Matches in SemOpenAlex for { <https://semopenalex.org/work/W2115367257> ?p ?o ?g. }
- W2115367257 endingPage "484" @default.
- W2115367257 startingPage "475" @default.
- W2115367257 abstract "Toll-like receptor (TLR) 4 is essential for the defense against infection with gram-negative pathogens, but reduced TLR4 expression has not been linked to altered disease susceptibility in humans. In mice, Tlr4 controls the mucosal response to Escherichia coli urinary tract infections. Inactivation of mouse Tlr4 causes an asymptomatic carrier state resembling asymptomatic bacteriuria (ABU). The present study compared neutrophil TLR4 expression levels between children with ABU (n=17) and age-matched control subjects (n=24), and significantly lower levels were detected in the patients with ABU. We also found elevated levels of the TLR4 adaptor protein TRIF and reduced levels of the TLR4-inhibitor SIGIRR in the patients with ABU, but MyD88 and TRAM levels were not significantly altered. Altered TLR4 and adaptor protein expression might impair TLR4 signaling and explain the weak mucosal response to urinary tract infection in patients who develop ABU rather than symptomatic disease." @default.
- W2115367257 created "2016-06-24" @default.
- W2115367257 creator A5014748561 @default.
- W2115367257 creator A5060555081 @default.
- W2115367257 creator A5060659614 @default.
- W2115367257 creator A5075750865 @default.
- W2115367257 creator A5077822527 @default.
- W2115367257 creator A5079696999 @default.
- W2115367257 date "2007-08-01" @default.
- W2115367257 modified "2023-09-27" @default.
- W2115367257 title "Reduced Toll‐Like Receptor 4 Expression in Children with Asymptomatic Bacteriuria" @default.
- W2115367257 cites W1483162601 @default.
- W2115367257 cites W1494750937 @default.
- W2115367257 cites W1517293159 @default.
- W2115367257 cites W1520365933 @default.
- W2115367257 cites W1959547582 @default.
- W2115367257 cites W1970555242 @default.
- W2115367257 cites W1971307410 @default.
- W2115367257 cites W1976320059 @default.
- W2115367257 cites W1982637996 @default.
- W2115367257 cites W1989656760 @default.
- W2115367257 cites W2035655971 @default.
- W2115367257 cites W2043765645 @default.
- W2115367257 cites W2066420604 @default.
- W2115367257 cites W2071787226 @default.
- W2115367257 cites W2082890018 @default.
- W2115367257 cites W2082909118 @default.
- W2115367257 cites W2087058049 @default.
- W2115367257 cites W2096070259 @default.
- W2115367257 cites W2101918434 @default.
- W2115367257 cites W2120608316 @default.
- W2115367257 cites W2126142607 @default.
- W2115367257 cites W2127797703 @default.
- W2115367257 cites W2129319296 @default.
- W2115367257 cites W2133700480 @default.
- W2115367257 cites W2134632062 @default.
- W2115367257 cites W2136082432 @default.
- W2115367257 cites W2143582893 @default.
- W2115367257 cites W2147594065 @default.
- W2115367257 cites W2148387062 @default.
- W2115367257 cites W2154280240 @default.
- W2115367257 cites W2157310133 @default.
- W2115367257 cites W2164075646 @default.
- W2115367257 doi "https://doi.org/10.1086/518893" @default.
- W2115367257 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17597463" @default.
- W2115367257 hasPublicationYear "2007" @default.
- W2115367257 type Work @default.
- W2115367257 sameAs 2115367257 @default.
- W2115367257 citedByCount "116" @default.
- W2115367257 countsByYear W21153672572012 @default.
- W2115367257 countsByYear W21153672572013 @default.
- W2115367257 countsByYear W21153672572014 @default.
- W2115367257 countsByYear W21153672572015 @default.
- W2115367257 countsByYear W21153672572016 @default.
- W2115367257 countsByYear W21153672572017 @default.
- W2115367257 countsByYear W21153672572018 @default.
- W2115367257 countsByYear W21153672572019 @default.
- W2115367257 countsByYear W21153672572020 @default.
- W2115367257 countsByYear W21153672572021 @default.
- W2115367257 countsByYear W21153672572022 @default.
- W2115367257 countsByYear W21153672572023 @default.
- W2115367257 crossrefType "journal-article" @default.
- W2115367257 hasAuthorship W2115367257A5014748561 @default.
- W2115367257 hasAuthorship W2115367257A5060555081 @default.
- W2115367257 hasAuthorship W2115367257A5060659614 @default.
- W2115367257 hasAuthorship W2115367257A5075750865 @default.
- W2115367257 hasAuthorship W2115367257A5077822527 @default.
- W2115367257 hasAuthorship W2115367257A5079696999 @default.
- W2115367257 hasBestOaLocation W21153672571 @default.
- W2115367257 hasConcept C126322002 @default.
- W2115367257 hasConcept C136449434 @default.
- W2115367257 hasConcept C170493617 @default.
- W2115367257 hasConcept C203014093 @default.
- W2115367257 hasConcept C2776070231 @default.
- W2115367257 hasConcept C2776216170 @default.
- W2115367257 hasConcept C2776709828 @default.
- W2115367257 hasConcept C2777910003 @default.
- W2115367257 hasConcept C2911155155 @default.
- W2115367257 hasConcept C71924100 @default.
- W2115367257 hasConcept C77411442 @default.
- W2115367257 hasConcept C86803240 @default.
- W2115367257 hasConcept C8891405 @default.
- W2115367257 hasConcept C89423630 @default.
- W2115367257 hasConceptScore W2115367257C126322002 @default.
- W2115367257 hasConceptScore W2115367257C136449434 @default.
- W2115367257 hasConceptScore W2115367257C170493617 @default.
- W2115367257 hasConceptScore W2115367257C203014093 @default.
- W2115367257 hasConceptScore W2115367257C2776070231 @default.
- W2115367257 hasConceptScore W2115367257C2776216170 @default.
- W2115367257 hasConceptScore W2115367257C2776709828 @default.
- W2115367257 hasConceptScore W2115367257C2777910003 @default.
- W2115367257 hasConceptScore W2115367257C2911155155 @default.
- W2115367257 hasConceptScore W2115367257C71924100 @default.
- W2115367257 hasConceptScore W2115367257C77411442 @default.
- W2115367257 hasConceptScore W2115367257C86803240 @default.
- W2115367257 hasConceptScore W2115367257C8891405 @default.
- W2115367257 hasConceptScore W2115367257C89423630 @default.
- W2115367257 hasIssue "3" @default.