FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2108529527> ?p ?o ?g. }

• W2108529527 endingPage "3053" @default.
• W2108529527 startingPage "3045" @default.
• W2108529527 abstract "Accumulated evidence links an important signal involved in glucose-stimulated insulin release to the activation of the islet lysosomal glycogenolytic enzyme acid glucan-1,4-α-glucosidase. We have analyzed the function of the lysosomal system/lysosomal enzyme activities in pancreatic islets of young (6–8 weeks), spontaneously diabetic, GK (Goto-Kakizaki) rats and Wistar control rats in relation to glucose-induced insulin release. The insulin secretory response to glucose was markedly impaired in the GK rat, but was restored by the adenylate cyclase activator forskolin. Islet activities of classical lysosomal enzymes, e.g.. acid phosphatase, N-acetyl-β-d-glucosaminidase,β -glucuronidase, and cathepsin D, were reduced by 20–35% in the GK rat compared with those in Wistar controls. In contrast, the activities of the lysosomal α-glucosidehydrolases, i.e.. acid glucan-1,4-α-glucosidase and acid α-glucosidase, were increased by 40–50%. Neutral α-glucosidase (endoplasmic reticulum) was unaffected. Comparative analysis of liver tissue showed that lysosomal enzyme activities were of the same magnitude in GK and Wistar rats. Notably, in Wistar rats, the activities of acid glucan-1,4-α-glucosidase and acid α-glucosidase were approximately 15-fold higher in islets than in liver. Other lysosomal enzymes did not display such a difference. Normalization of glycemia in GK rats by phlorizin administered for 9 days did not influence either the lysosomal α-glucosidehydrolase activities or other lysosomal enzyme activities in GK islets. Finally, the pseudotetrasaccharide acarbose, which accumulates in the lysosomal system, inhibited acid glucan-1,4-α-glucosidase activity in parallel with its inhibitory action on glucose-induced insulin release in intact Wistar islets, whereas no effect was recorded for either parameter in intact GK islets. In contrast, acarbose inhibited the enzyme activity equally in islet homogenates from both GK and Wistar rats, showing that the catalytic activity of the enzyme itself in disrupted cells was unaffected. We propose that dysfunction of the islet lysosomal/vacuolar system is an important defect impairing the transduction mechanisms for glucose-induced insulin release in the GK rat." @default.
• W2108529527 created "2016-06-24" @default.
• W2108529527 creator A5002310756 @default.
• W2108529527 creator A5003637007 @default.
• W2108529527 creator A5008809409 @default.
• W2108529527 creator A5009905641 @default.
• W2108529527 creator A5036673654 @default.
• W2108529527 creator A5042723115 @default.
• W2108529527 date "1999-07-01" @default.
• W2108529527 modified "2023-10-17" @default.
• W2108529527 title "Dysfunction of the Islet Lysosomal System Conveys Impairment of Glucose-Induced Insulin Release in the Diabetic GK Rat*" @default.
• W2108529527 cites W10640494 @default.
• W2108529527 cites W111885494 @default.
• W2108529527 cites W1775749144 @default.
• W2108529527 cites W1965002200 @default.
• W2108529527 cites W1983367679 @default.
• W2108529527 cites W1983991331 @default.
• W2108529527 cites W1985938279 @default.
• W2108529527 cites W1997010909 @default.
• W2108529527 cites W2014502385 @default.
• W2108529527 cites W2016248443 @default.
• W2108529527 cites W2016685642 @default.
• W2108529527 cites W2032306517 @default.
• W2108529527 cites W2037526856 @default.
• W2108529527 cites W2039379650 @default.
• W2108529527 cites W2040889233 @default.
• W2108529527 cites W2072577318 @default.
• W2108529527 cites W2075773439 @default.
• W2108529527 cites W2077375633 @default.
• W2108529527 cites W2080484067 @default.
• W2108529527 cites W2085196897 @default.
• W2108529527 cites W2087402016 @default.
• W2108529527 cites W2088022780 @default.
• W2108529527 cites W2089866099 @default.
• W2108529527 cites W2092581818 @default.
• W2108529527 cites W2135167763 @default.
• W2108529527 cites W2149461974 @default.
• W2108529527 cites W2155085285 @default.
• W2108529527 cites W2218148748 @default.
• W2108529527 cites W2407838333 @default.
• W2108529527 cites W2426227166 @default.
• W2108529527 cites W2472851785 @default.
• W2108529527 cites W4320300859 @default.
• W2108529527 doi "https://doi.org/10.1210/endo.140.7.6862" @default.
• W2108529527 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28200714" @default.
• W2108529527 hasPublicationYear "1999" @default.
• W2108529527 type Work @default.
• W2108529527 sameAs 2108529527 @default.
• W2108529527 citedByCount "37" @default.
• W2108529527 countsByYear W21085295272012 @default.
• W2108529527 countsByYear W21085295272013 @default.
• W2108529527 countsByYear W21085295272014 @default.
• W2108529527 countsByYear W21085295272015 @default.
• W2108529527 countsByYear W21085295272017 @default.
• W2108529527 countsByYear W21085295272020 @default.
• W2108529527 crossrefType "journal-article" @default.
• W2108529527 hasAuthorship W2108529527A5002310756 @default.
• W2108529527 hasAuthorship W2108529527A5003637007 @default.
• W2108529527 hasAuthorship W2108529527A5008809409 @default.
• W2108529527 hasAuthorship W2108529527A5009905641 @default.
• W2108529527 hasAuthorship W2108529527A5036673654 @default.
• W2108529527 hasAuthorship W2108529527A5042723115 @default.
• W2108529527 hasBestOaLocation W21085295271 @default.
• W2108529527 hasConcept C126322002 @default.
• W2108529527 hasConcept C134018914 @default.
• W2108529527 hasConcept C165220095 @default.
• W2108529527 hasConcept C181199279 @default.
• W2108529527 hasConcept C185592680 @default.
• W2108529527 hasConcept C21547065 @default.
• W2108529527 hasConcept C2779306644 @default.
• W2108529527 hasConcept C2780216420 @default.
• W2108529527 hasConcept C55493867 @default.
• W2108529527 hasConcept C71924100 @default.
• W2108529527 hasConcept C86803240 @default.
• W2108529527 hasConceptScore W2108529527C126322002 @default.
• W2108529527 hasConceptScore W2108529527C134018914 @default.
• W2108529527 hasConceptScore W2108529527C165220095 @default.
• W2108529527 hasConceptScore W2108529527C181199279 @default.
• W2108529527 hasConceptScore W2108529527C185592680 @default.
• W2108529527 hasConceptScore W2108529527C21547065 @default.
• W2108529527 hasConceptScore W2108529527C2779306644 @default.
• W2108529527 hasConceptScore W2108529527C2780216420 @default.
• W2108529527 hasConceptScore W2108529527C55493867 @default.
• W2108529527 hasConceptScore W2108529527C71924100 @default.
• W2108529527 hasConceptScore W2108529527C86803240 @default.
• W2108529527 hasIssue "7" @default.
• W2108529527 hasLocation W21085295271 @default.
• W2108529527 hasLocation W21085295272 @default.
• W2108529527 hasOpenAccess W2108529527 @default.
• W2108529527 hasPrimaryLocation W21085295271 @default.
• W2108529527 hasRelatedWork W148975924 @default.
• W2108529527 hasRelatedWork W1989482054 @default.
• W2108529527 hasRelatedWork W2000203143 @default.
• W2108529527 hasRelatedWork W2024722390 @default.
• W2108529527 hasRelatedWork W2043447721 @default.
• W2108529527 hasRelatedWork W2132474791 @default.
• W2108529527 hasRelatedWork W2159041752 @default.
• W2108529527 hasRelatedWork W2394142400 @default.

• next