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• W2108284151 abstract "We show that microRNA-427 (miR-427) mediates the rapid deadenylation of maternal mRNAs after the midblastula transition (MBT) of Xenopus laevis embryogenesis. By MBT, the stage when the embryonic cell cycle is remodeled and zygotic transcription of mRNAs is initiated, each embryo has accumulated ∼10 9 molecules of miR-427 processed from multimeric pri-miR-427 transcripts synthesized after fertilization. We demonstrate that the maternal mRNAs for cyclins A1 and B2 each contain a single miR-427 target sequence, spanning less than 30 nucleotides, that is both necessary and sufficient for deadenylation, and that inactivation of miR-427 leads to stabilization of the mRNAs. Although this deadenylation normally takes place after MBT, exogenous miRNAs produced prematurely in vivo can promote deadenylation prior to MBT, indicating that turnover of the maternal mRNAs is limited by the amount of accumulated miR-427. Injected transcripts comprised solely of the cyclin mRNA 3′ untranslated regions or bearing a 5′ ApppG cap undergo deadenylation, showing that translation of the targeted RNA is not required. miR-427 is not unique in promoting deadenylation, as an unrelated miRNA, let-7, can substitute for miR-427 if the reporter RNA contains an appropriate let-7 target site. We propose that miR-427, like the orthologous miR-430 of zebrafish, functions to down-regulate expression of maternal mRNAs early in development." @default.
• W2108284151 created "2016-06-24" @default.
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• W2108284151 creator A5051062987 @default.
• W2108284151 creator A5058815116 @default.
• W2108284151 date "2009-10-23" @default.
• W2108284151 modified "2023-10-16" @default.
• W2108284151 title "Deadenylation of maternal mRNAs mediated by miR-427 in <i>Xenopus laevis</i> embryos" @default.
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• W2108284151 doi "https://doi.org/10.1261/rna.1882009" @default.
• W2108284151 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2779678" @default.
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