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• W2114512918 abstract "Pyrimethamine efficacy was investigated in vitro on the blood asexual stages, the sexual stages and exflagellation in PlasmodiumJalciparum. Gametocytogenesis was stimulated following the standard methods on five isolates of Plasmodium Jalciparum. From these five isolates, RSA 2, 3 and 5 produced gametocytes which reached maturity within seven days and the gametocytes were able to exflagellate. Isolate MW2 produced young gametocytes which disappeared within ten days. NF54 produced mature gametocytes which lasted for 24 hours only. There were no statistically significant differences between the static and the synchronization methods of gametocyte stimulation for any of the isolates. The effect of pyrimethamine was investigated by adding a known concentration of the drug (For RSA 2, MW2 and NF54, lOOnmolli; RSA 3 and 5, 3000nmolli pyrimethamine) to the culture medium for seven days during gametocyte stimulation. The results of this investigation show that there was gametocytocidal activity on the isolates that were used and pyrimethamine also had a schizontocidal action on NF54 and the young gametocytes of this isolate were destroyed by the drug. At concentrations which were inhibitory to asexual parasites, the drug had a sporontocidal effect on isolate RSA 2 but not on isolate RSA 5. The pyrimethamine MIC values for asexual parasites ranged from 300nmoll i to > 3000nmol/ i (RSA 2 and 5 were not inhibited at 3 OOOn mol/ f). These results are consistent with those found in previous studies when pyrimethamine resistance was first detected in South Africa." @default.
• W2114512918 created "2016-06-24" @default.
• W2114512918 creator A5044772911 @default.
• W2114512918 date "1995-01-01" @default.
• W2114512918 modified "2023-09-27" @default.
• W2114512918 title "Effect of pyrimethamine on gametocytogenesis, exflagellation and asexual growth in southern African isolates of Plasmodium Falciparum." @default.
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