Matches in SemOpenAlex for { <https://semopenalex.org/work/W2114667085> ?p ?o ?g. }
- W2114667085 endingPage "NA" @default.
- W2114667085 startingPage "NA" @default.
- W2114667085 abstract "Acetaminophen-induced liver injury (AILI) is a significant health problem and represents the most frequent cause of drug-induced liver failure in the United States. The development and implementation of successful therapeutic intervention strategies have been demanding, due to significant limitations associated with the current treatment for AILI. Lactoferrin (Lac), a glycoprotein present in milk, has been demonstrated to possess a multitude of biological functions. Our study demonstrated a profound protective effect of Lac in a murine model of AILI, which was not dependent on its iron-binding ability, inhibition of acetaminophen (APAP) metabolism, or a direct cytoprotective effect on hepatocytes. Instead, Lac treatment significantly attenuated APAP-induced liver sinusoidal endothelial cell dysfunction and ameliorated hepatic microcirculation disorder. This protective effect of Lac appeared to be dependent on hepatic resident macrophages (Kupffer cells [KCs]). Conclusion: Collectively, our data indicate that Lac, through activation of KCs, inhibited APAP-induced liver sinusoidal endothelial cell damage and improved hepatic congestion, thereby protecting against AILI. These findings reveal the significant therapeutic potential of Lac during AILI and other types of liver diseases. (HEPATOLOGY 2010.)" @default.
- W2114667085 created "2016-06-24" @default.
- W2114667085 creator A5008566785 @default.
- W2114667085 creator A5016907321 @default.
- W2114667085 creator A5040757935 @default.
- W2114667085 creator A5071506976 @default.
- W2114667085 creator A5075382072 @default.
- W2114667085 creator A5089703861 @default.
- W2114667085 date "2010-01-01" @default.
- W2114667085 modified "2023-09-27" @default.
- W2114667085 title "Lactoferrin protects against acetaminophen-induced liver injury in mice" @default.
- W2114667085 cites W1252703846 @default.
- W2114667085 cites W1510296527 @default.
- W2114667085 cites W1968671797 @default.
- W2114667085 cites W1983941708 @default.
- W2114667085 cites W1986107319 @default.
- W2114667085 cites W1991621876 @default.
- W2114667085 cites W1991729084 @default.
- W2114667085 cites W1994275881 @default.
- W2114667085 cites W1997325736 @default.
- W2114667085 cites W2000115962 @default.
- W2114667085 cites W2006574959 @default.
- W2114667085 cites W2018268831 @default.
- W2114667085 cites W2025344040 @default.
- W2114667085 cites W2029336962 @default.
- W2114667085 cites W2029343225 @default.
- W2114667085 cites W2031381742 @default.
- W2114667085 cites W2059726461 @default.
- W2114667085 cites W2061763404 @default.
- W2114667085 cites W2067578723 @default.
- W2114667085 cites W2069585529 @default.
- W2114667085 cites W2078036072 @default.
- W2114667085 cites W2078168582 @default.
- W2114667085 cites W2099035168 @default.
- W2114667085 cites W2104425098 @default.
- W2114667085 cites W2108290804 @default.
- W2114667085 cites W2119749845 @default.
- W2114667085 cites W2119900141 @default.
- W2114667085 cites W2124503827 @default.
- W2114667085 cites W2125362990 @default.
- W2114667085 cites W2145147082 @default.
- W2114667085 cites W2151930658 @default.
- W2114667085 cites W2153940277 @default.
- W2114667085 cites W2154321074 @default.
- W2114667085 cites W2158710625 @default.
- W2114667085 cites W2163790438 @default.
- W2114667085 cites W2164685578 @default.
- W2114667085 cites W4231784681 @default.
- W2114667085 cites W4240962591 @default.
- W2114667085 cites W7512181 @default.
- W2114667085 doi "https://doi.org/10.1002/hep.23476" @default.
- W2114667085 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2908515" @default.
- W2114667085 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20099297" @default.
- W2114667085 hasPublicationYear "2010" @default.
- W2114667085 type Work @default.
- W2114667085 sameAs 2114667085 @default.
- W2114667085 citedByCount "36" @default.
- W2114667085 countsByYear W21146670852013 @default.
- W2114667085 countsByYear W21146670852014 @default.
- W2114667085 countsByYear W21146670852015 @default.
- W2114667085 countsByYear W21146670852016 @default.
- W2114667085 countsByYear W21146670852017 @default.
- W2114667085 countsByYear W21146670852018 @default.
- W2114667085 countsByYear W21146670852019 @default.
- W2114667085 countsByYear W21146670852020 @default.
- W2114667085 countsByYear W21146670852021 @default.
- W2114667085 countsByYear W21146670852022 @default.
- W2114667085 countsByYear W21146670852023 @default.
- W2114667085 crossrefType "journal-article" @default.
- W2114667085 hasAuthorship W2114667085A5008566785 @default.
- W2114667085 hasAuthorship W2114667085A5016907321 @default.
- W2114667085 hasAuthorship W2114667085A5040757935 @default.
- W2114667085 hasAuthorship W2114667085A5071506976 @default.
- W2114667085 hasAuthorship W2114667085A5075382072 @default.
- W2114667085 hasAuthorship W2114667085A5089703861 @default.
- W2114667085 hasBestOaLocation W21146670851 @default.
- W2114667085 hasConcept C126322002 @default.
- W2114667085 hasConcept C185592680 @default.
- W2114667085 hasConcept C2776637226 @default.
- W2114667085 hasConcept C2778722691 @default.
- W2114667085 hasConcept C2779170986 @default.
- W2114667085 hasConcept C2994427840 @default.
- W2114667085 hasConcept C41260117 @default.
- W2114667085 hasConcept C55493867 @default.
- W2114667085 hasConcept C71924100 @default.
- W2114667085 hasConcept C98274493 @default.
- W2114667085 hasConceptScore W2114667085C126322002 @default.
- W2114667085 hasConceptScore W2114667085C185592680 @default.
- W2114667085 hasConceptScore W2114667085C2776637226 @default.
- W2114667085 hasConceptScore W2114667085C2778722691 @default.
- W2114667085 hasConceptScore W2114667085C2779170986 @default.
- W2114667085 hasConceptScore W2114667085C2994427840 @default.
- W2114667085 hasConceptScore W2114667085C41260117 @default.
- W2114667085 hasConceptScore W2114667085C55493867 @default.
- W2114667085 hasConceptScore W2114667085C71924100 @default.
- W2114667085 hasConceptScore W2114667085C98274493 @default.
- W2114667085 hasLocation W21146670851 @default.
- W2114667085 hasLocation W21146670852 @default.