmic accumulation of Rev, suggesting that they function, in part, by impairing Rev function. This conclusion is supported by the determination that both drugs block the nuclear export of genomic HIV-1 RNA to the cytoplasm. Testing confirmed that these compounds suppress HIV-1 expression in T cells at doses below those previously used in humans for tumour chemotherapy. Together, our observations demonstrate that small molecules can be used to inhibit HIV-1 replication by altering another avenue of viral RNA processing, offering the potential for the development of novel therapeutics for controlling this disease." @default.
• W2108148246 created "2016-06-24" @default.
• W2108148246 creator A5025697366 @default.
• W2108148246 creator A5027323052 @default.
• W2108148246 creator A5039201976 @default.
• W2108148246 creator A5044918402 @default.
• W2108148246 creator A5065256408 @default.
• W2108148246 date "2013-08-13" @default.
• W2108148246 modified "2023-10-17" @default.
• W2108148246 title "Characterization of novel inhibitors of HIV-1 replication that function via alteration of viral RNA processing and rev function" @default.
• W2108148246 cites W1505075418 @default.
• W2108148246 cites W1514727870 @default.
• W2108148246 cites W1576538493 @default.
• W2108148246 cites W1591518654 @default.
• W2108148246 cites W1840089255 @default.
• W2108148246 cites W1880169023 @default.
• W2108148246 cites W1968339979 @default.
• W2108148246 cites W1980474989 @default.
• W2108148246 cites W2001163291 @default.
• W2108148246 cites W2025508015 @default.
• W2108148246 cites W2025634036 @default.
• W2108148246 cites W2029292460 @default.
• W2108148246 cites W2031991206 @default.
• W2108148246 cites W2032785100 @default.
• W2108148246 cites W2033572660 @default.
• W2108148246 cites W2034852103 @default.
• W2108148246 cites W2044293862 @default.
• W2108148246 cites W2045186821 @default.
• W2108148246 cites W2048897812 @default.
• W2108148246 cites W2052135311 @default.
• W2108148246 cites W2060465438 @default.
• W2108148246 cites W2060501930 @default.
• W2108148246 cites W2065405155 @default.
• W2108148246 cites W2073043894 @default.
• W2108148246 cites W2078221753 @default.
• W2108148246 cites W2080667453 @default.
• W2108148246 cites W2080914608 @default.
• W2108148246 cites W2083340704 @default.
• W2108148246 cites W2086783015 @default.
• W2108148246 cites W2105821747 @default.
• W2108148246 cites W2106863691 @default.
• W2108148246 cites W2116893683 @default.
• W2108148246 cites W2119539161 @default.
• W2108148246 cites W2130048636 @default.
• W2108148246 cites W2138647063 @default.
• W2108148246 cites W2140633605 @default.
• W2108148246 cites W2143408079 @default.
• W2108148246 cites W2170463669 @default.
• W2108148246 cites W2171305498 @default.
• W2108148246 cites W2441854741 @default.
• W2108148246 cites W8125474 @default.
• W2108148246 doi "https://doi.org/10.1093/nar/gkt727" @default.
• W2108148246 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3814367" @default.
• W2108148246 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23945945" @default.
• W2108148246 hasPublicationYear "2013" @default.
• W2108148246 type Work @default.
• W2108148246 sameAs 2108148246 @default.
• W2108148246 citedByCount "29" @default.
• W2108148246 countsByYear W21081482462014 @default.
• W2108148246 countsByYear W21081482462016 @default.
• W2108148246 countsByYear W21081482462017 @default.
• W2108148246 countsByYear W21081482462018 @default.
• W2108148246 countsByYear W21081482462019 @default.
• W2108148246 countsByYear W21081482462020 @default.
• W2108148246 countsByYear W21081482462021 @default.
• W2108148246 countsByYear W21081482462022 @default.
• W2108148246 countsByYear W21081482462023 @default.
• W2108148246 crossrefType "journal-article" @default.
• W2108148246 hasAuthorship W2108148246A5025697366 @default.
• W2108148246 hasAuthorship W2108148246A5027323052 @default.
• W2108148246 hasAuthorship W2108148246A5039201976 @default.
• W2108148246 hasAuthorship W2108148246A5044918402 @default.
• W2108148246 hasAuthorship W2108148246A5065256408 @default.
• W2108148246 hasBestOaLocation W21081482461 @default.
• W2108148246 hasConcept C104317684 @default.
• W2108148246 hasConcept C14036430 @default.
• W2108148246 hasConcept C140704245 @default.
• W2108148246 hasConcept C150194340 @default.
• W2108148246 hasConcept C159047783 @default.
• W2108148246 hasConcept C2522874641 @default.
• W2108148246 hasConcept C54355233 @default.
• W2108148246 hasConcept C54458228 @default.
• W2108148246 hasConcept C67705224 @default.
• W2108148246 hasConcept C86803240 @default.
• W2108148246 hasConcept C95444343 @default.
• W2108148246 hasConceptScore W2108148246C104317684 @default.
• W2108148246 hasConceptScore W2108148246C14036430 @default.
• W2108148246 hasConceptScore W2108148246C140704245 @default.
• W2108148246 hasConceptScore W2108148246C150194340 @default.
• W2108148246 hasConceptScore W2108148246C159047783 @default.
• W2108148246 hasConceptScore W2108148246C2522874641 @default.
• W2108148246 hasConceptScore W2108148246C54355233 @default.
• W2108148246 hasConceptScore W2108148246C54458228 @default.
• W2108148246 hasConceptScore W2108148246C67705224 @default.
• W2108148246 hasConceptScore W2108148246C86803240 @default.
• W2108148246 hasConceptScore W2108148246C95444343 @default.
• W2108148246 hasIssue "20" @default.
• W2108148246 hasLocation W21081482461 @default.

• next