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- W2110770791 abstract "This brief review focuses on the genetic contribution to childhood obesity. Evidence for a genetic component to excess body weight during growth is presented from the perspective of genetic epidemiology studies. Parental obesity is a predictor of childhood excess weight. The familial risk ratio for childhood obesity when a parent is obese reaches >2.5. Birth weight is characterized by a genetic heritability component on the order of 30%, with significant maternal and paternal effects in addition to the newborn genes. About 5% of childhood obesity cases are caused by a defect that impairs function in a gene, and ≥5 of these genes have been uncovered. However, the common forms of childhood obesity seem to result from a predisposition that primarily favors obesogenic behaviors in an obesogenic environment. Candidate gene and genomewide association studies reveal that these obesogenic genes have small effect sizes but that the risk alleles for obesity are quite common in populations. The latter may translate into a highly significant population-attributable risk of obesity. Gene-environment interaction studies suggest that the effects of predisposing genes can be enhanced or diminished by exposure to relevant behaviors. It is possible that the prevalence of childhood obesity is increasing across generations as a result of positive assortative mating with obese husbands and wives contributing more obese offspring than normal-weight parents." @default.
- W2110770791 created "2016-06-24" @default.
- W2110770791 creator A5060568681 @default.
- W2110770791 date "2009-05-01" @default.
- W2110770791 modified "2023-10-16" @default.
- W2110770791 title "Childhood obesity: are genetic differences involved?" @default.
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- W2110770791 doi "https://doi.org/10.3945/ajcn.2009.27113c" @default.
- W2110770791 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2677002" @default.
- W2110770791 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19261728" @default.
- W2110770791 hasPublicationYear "2009" @default.
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